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Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products.
Int J Food Sci Nutr. 2015; 66(7):766-73.IJ

Abstract

Extra virgin olive oil (EVOO) major and minor component anti-inflammatory effect on aorta was evaluated; Wistar rats were fed (9 weeks) on either a high-cholesterol diet (HCD) or a HCD supplemented with oils, i.e. EVOO, sunflower oil (SO), high-oleic sunflower oil (HOSO), or oil-products modified to their phenolic content, i.e. phenolics deprived-EVOO [EVOO(-)], SO enriched with the EVOO phenolics [SO(+)], HOSO enriched with the EVOO phenolics [HOSO(+)]. HCD induced dyslipidemia and resulted in higher aorta adhesion molecules levels at euthanasia. Groups receiving EVOO, EVOO(-), HOSO, HOSO(+) presented higher serum TC and LDL-c levels compared to cholesterol-fed rats; attenuation of aorta E-selectin levels was also observed. In EVOO/EVOO(-) groups, aorta vascular endothelial adhesion molecule-1 (VCAM-1) was lower compared to HCD animals. SO/SO(+) diets had no effect on endothelial dysfunction amelioration. Overall, our results suggest that major and/or minor EVOO constituents improve aorta E-selectin and VCAM-1, while serum lipids do not benefit.

Authors+Show Affiliations

a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .b Experimental-Research Center ELPEN , Pikermi , Athens , Greece , and.a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .c Laboratory of Pathology , School of Medicine, University of Athens , Athens , Greece.a Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics , School of Health Science and Education, Harokopio University , Kallithea , Athens , Greece .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26401576

Citation

Katsarou, Ageliki I., et al. "Serum Lipid Profile and Inflammatory Markers in the Aorta of Cholesterol-fed Rats Supplemented With Extra Virgin Olive Oil, Sunflower Oils and Oil-products." International Journal of Food Sciences and Nutrition, vol. 66, no. 7, 2015, pp. 766-73.
Katsarou AI, Kaliora AC, Papalois A, et al. Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products. Int J Food Sci Nutr. 2015;66(7):766-73.
Katsarou, A. I., Kaliora, A. C., Papalois, A., Chiou, A., Kalogeropoulos, N., Agrogiannis, G., & Andrikopoulos, N. K. (2015). Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products. International Journal of Food Sciences and Nutrition, 66(7), 766-73. https://doi.org/10.3109/09637486.2015.1088936
Katsarou AI, et al. Serum Lipid Profile and Inflammatory Markers in the Aorta of Cholesterol-fed Rats Supplemented With Extra Virgin Olive Oil, Sunflower Oils and Oil-products. Int J Food Sci Nutr. 2015;66(7):766-73. PubMed PMID: 26401576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products. AU - Katsarou,Ageliki I, AU - Kaliora,Andriana C, AU - Papalois,Apostolos, AU - Chiou,Antonia, AU - Kalogeropoulos,Nick, AU - Agrogiannis,George, AU - Andrikopoulos,Nikolaos K, Y1 - 2015/09/24/ PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/8/2/medline KW - E-selectin KW - VCAM-1 KW - olive oil KW - polar phenolic compounds KW - serum lipid profile KW - sunflower oil SP - 766 EP - 73 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 66 IS - 7 N2 - Extra virgin olive oil (EVOO) major and minor component anti-inflammatory effect on aorta was evaluated; Wistar rats were fed (9 weeks) on either a high-cholesterol diet (HCD) or a HCD supplemented with oils, i.e. EVOO, sunflower oil (SO), high-oleic sunflower oil (HOSO), or oil-products modified to their phenolic content, i.e. phenolics deprived-EVOO [EVOO(-)], SO enriched with the EVOO phenolics [SO(+)], HOSO enriched with the EVOO phenolics [HOSO(+)]. HCD induced dyslipidemia and resulted in higher aorta adhesion molecules levels at euthanasia. Groups receiving EVOO, EVOO(-), HOSO, HOSO(+) presented higher serum TC and LDL-c levels compared to cholesterol-fed rats; attenuation of aorta E-selectin levels was also observed. In EVOO/EVOO(-) groups, aorta vascular endothelial adhesion molecule-1 (VCAM-1) was lower compared to HCD animals. SO/SO(+) diets had no effect on endothelial dysfunction amelioration. Overall, our results suggest that major and/or minor EVOO constituents improve aorta E-selectin and VCAM-1, while serum lipids do not benefit. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/26401576/Serum_lipid_profile_and_inflammatory_markers_in_the_aorta_of_cholesterol_fed_rats_supplemented_with_extra_virgin_olive_oil_sunflower_oils_and_oil_products_ L2 - https://www.tandfonline.com/doi/full/10.3109/09637486.2015.1088936 DB - PRIME DP - Unbound Medicine ER -