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Body mass index at age 18-20 and later risk of spontaneous abortion in the Health Examinees Study (HEXA).

Abstract

BACKGROUND

Spontaneous abortion (SA) affects 11.2% of recognized pregnancies in Korea. Many studies have focused on the increased risk of SA in obese populations, but there are few studies that have focused on underweight (Body mass index (BMI) <18.5 kg/m2) women, especially in relation to pre-pregnancy BMI. The aim of this study was to examine the role of pre-pregnancy BMI at age 18-20 in later SA.

METHODS

Among the women who were ever pregnant in the Health Examinees Study (HEXA), which was one of the cohorts studied in the KoGES (Korean Genome and Epidemiology Study) from 2004 to 2012 (N = 80,447), the likelihood of SA based on pre-pregnancy BMI, classified by the criteria for Asians (Underweight: <18.5 kg/m2; Normal range: 18.5-22.9 kg/m2; Overweight at risk: 23-24.9 kg/m2; Obese I: 25-29.9 kg/m2; Obese II: ≥30 kg/m2), was presented as odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression models.

RESULTS

Being underweight or obese relative to the normal weight range was associated with a higher likelihood of SA (OR = 1.10 [95% CI = 1.05-1.15] in underweight women and OR = 1.06 [95% CI = 0.96-1.16] in obese women), and this effect was much greater in women who experienced recurrent SAs (for three or more SAs: OR = 1.29 [95% CI 1.14-1.46] in underweight women and OR = 1.39 [95% CI 1.09-1.78] in obese women). Obesity was associated with an increased likelihood of SA at a younger age (≤25 years), whereas underweight was associated with an increased OR of SA at an older age (≥26 years).

DISCUSSION

As this study was conducted with baseline data of original cohort which focused on other chronic diseases, recall for previous pregnancy-related information might be less accurate. However, this study shows strength in its large size and prospective potential.

CONCLUSIONS

Pre-pregnancy BMI at ages 18-20 years revealed a U-shaped association with SA, and underweight and obese women showed increased likelihood for SA during different age periods.

Authors+Show Affiliations

Department of Biomedical Science, Seoul National University College of Medicine, Seoul, South Korea. sunjae@snu.ac.kr.Department of Biomedical Science, Seoul National University College of Medicine, Seoul, South Korea. suepark@snu.ac.kr. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. suepark@snu.ac.kr. Cancer Research Institute, Seoul National University Hospital, Seoul, South Korea. suepark@snu.ac.kr.Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. shinaesun@snu.ac.kr.Department of Preventive Medicine, Kangwon National University, Seoul, South Korea. sangahlee@kangwon.ac.kr.Department of Biomedical Science, Seoul National University College of Medicine, Seoul, South Korea. jiyeob.choi@gmail.com.Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. ychong1@snu.ac.kr.Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. kyyoo@snu.ac.kr.Department of Family Medicine, Seoul National University Hospital, Seoul, South Korea. docmohw@snu.ac.kr.Department of Biomedical Science, Seoul National University College of Medicine, Seoul, South Korea. dhkang@snu.ac.kr. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. dhkang@snu.ac.kr. Cancer Research Institute, Seoul National University Hospital, Seoul, South Korea. dhkang@snu.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26403183

Citation

Jung, Sun Jae, et al. "Body Mass Index at Age 18-20 and Later Risk of Spontaneous Abortion in the Health Examinees Study (HEXA)." BMC Pregnancy and Childbirth, vol. 15, 2015, p. 228.
Jung SJ, Park SK, Shin A, et al. Body mass index at age 18-20 and later risk of spontaneous abortion in the Health Examinees Study (HEXA). BMC Pregnancy Childbirth. 2015;15:228.
Jung, S. J., Park, S. K., Shin, A., Lee, S. A., Choi, J. Y., Hong, Y. C., ... Kang, D. (2015). Body mass index at age 18-20 and later risk of spontaneous abortion in the Health Examinees Study (HEXA). BMC Pregnancy and Childbirth, 15, p. 228. doi:10.1186/s12884-015-0665-2.
Jung SJ, et al. Body Mass Index at Age 18-20 and Later Risk of Spontaneous Abortion in the Health Examinees Study (HEXA). BMC Pregnancy Childbirth. 2015 Sep 24;15:228. PubMed PMID: 26403183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index at age 18-20 and later risk of spontaneous abortion in the Health Examinees Study (HEXA). AU - Jung,Sun Jae, AU - Park,Sue Kyung, AU - Shin,Aesun, AU - Lee,Sang-Ah, AU - Choi,Ji-Yeob, AU - Hong,Yun-Chul, AU - Yoo,Keun-Young, AU - Lee,Jong-Koo, AU - Kang,Daehee, Y1 - 2015/09/24/ PY - 2015/02/26/received PY - 2015/09/21/accepted PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/7/7/medline SP - 228 EP - 228 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 15 N2 - BACKGROUND: Spontaneous abortion (SA) affects 11.2% of recognized pregnancies in Korea. Many studies have focused on the increased risk of SA in obese populations, but there are few studies that have focused on underweight (Body mass index (BMI) <18.5 kg/m2) women, especially in relation to pre-pregnancy BMI. The aim of this study was to examine the role of pre-pregnancy BMI at age 18-20 in later SA. METHODS: Among the women who were ever pregnant in the Health Examinees Study (HEXA), which was one of the cohorts studied in the KoGES (Korean Genome and Epidemiology Study) from 2004 to 2012 (N = 80,447), the likelihood of SA based on pre-pregnancy BMI, classified by the criteria for Asians (Underweight: <18.5 kg/m2; Normal range: 18.5-22.9 kg/m2; Overweight at risk: 23-24.9 kg/m2; Obese I: 25-29.9 kg/m2; Obese II: ≥30 kg/m2), was presented as odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression models. RESULTS: Being underweight or obese relative to the normal weight range was associated with a higher likelihood of SA (OR = 1.10 [95% CI = 1.05-1.15] in underweight women and OR = 1.06 [95% CI = 0.96-1.16] in obese women), and this effect was much greater in women who experienced recurrent SAs (for three or more SAs: OR = 1.29 [95% CI 1.14-1.46] in underweight women and OR = 1.39 [95% CI 1.09-1.78] in obese women). Obesity was associated with an increased likelihood of SA at a younger age (≤25 years), whereas underweight was associated with an increased OR of SA at an older age (≥26 years). DISCUSSION: As this study was conducted with baseline data of original cohort which focused on other chronic diseases, recall for previous pregnancy-related information might be less accurate. However, this study shows strength in its large size and prospective potential. CONCLUSIONS: Pre-pregnancy BMI at ages 18-20 years revealed a U-shaped association with SA, and underweight and obese women showed increased likelihood for SA during different age periods. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/26403183/Body_mass_index_at_age_18_20_and_later_risk_of_spontaneous_abortion_in_the_Health_Examinees_Study__HEXA__ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-015-0665-2 DB - PRIME DP - Unbound Medicine ER -