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Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis.

Abstract

Coeliac disease (CD) is reported to be associated with risk of malignancy; however, this association remains unclear. We aimed to systematically evaluate the association between CD and risk of all malignancies as well as gastrointestinal (GI) malignancy specifically. The PUBMED and EMBASE databases were searched to identify eligible studies from 1960 to March 2015, without restriction. Two reviewers independently performed the study inclusion and data extraction methods. Odds ratios (ORs), risk ratios, or standardized incidence ratios were pooled using either a fixed- or a random-effects model. Sensitivity and subgroup analyses were used to explore sources of heterogeneity. A total of 17 studies were included in this meta-analysis. The pooled OR for risk of all malignancies was 1.25 (95% confidence interval [CI] 1.09-1.44), whereas the pooled OR for risk of GI malignancy was 1.60 (95% CI 1.39-1.84) and suggested an inverse association with CD. Moreover, patients with CD were at a higher risk of esophageal cancer (pooled OR = 3.72, 95% CI 1.90-7.28) and small intestinal carcinoma (pooled OR = 14.41, 95% CI 5.53-37.60), whereas no significant associations were observed for other GI cancers, including gastric, colorectal, liver, and pancreatic cancers. Subgroup analyses also indicated that the results were influenced by the CD diagnostic method, as well as the follow-up time after CD diagnosis. CD was associated with increased risk of all malignancies as well as GI malignancies, including esophageal cancer and small intestinal carcinoma.

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  • Authors+Show Affiliations

    ,

    From the Department of Gastroenterology (YH, WC, PL, JY), The Second Affiliated Hospital, Zhejiang University School of Medicine; and Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital (JY), Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

    , ,

    Source

    Medicine 94:38 2015 Sep pg e1612

    MeSH

    Carcinoma
    Celiac Disease
    Esophageal Neoplasms
    Humans
    Intestinal Neoplasms
    Risk Assessment

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26402826

    Citation

    Han, Yuehua, et al. "Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: a Meta-Analysis." Medicine, vol. 94, no. 38, 2015, pp. e1612.
    Han Y, Chen W, Li P, et al. Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis. Medicine (Baltimore). 2015;94(38):e1612.
    Han, Y., Chen, W., Li, P., & Ye, J. (2015). Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis. Medicine, 94(38), pp. e1612. doi:10.1097/MD.0000000000001612.
    Han Y, et al. Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: a Meta-Analysis. Medicine (Baltimore). 2015;94(38):e1612. PubMed PMID: 26402826.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis. AU - Han,Yuehua, AU - Chen,Wuzhen, AU - Li,Peiwei, AU - Ye,Jun, PY - 2015/9/25/entrez PY - 2015/9/25/pubmed PY - 2016/1/9/medline SP - e1612 EP - e1612 JF - Medicine JO - Medicine (Baltimore) VL - 94 IS - 38 N2 - Coeliac disease (CD) is reported to be associated with risk of malignancy; however, this association remains unclear. We aimed to systematically evaluate the association between CD and risk of all malignancies as well as gastrointestinal (GI) malignancy specifically. The PUBMED and EMBASE databases were searched to identify eligible studies from 1960 to March 2015, without restriction. Two reviewers independently performed the study inclusion and data extraction methods. Odds ratios (ORs), risk ratios, or standardized incidence ratios were pooled using either a fixed- or a random-effects model. Sensitivity and subgroup analyses were used to explore sources of heterogeneity. A total of 17 studies were included in this meta-analysis. The pooled OR for risk of all malignancies was 1.25 (95% confidence interval [CI] 1.09-1.44), whereas the pooled OR for risk of GI malignancy was 1.60 (95% CI 1.39-1.84) and suggested an inverse association with CD. Moreover, patients with CD were at a higher risk of esophageal cancer (pooled OR = 3.72, 95% CI 1.90-7.28) and small intestinal carcinoma (pooled OR = 14.41, 95% CI 5.53-37.60), whereas no significant associations were observed for other GI cancers, including gastric, colorectal, liver, and pancreatic cancers. Subgroup analyses also indicated that the results were influenced by the CD diagnostic method, as well as the follow-up time after CD diagnosis. CD was associated with increased risk of all malignancies as well as GI malignancies, including esophageal cancer and small intestinal carcinoma. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26402826/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=26402826 DB - PRIME DP - Unbound Medicine ER -