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miRNAs: Key Players in Neurodegenerative Disorders and Epilepsy.
J Alzheimers Dis. 2015; 48(3):563-80.JA

Abstract

MicroRNAs (miRNAs) are endogenous, ∼22 nucleotide, non-coding RNA molecules that function as post-transcriptional regulators of gene expression. miRNA dysregulation has been observed in cancer and in neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and the neurological disorder, epilepsy. Neuronal degradation and death are important hallmarks of neurodegenerative disorders. Additionally, abnormalities in metabolism, synapsis and axonal transport have been associated with Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. A number of recently published studies have demonstrated the importance of miRNAs in the nervous system and have contributed to the growing body of evidence on miRNA dysregulation in neurological disorders. Knowledge of the expressions and activities of such miRNAs may aid in the development of novel therapeutics. In this review, we discuss the significance of miRNA dysregulation in the development of neurodegenerative disorders and the use of miRNAs as targets for therapeutic intervention.

Authors+Show Affiliations

Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, Telangana, India.Department of Neurosurgery, Krishna Institute of Medical Sciences (KIMS), Hyderabad, Telangana, India.Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, Telangana, India.Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26402105

Citation

Karnati, Hanuma Kumar, et al. "MiRNAs: Key Players in Neurodegenerative Disorders and Epilepsy." Journal of Alzheimer's Disease : JAD, vol. 48, no. 3, 2015, pp. 563-80.
Karnati HK, Panigrahi MK, Gutti RK, et al. MiRNAs: Key Players in Neurodegenerative Disorders and Epilepsy. J Alzheimers Dis. 2015;48(3):563-80.
Karnati, H. K., Panigrahi, M. K., Gutti, R. K., Greig, N. H., & Tamargo, I. A. (2015). MiRNAs: Key Players in Neurodegenerative Disorders and Epilepsy. Journal of Alzheimer's Disease : JAD, 48(3), 563-80. https://doi.org/10.3233/JAD-150395
Karnati HK, et al. MiRNAs: Key Players in Neurodegenerative Disorders and Epilepsy. J Alzheimers Dis. 2015;48(3):563-80. PubMed PMID: 26402105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - miRNAs: Key Players in Neurodegenerative Disorders and Epilepsy. AU - Karnati,Hanuma Kumar, AU - Panigrahi,Manas Kumar, AU - Gutti,Ravi Kumar, AU - Greig,Nigel H, AU - Tamargo,Ian A, PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/7/15/medline KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - amyotrophic lateral sclerosis KW - epilepsy KW - miRNAs KW - neurodegenerative disorders SP - 563 EP - 80 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 48 IS - 3 N2 - MicroRNAs (miRNAs) are endogenous, ∼22 nucleotide, non-coding RNA molecules that function as post-transcriptional regulators of gene expression. miRNA dysregulation has been observed in cancer and in neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and the neurological disorder, epilepsy. Neuronal degradation and death are important hallmarks of neurodegenerative disorders. Additionally, abnormalities in metabolism, synapsis and axonal transport have been associated with Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. A number of recently published studies have demonstrated the importance of miRNAs in the nervous system and have contributed to the growing body of evidence on miRNA dysregulation in neurological disorders. Knowledge of the expressions and activities of such miRNAs may aid in the development of novel therapeutics. In this review, we discuss the significance of miRNA dysregulation in the development of neurodegenerative disorders and the use of miRNAs as targets for therapeutic intervention. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/26402105/miRNAs:_Key_Players_in_Neurodegenerative_Disorders_and_Epilepsy_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-150395 DB - PRIME DP - Unbound Medicine ER -