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Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?
Cell Mol Life Sci. 2015 Dec; 72(24):4795-805.CM

Abstract

Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation.

Authors+Show Affiliations

Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, Cambridge, CB2 0QH, UK. nsdgroot@mrc-lmb.cam.ac.uk. Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. nsdgroot@mrc-lmb.cam.ac.uk.Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, Cambridge, CB2 0QH, UK. marc.torrent@vhir.org. Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. marc.torrent@vhir.org. Vall d'Hebron Research Institute (VHIR), Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain. marc.torrent@vhir.org.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26403788

Citation

de Groot, Natalia Sánchez, and Marc Torrent Burgas. "Is Membrane Homeostasis the Missing Link Between Inflammation and Neurodegenerative Diseases?" Cellular and Molecular Life Sciences : CMLS, vol. 72, no. 24, 2015, pp. 4795-805.
de Groot NS, Burgas MT. Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? Cell Mol Life Sci. 2015;72(24):4795-805.
de Groot, N. S., & Burgas, M. T. (2015). Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? Cellular and Molecular Life Sciences : CMLS, 72(24), 4795-805. https://doi.org/10.1007/s00018-015-2038-4
de Groot NS, Burgas MT. Is Membrane Homeostasis the Missing Link Between Inflammation and Neurodegenerative Diseases. Cell Mol Life Sci. 2015;72(24):4795-805. PubMed PMID: 26403788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? AU - de Groot,Natalia Sánchez, AU - Burgas,Marc Torrent, Y1 - 2015/09/24/ PY - 2015/06/15/received PY - 2015/09/03/accepted PY - 2015/08/16/revised PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/3/5/medline KW - Membrane KW - Microglia KW - Neurodegenerative disease KW - Neuroinflammation KW - Protein aggregation SP - 4795 EP - 805 JF - Cellular and molecular life sciences : CMLS JO - Cell. Mol. Life Sci. VL - 72 IS - 24 N2 - Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation. SN - 1420-9071 UR - https://www.unboundmedicine.com/medline/citation/26403788/Is_membrane_homeostasis_the_missing_link_between_inflammation_and_neurodegenerative_diseases L2 - https://doi.org/10.1007/s00018-015-2038-4 DB - PRIME DP - Unbound Medicine ER -