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Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity.
World J Gastroenterol. 2015 Sep 21; 21(35):10192-9.WJ

Abstract

AIM

To assess the relationship between non-alcoholic fatty liver disease (NAFLD) with metabolic risk factors and brachial ankle pulse wave velocity (baPWV).

METHODS

A total of 8603 subjects (6662 males and 1941 females) were enrolled during an annual health check-up. Fatty liver was examined using a Philips HD 11 XE multi-function color Doppler diagnostic instrument, and baPWV was determined using a novel arteriosclerosis detection device. Blood pressure (BP), fasting plasma glucose (FPG), waist circumference (WC), plasma triglycerides (TG), high-density lipoprotein (HDL), total cholesterol (TC), low-density lipoprotein (LDL) and uric acid (UA) were measured using standard methods. The relationship between fatty liver with metabolic risk factors and baPWV was analyzed using regression analysis and the χ (2) test.

RESULTS

The values and abnormal rates of baPWV were significantly different between NAFLD patients and non-NAFLD subjects (P < 0.001). In addition, the values of baPWV were different by gender between NAFLD patients and non-NAFLD subjects. The OR values in females, males, and the entire population were 3.33, 1.67, and 2.13, respectively (P < 0.001). The incidence of high baPWV increased with increasing degree of NAFLD (levels 0, 1, 2, and 3) (P < 0.001), which was 45.9%, 54.5%, 60.2%, and 71.4% in males and 27.0%, 49.1%, 55.60%, and 60.0% in females (P < 0.001), respectively. Logistic regression analysis showed that the OR value for baPWV in the non-metabolic syndrome group and the metabolic syndrome group was 1.28 vs 1.14 (males) and 2.55 vs 0.98 (females). The OR values for baPWV in the non-high-BP and high-BP, non-high-WC and high-WC, non-high-FPG and high-FPG, non-high-TG and high-TG, non-high-HDL and high-HDL, non-high-TC and high-TC, non-high-LDL and high-LDL, non-high-UA and high-UA groups were 3.38 vs 1.19, 3.50 vs 1.44, 2.80 vs 2.30, 3.29 vs 1.88, 3.03 vs 3.28, 3.35 vs 2.70, 3.93 vs 1.66, and 3.20 vs 2.34, respectively, in females (P < 0.001), and were 1.37 vs 1.34, 1.56 vs 1.26, 1.51 vs 1.28, 1.49 vs 1.52, 1.71 vs 1.61, 1.59 vs 1.74, 1.76 vs 1.47, and 1.73 vs 1.54, respectively, in males (P < 0.01). The OR value for baPWV was still higher than 1.2 (1.21 in males and 1.40 in females) after adjustment for the metabolic component (0, 1, 2, 3, 4, 5, 6 and above) (P < 0.01).

CONCLUSION

NAFLD is closely correlated with baPWV, particularly in females. NAFLD has a large impact on baPWV, no matter whether the metabolic index is increased or not. NAFLD may be a useful indicator for assessing early arteriosclerosis.

Authors+Show Affiliations

Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.Wen-Hua Zhu, Li-Zheng Fang, Chong-Rong Lu, Hong-Lei Dai, Jian-Hua Chen, Qiao-Hua Qiao, Li-Ying Chen, Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26401084

Citation

Zhu, Wen-Hua, et al. "Correlation Between Non-alcoholic Fatty Liver With Metabolic Risk Factors and Brachial-ankle Pulse Wave Velocity." World Journal of Gastroenterology, vol. 21, no. 35, 2015, pp. 10192-9.
Zhu WH, Fang LZ, Lu CR, et al. Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity. World J Gastroenterol. 2015;21(35):10192-9.
Zhu, W. H., Fang, L. Z., Lu, C. R., Dai, H. L., Chen, J. H., Qiao, Q. H., & Chen, L. Y. (2015). Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity. World Journal of Gastroenterology, 21(35), 10192-9. https://doi.org/10.3748/wjg.v21.i35.10192
Zhu WH, et al. Correlation Between Non-alcoholic Fatty Liver With Metabolic Risk Factors and Brachial-ankle Pulse Wave Velocity. World J Gastroenterol. 2015 Sep 21;21(35):10192-9. PubMed PMID: 26401084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between non-alcoholic fatty liver with metabolic risk factors and brachial-ankle pulse wave velocity. AU - Zhu,Wen-Hua, AU - Fang,Li-Zheng, AU - Lu,Chong-Rong, AU - Dai,Hong-Lei, AU - Chen,Jian-Hua, AU - Qiao,Qiao-Hua, AU - Chen,Li-Ying, PY - 2015/03/01/received PY - 2015/05/18/revised PY - 2015/07/15/accepted PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/10/12/medline KW - Brachial ankle pulse wave velocity KW - Metabolic risk factors KW - Non-alcoholic fatty liver SP - 10192 EP - 9 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 21 IS - 35 N2 - AIM: To assess the relationship between non-alcoholic fatty liver disease (NAFLD) with metabolic risk factors and brachial ankle pulse wave velocity (baPWV). METHODS: A total of 8603 subjects (6662 males and 1941 females) were enrolled during an annual health check-up. Fatty liver was examined using a Philips HD 11 XE multi-function color Doppler diagnostic instrument, and baPWV was determined using a novel arteriosclerosis detection device. Blood pressure (BP), fasting plasma glucose (FPG), waist circumference (WC), plasma triglycerides (TG), high-density lipoprotein (HDL), total cholesterol (TC), low-density lipoprotein (LDL) and uric acid (UA) were measured using standard methods. The relationship between fatty liver with metabolic risk factors and baPWV was analyzed using regression analysis and the χ (2) test. RESULTS: The values and abnormal rates of baPWV were significantly different between NAFLD patients and non-NAFLD subjects (P < 0.001). In addition, the values of baPWV were different by gender between NAFLD patients and non-NAFLD subjects. The OR values in females, males, and the entire population were 3.33, 1.67, and 2.13, respectively (P < 0.001). The incidence of high baPWV increased with increasing degree of NAFLD (levels 0, 1, 2, and 3) (P < 0.001), which was 45.9%, 54.5%, 60.2%, and 71.4% in males and 27.0%, 49.1%, 55.60%, and 60.0% in females (P < 0.001), respectively. Logistic regression analysis showed that the OR value for baPWV in the non-metabolic syndrome group and the metabolic syndrome group was 1.28 vs 1.14 (males) and 2.55 vs 0.98 (females). The OR values for baPWV in the non-high-BP and high-BP, non-high-WC and high-WC, non-high-FPG and high-FPG, non-high-TG and high-TG, non-high-HDL and high-HDL, non-high-TC and high-TC, non-high-LDL and high-LDL, non-high-UA and high-UA groups were 3.38 vs 1.19, 3.50 vs 1.44, 2.80 vs 2.30, 3.29 vs 1.88, 3.03 vs 3.28, 3.35 vs 2.70, 3.93 vs 1.66, and 3.20 vs 2.34, respectively, in females (P < 0.001), and were 1.37 vs 1.34, 1.56 vs 1.26, 1.51 vs 1.28, 1.49 vs 1.52, 1.71 vs 1.61, 1.59 vs 1.74, 1.76 vs 1.47, and 1.73 vs 1.54, respectively, in males (P < 0.01). The OR value for baPWV was still higher than 1.2 (1.21 in males and 1.40 in females) after adjustment for the metabolic component (0, 1, 2, 3, 4, 5, 6 and above) (P < 0.01). CONCLUSION: NAFLD is closely correlated with baPWV, particularly in females. NAFLD has a large impact on baPWV, no matter whether the metabolic index is increased or not. NAFLD may be a useful indicator for assessing early arteriosclerosis. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26401084/Correlation_between_non_alcoholic_fatty_liver_with_metabolic_risk_factors_and_brachial_ankle_pulse_wave_velocity_ L2 - https://www.wjgnet.com/1007-9327/full/v21/i35/10192.htm DB - PRIME DP - Unbound Medicine ER -