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Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging.
J Alzheimers Dis. 2015; 47(4):889-99.JA

Abstract

Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia. We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to ±1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (<1 cup of coffee/day) (HR: 2.17, 95% CI: 1.16 to 4.08). Finally, there was no significant association between subjects with higher levels of coffee consumption (>2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI.

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Authors+Show Affiliations

Solfrizzi V
Geriatric Medicine-Memory Unit, Rare Disease Centre, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Panza F
Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy. Department of Clinical Research in Neurology, University of Bari Aldo Moro, "Pia Fondazione Cardinale G. Panico", Tricase, Lecce, Italy. Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Imbimbo BP
Department of Research and Development, Chiesi Farmaceutici, Parma, Italy.
D'Introno A
Geriatric Medicine-Memory Unit, Rare Disease Centre, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Galluzzo L
Population Health and Health Determinants Unit, National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS), Istituto Superiore di Sanità (ISS), Roma, Italy.
Gandin C
Population Health and Health Determinants Unit, National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS), Istituto Superiore di Sanità (ISS), Roma, Italy.
Misciagna G
Laboratory of Epidemiology and Biostatistics, National Institute for Digestive Diseases, IRCCS "Saverio de Bellis", Castellana, Bari, Italy.
Guerra V
Trials Centre, National Institute for Digestive Diseases, IRCCS "Saverio de Bellis", Castellana, Bari, Italy.
Osella A
Laboratory of Epidemiology and Biostatistics, National Institute for Digestive Diseases, IRCCS "Saverio de Bellis", Castellana, Bari, Italy.
Baldereschi M
Institute of Neuroscience, Italian National Research Council (CNR), Firenze, Italy.
Di Carlo A
Institute of Neuroscience, Italian National Research Council (CNR), Firenze, Italy.
Inzitari D
Department of Neurological and Psychiatric Sciences, University of Firenze, Firenze, Italy.
Seripa D
Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Pilotto A
Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy. Geriatrics Unit, Department of OrthoGeriatrics, Rehabilitation and Stabilization, Frailty Area, Galliera Hospital NR-HS, Genova, Italy.
Sabbá C
Geriatric Medicine-Memory Unit, Rare Disease Centre, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Logroscino G
Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy. Department of Clinical Research in Neurology, University of Bari Aldo Moro, "Pia Fondazione Cardinale G. Panico", Tricase, Lecce, Italy.
Scafato E
Population Health and Health Determinants Unit, National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS), Istituto Superiore di Sanità (ISS), Roma, Italy.
Italian Longitudinal Study on Aging Working Group
No affiliation info available

MeSH

AgedAged, 80 and overAgingCaffeineCoffeeCognitive DysfunctionDepressionFeeding BehaviorFollow-Up StudiesHumansItalyLongitudinal StudiesMenNeuropsychological TestsRiskSex FactorsTeaWomen

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26401769

Citation

Solfrizzi, Vincenzo, et al. "Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: the Italian Longitudinal Study On Aging." Journal of Alzheimer's Disease : JAD, vol. 47, no. 4, 2015, pp. 889-99.
Solfrizzi V, Panza F, Imbimbo BP, et al. Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging. J Alzheimers Dis. 2015;47(4):889-99.
Solfrizzi, V., Panza, F., Imbimbo, B. P., D'Introno, A., Galluzzo, L., Gandin, C., Misciagna, G., Guerra, V., Osella, A., Baldereschi, M., Di Carlo, A., Inzitari, D., Seripa, D., Pilotto, A., Sabbá, C., Logroscino, G., & Scafato, E. (2015). Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging. Journal of Alzheimer's Disease : JAD, 47(4), 889-99. https://doi.org/10.3233/JAD-150333
Solfrizzi V, et al. Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: the Italian Longitudinal Study On Aging. J Alzheimers Dis. 2015;47(4):889-99. PubMed PMID: 26401769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging. AU - Solfrizzi,Vincenzo, AU - Panza,Francesco, AU - Imbimbo,Bruno P, AU - D'Introno,Alessia, AU - Galluzzo,Lucia, AU - Gandin,Claudia, AU - Misciagna,Giovanni, AU - Guerra,Vito, AU - Osella,Alberto, AU - Baldereschi,Marzia, AU - Di Carlo,Antonio, AU - Inzitari,Domenico, AU - Seripa,Davide, AU - Pilotto,Alberto, AU - Sabbá,Carlo, AU - Logroscino,Giancarlo, AU - Scafato,Emanuele, AU - ,, PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/7/7/medline KW - Alzheimer’s disease KW - caffeine use KW - coffee consumption KW - dementia KW - mild cognitive impairment SP - 889 EP - 99 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 47 IS - 4 N2 - Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia. We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to ±1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (<1 cup of coffee/day) (HR: 2.17, 95% CI: 1.16 to 4.08). Finally, there was no significant association between subjects with higher levels of coffee consumption (>2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/26401769/Coffee_Consumption_Habits_and_the_Risk_of_Mild_Cognitive_Impairment:_The_Italian_Longitudinal_Study_on_Aging_ DB - PRIME DP - Unbound Medicine ER -