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A prospective study of coffee intake and pancreatic cancer: results from the NIH-AARP Diet and Health Study.
Br J Cancer 2015; 113(7):1081-5BJ

Abstract

BACKGROUND

Evidence evaluating the association between type of coffee intake (caffeinated, decaffeinated) and risk of pancreatic cancer is limited.

METHODS

In the US NIH-AARP Diet and Health Study, we used Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals (CIs) for coffee intake and risk of pancreatic cancer among 457 366 US adults.

RESULTS

Over 4 155 256 person-years of follow-up, 1541 incident first primary pancreatic cancers occurred. Following detailed adjustment for tobacco smoking history, risk estimates for coffee drinking were not statistically significant; compared with never drinkers of coffee, the hazard ratios (95% CI) were 1.05 (0.85-1.30), 1.06 (0.86-1.31), 1.03 (0.85-1.25), 1.00 (0.79-1.25), and 1.24 (0.93-1.65) for <1, 1, 2-3, 4-5, and ≥6 cups per day, respectively (P-value for trend 0.46). The observed null association was consistent across all examined strata (sex, smoking status, coffee caffeination, and prevalent diabetes).

CONCLUSIONS

In a prospective study of coffee intake with the largest number of pancreatic cancer cases to date, we did not observe an association between total, caffeinated, or decaffeinated coffee intake and pancreatic cancer.

Authors+Show Affiliations

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, 9609 Medical Center Drive, Room 6E326, MSC 9760, Bethesda, MD 20892, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

26402414

Citation

Guertin, K A., et al. "A Prospective Study of Coffee Intake and Pancreatic Cancer: Results From the NIH-AARP Diet and Health Study." British Journal of Cancer, vol. 113, no. 7, 2015, pp. 1081-5.
Guertin KA, Freedman ND, Loftfield E, et al. A prospective study of coffee intake and pancreatic cancer: results from the NIH-AARP Diet and Health Study. Br J Cancer. 2015;113(7):1081-5.
Guertin, K. A., Freedman, N. D., Loftfield, E., Stolzenberg-Solomon, R. Z., Graubard, B. I., & Sinha, R. (2015). A prospective study of coffee intake and pancreatic cancer: results from the NIH-AARP Diet and Health Study. British Journal of Cancer, 113(7), pp. 1081-5. doi:10.1038/bjc.2015.235.
Guertin KA, et al. A Prospective Study of Coffee Intake and Pancreatic Cancer: Results From the NIH-AARP Diet and Health Study. Br J Cancer. 2015 Sep 29;113(7):1081-5. PubMed PMID: 26402414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of coffee intake and pancreatic cancer: results from the NIH-AARP Diet and Health Study. AU - Guertin,K A, AU - Freedman,N D, AU - Loftfield,E, AU - Stolzenberg-Solomon,R Z, AU - Graubard,B I, AU - Sinha,R, Y1 - 2015/09/24/ PY - 2015/03/06/received PY - 2015/05/20/revised PY - 2015/06/01/accepted PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/1/5/medline SP - 1081 EP - 5 JF - British journal of cancer JO - Br. J. Cancer VL - 113 IS - 7 N2 - BACKGROUND: Evidence evaluating the association between type of coffee intake (caffeinated, decaffeinated) and risk of pancreatic cancer is limited. METHODS: In the US NIH-AARP Diet and Health Study, we used Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals (CIs) for coffee intake and risk of pancreatic cancer among 457 366 US adults. RESULTS: Over 4 155 256 person-years of follow-up, 1541 incident first primary pancreatic cancers occurred. Following detailed adjustment for tobacco smoking history, risk estimates for coffee drinking were not statistically significant; compared with never drinkers of coffee, the hazard ratios (95% CI) were 1.05 (0.85-1.30), 1.06 (0.86-1.31), 1.03 (0.85-1.25), 1.00 (0.79-1.25), and 1.24 (0.93-1.65) for <1, 1, 2-3, 4-5, and ≥6 cups per day, respectively (P-value for trend 0.46). The observed null association was consistent across all examined strata (sex, smoking status, coffee caffeination, and prevalent diabetes). CONCLUSIONS: In a prospective study of coffee intake with the largest number of pancreatic cancer cases to date, we did not observe an association between total, caffeinated, or decaffeinated coffee intake and pancreatic cancer. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/26402414/A_prospective_study_of_coffee_intake_and_pancreatic_cancer:_results_from_the_NIH_AARP_Diet_and_Health_Study_ L2 - http://dx.doi.org/10.1038/bjc.2015.235 DB - PRIME DP - Unbound Medicine ER -