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37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden.

Abstract

BACKGROUND

Overweight and obesity in mid- and late-life may increase risk for dementia, whereas a decline in body weight or body mass index (BMI) and underweight in years preceding a clinical dementia diagnosis are also associated with dementia. Little is known about the modifying effect of the APOE genotype, a major susceptibility gene for Alzheimer's disease (AD), on the BMI-dementia adult life course trajectory.

OBJECTIVE

We evaluated the exposure, BMI, in relationship to the outcome, clinical dementia, over 37 years, considering the effect modification of the APOE ɛ4 allele.

METHODS

The Prospective Population Study of Women (PPSW) in Sweden is a systematic sample of 1462 women born 1908, 1914, 1918, 1922, and 1930 and aged 38-60 years at baseline. Examinations occurred in 1968, 1974, 1980, 1992, 2000, and 2005; 559 women had information on dementia, BMI, and APOE ɛ4 allele status, in addition to covariates. Statistical analyses were conducted using mixed effects regression models.

RESULTS

Trajectories of BMI over 37 years differed by APOE ɛ4 allele status. While women gained BMI similarly from mid-life to age 70 years, women with at least one APOE ɛ4 allele experienced BMI decline more quickly after age 70 years compared to women without an APOE ɛ4 allele. However, upon stratifying the sample by dementia occurrence, it appeared that dementia drove the overall BMI-trajectory. There was a main effect of age, interactions of age by APOE ɛ4 allele status, and age by presence versus absence of dementia.

CONCLUSIONS

Women with similar average BMI at mid-life exhibited different BMI trajectories in relation to dementia occurrence. In addition, the pattern of BMI decline in late-life differed on the basis of APOE ɛ4 allele possession. Thus, these data suggest roles for both dementia- and APOE-associated changes in BMI during the adult life course.

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  • Authors+Show Affiliations

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    ,

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Neurology, State University of New York-Downstate Medical Center, Brooklyn, NY, USA.

    Source

    MeSH

    Adult
    Age Factors
    Aged
    Alleles
    Apolipoprotein E4
    Body Mass Index
    Body Weight
    Dementia
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Prospective Studies
    Risk Factors
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26402098

    Citation

    Bäckman, Kristoffer, et al. "37 Years of Body Mass Index and Dementia: Effect Modification By the APOE Genotype: Observations From the Prospective Population Study of Women in Gothenburg, Sweden." Journal of Alzheimer's Disease : JAD, vol. 48, no. 4, 2015, pp. 1119-27.
    Bäckman K, Joas E, Waern M, et al. 37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden. J Alzheimers Dis. 2015;48(4):1119-27.
    Bäckman, K., Joas, E., Waern, M., Östling, S., Guo, X., Blennow, K., ... Gustafson, D. R. (2015). 37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden. Journal of Alzheimer's Disease : JAD, 48(4), pp. 1119-27. doi:10.3233/JAD-150326.
    Bäckman K, et al. 37 Years of Body Mass Index and Dementia: Effect Modification By the APOE Genotype: Observations From the Prospective Population Study of Women in Gothenburg, Sweden. J Alzheimers Dis. 2015;48(4):1119-27. PubMed PMID: 26402098.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - 37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden. AU - Bäckman,Kristoffer, AU - Joas,Erik, AU - Waern,Margda, AU - Östling,Svante, AU - Guo,Xinxin, AU - Blennow,Kaj, AU - Skoog,Ingmar, AU - Gustafson,Deborah R, PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/8/4/medline KW - APOE KW - Alzheimer’s disease KW - body mass index change KW - dementia KW - prospective KW - risk factor SP - 1119 EP - 27 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 48 IS - 4 N2 - BACKGROUND: Overweight and obesity in mid- and late-life may increase risk for dementia, whereas a decline in body weight or body mass index (BMI) and underweight in years preceding a clinical dementia diagnosis are also associated with dementia. Little is known about the modifying effect of the APOE genotype, a major susceptibility gene for Alzheimer's disease (AD), on the BMI-dementia adult life course trajectory. OBJECTIVE: We evaluated the exposure, BMI, in relationship to the outcome, clinical dementia, over 37 years, considering the effect modification of the APOE ɛ4 allele. METHODS: The Prospective Population Study of Women (PPSW) in Sweden is a systematic sample of 1462 women born 1908, 1914, 1918, 1922, and 1930 and aged 38-60 years at baseline. Examinations occurred in 1968, 1974, 1980, 1992, 2000, and 2005; 559 women had information on dementia, BMI, and APOE ɛ4 allele status, in addition to covariates. Statistical analyses were conducted using mixed effects regression models. RESULTS: Trajectories of BMI over 37 years differed by APOE ɛ4 allele status. While women gained BMI similarly from mid-life to age 70 years, women with at least one APOE ɛ4 allele experienced BMI decline more quickly after age 70 years compared to women without an APOE ɛ4 allele. However, upon stratifying the sample by dementia occurrence, it appeared that dementia drove the overall BMI-trajectory. There was a main effect of age, interactions of age by APOE ɛ4 allele status, and age by presence versus absence of dementia. CONCLUSIONS: Women with similar average BMI at mid-life exhibited different BMI trajectories in relation to dementia occurrence. In addition, the pattern of BMI decline in late-life differed on the basis of APOE ɛ4 allele possession. Thus, these data suggest roles for both dementia- and APOE-associated changes in BMI during the adult life course. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/26402098/37_Years_of_Body_Mass_Index_and_Dementia:_Effect_Modification_by_the_APOE_Genotype:_Observations_from_the_Prospective_Population_Study_of_Women_in_Gothenburg_Sweden_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-150326 DB - PRIME DP - Unbound Medicine ER -