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The joint effect of asbestos exposure, tobacco smoking and alcohol drinking on laryngeal cancer risk: evidence from the French population-based case-control study, ICARE.
Occup Environ Med. 2016 Jan; 73(1):28-33.OE

Abstract

OBJECTIVE

The objective of the study was to investigate the joint effect of occupational exposure to asbestos, and tobacco and alcohol consumption, on the risk of laryngeal cancer among men.

METHODS

We used data from a large population-based case-control study conducted in France. We estimated two-way and three-way interactions between asbestos exposure (never vs ever exposed), tobacco consumption (<20 vs. ≥20 pack-years) and alcohol consumption (<5 vs. ≥5 drinks per day). The interaction on an additive scale was assessed by estimating the relative excess risk due to interaction (RERI) and the attributable proportion due to interaction, and the interaction on a multiplicative scale was assessed by estimating the multiplicative interaction parameter (ψ). Multiplicative interactions were also assessed using fractional polynomials for alcohol drinking, tobacco smoking and asbestos exposure.

RESULTS

When compared with light-to-moderate smokers and drinkers never exposed to asbestos, the increase in laryngeal cancer risk was smallest among light-to-moderate drinkers and smokers exposed to asbestos (OR=2.23 (1.08 to 4.60)), and highest among heavy smokers and drinkers ever exposed to asbestos (OR=69.39 (35.54 to 135.5)). We found an additive joint effect between asbestos exposure and alcohol consumption (RERI=4.75 (-4.29 to 11.12)), whereas we observed a more than additive joint effect between asbestos exposure and tobacco consumption (RERI=8.50 (0.71 to 23.81)), as well as between asbestos exposure, and tobacco and alcohol consumption (RERI=26.57 (11.52 to 67.88)). However, our results did not suggest any interaction on a multiplicative scale.

CONCLUSIONS

Our results suggest that asbestos exposure, in combination with tobacco and alcohol exposure, accounted for a substantial number of laryngeal cancer cases. Our findings therefore highlight the need for prevention in activities, such as construction work, where exposure to asbestos-containing materials remains.

Authors+Show Affiliations

Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.Inserm U 1085-IRSET, Pointe-à-Pitre, France University of Rennes 1, Rennes, France.Inserm UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Descartes, Paris, France.Inserm UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Sud 11, Kremlin-Bicêtre, France.Inserm UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Sud 11, Kremlin-Bicêtre, France.Inserm Epidemiologic Cohorts Unit-UMS 011 INSERM-UVSQ, Villejuif, France University of Versailles St-Quentin, Villejuif, France.Inserm Epidemiologic Cohorts Unit-UMS 011 INSERM-UVSQ, Villejuif, France University of Versailles St-Quentin, Villejuif, France.Inserm Epidemiologic Cohorts Unit-UMS 011 INSERM-UVSQ, Villejuif, France University of Versailles St-Quentin, Villejuif, France.Inserm UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Sud 11, Kremlin-Bicêtre, France.Unité Mixte de Recherche Épidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1, Lyon, France.Isère Cancer Registry, Grenoble, France.Inserm UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France University of Paris Sud 11, Kremlin-Bicêtre, France.Inserm U 1085-IRSET, Pointe-à-Pitre, France University of Rennes 1, Rennes, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26403532

Citation

Menvielle, Gwenn, et al. "The Joint Effect of Asbestos Exposure, Tobacco Smoking and Alcohol Drinking On Laryngeal Cancer Risk: Evidence From the French Population-based Case-control Study, ICARE." Occupational and Environmental Medicine, vol. 73, no. 1, 2016, pp. 28-33.
Menvielle G, Fayossé A, Radoï L, et al. The joint effect of asbestos exposure, tobacco smoking and alcohol drinking on laryngeal cancer risk: evidence from the French population-based case-control study, ICARE. Occup Environ Med. 2016;73(1):28-33.
Menvielle, G., Fayossé, A., Radoï, L., Guida, F., Sanchez, M., Carton, M., Cyr, D., Schmaus, A., Cénée, S., Fevotte, J., Delafosse, P., Stücker, I., & Luce, D. (2016). The joint effect of asbestos exposure, tobacco smoking and alcohol drinking on laryngeal cancer risk: evidence from the French population-based case-control study, ICARE. Occupational and Environmental Medicine, 73(1), 28-33. https://doi.org/10.1136/oemed-2015-102954
Menvielle G, et al. The Joint Effect of Asbestos Exposure, Tobacco Smoking and Alcohol Drinking On Laryngeal Cancer Risk: Evidence From the French Population-based Case-control Study, ICARE. Occup Environ Med. 2016;73(1):28-33. PubMed PMID: 26403532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The joint effect of asbestos exposure, tobacco smoking and alcohol drinking on laryngeal cancer risk: evidence from the French population-based case-control study, ICARE. AU - Menvielle,Gwenn, AU - Fayossé,Aurore, AU - Radoï,Loredana, AU - Guida,Florence, AU - Sanchez,Marie, AU - Carton,Matthieu, AU - Cyr,Diane, AU - Schmaus,Annie, AU - Cénée,Sylvie, AU - Fevotte,Joëlle, AU - Delafosse,Patricia, AU - Stücker,Isabelle, AU - Luce,Danièle, AU - ,, Y1 - 2015/09/24/ PY - 2015/03/16/received PY - 2015/08/30/accepted PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/4/8/medline SP - 28 EP - 33 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 73 IS - 1 N2 - OBJECTIVE: The objective of the study was to investigate the joint effect of occupational exposure to asbestos, and tobacco and alcohol consumption, on the risk of laryngeal cancer among men. METHODS: We used data from a large population-based case-control study conducted in France. We estimated two-way and three-way interactions between asbestos exposure (never vs ever exposed), tobacco consumption (<20 vs. ≥20 pack-years) and alcohol consumption (<5 vs. ≥5 drinks per day). The interaction on an additive scale was assessed by estimating the relative excess risk due to interaction (RERI) and the attributable proportion due to interaction, and the interaction on a multiplicative scale was assessed by estimating the multiplicative interaction parameter (ψ). Multiplicative interactions were also assessed using fractional polynomials for alcohol drinking, tobacco smoking and asbestos exposure. RESULTS: When compared with light-to-moderate smokers and drinkers never exposed to asbestos, the increase in laryngeal cancer risk was smallest among light-to-moderate drinkers and smokers exposed to asbestos (OR=2.23 (1.08 to 4.60)), and highest among heavy smokers and drinkers ever exposed to asbestos (OR=69.39 (35.54 to 135.5)). We found an additive joint effect between asbestos exposure and alcohol consumption (RERI=4.75 (-4.29 to 11.12)), whereas we observed a more than additive joint effect between asbestos exposure and tobacco consumption (RERI=8.50 (0.71 to 23.81)), as well as between asbestos exposure, and tobacco and alcohol consumption (RERI=26.57 (11.52 to 67.88)). However, our results did not suggest any interaction on a multiplicative scale. CONCLUSIONS: Our results suggest that asbestos exposure, in combination with tobacco and alcohol exposure, accounted for a substantial number of laryngeal cancer cases. Our findings therefore highlight the need for prevention in activities, such as construction work, where exposure to asbestos-containing materials remains. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/26403532/The_joint_effect_of_asbestos_exposure_tobacco_smoking_and_alcohol_drinking_on_laryngeal_cancer_risk:_evidence_from_the_French_population_based_case_control_study_ICARE_ L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&amp;pmid=26403532 DB - PRIME DP - Unbound Medicine ER -