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OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF POLYPOIDAL CHOROIDAL VASCULOPATHY AND POLYPOIDAL CHOROIDAL NEOVASCULARIZATION.
Retina. 2015 Nov; 35(11):2265-74.R

Abstract

PURPOSE

To describe the use of optical coherence tomography angiography (OCT-A) for evaluating the spectrum of polypoidal vascular diseases.

METHODS

Retrospective observational case series of seven patients with polypoidal choroidal vasculopathy (three cases) or polypoidal choroidal neovascularization (four cases). Optical coherence tomography angiography information was acquired using two different OCT-A devices (the Optovue RTVue XR Avanti SD-OCT and the Spectralis OCT angiography). Flow signals within branching vascular networks, type 1 neovascularization and polyps were evaluated. Comparisons were made between en face and cross-sectional OCT-A images. Vascular information from OCT-A was also compared with indocyanine green angiography.

RESULTS

En face images from OCT-A provided anatomical information about branching vascular networks that were comparable to indocyanine green angiography. Polyps were poorly resolved on en face OCT-A images but were clearly defined on cross-sectional OCT-A images. Cross-sectional OCT-A revealed flow signals within focal regions of the polyps with a significant portion of the polyp lumen being devoid of flow signal. Flow signals from cross-sectional OCT-A images also showed that branching vascular networks, type 1 neovascularization, and polyps were confined to the anatomic compartment between the retinal pigment epithelium and Bruch's membrane. It was not possible to detect leakage on en face or cross-sectional OCT-A.

CONCLUSION

The combination of en face and cross-sectional OCT-A images provides anatomical information about polypoidal structures that is comparable to indocyanine green angiography. OCT-A may be a useful modality for the management of polypoidal diseases. However, the limitations of OCT-A identified in this study suggest that it is not a replacement for indocyanine green angiography.

Authors+Show Affiliations

*Vitreous Retina Macula Consultants of New York, New York, New York; †The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; ‡Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan; §Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Sciences, Lions Eye Institute, University of Western Australia, Perth, Australia; and ¶Department of Ophthalmology, New York University School of Medicine, New York, New York.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26405770

Citation

Inoue, Maiko, et al. "OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY of POLYPOIDAL CHOROIDAL VASCULOPATHY and POLYPOIDAL CHOROIDAL NEOVASCULARIZATION." Retina (Philadelphia, Pa.), vol. 35, no. 11, 2015, pp. 2265-74.
Inoue M, Balaratnasingam C, Freund KB. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF POLYPOIDAL CHOROIDAL VASCULOPATHY AND POLYPOIDAL CHOROIDAL NEOVASCULARIZATION. Retina. 2015;35(11):2265-74.
Inoue, M., Balaratnasingam, C., & Freund, K. B. (2015). OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF POLYPOIDAL CHOROIDAL VASCULOPATHY AND POLYPOIDAL CHOROIDAL NEOVASCULARIZATION. Retina (Philadelphia, Pa.), 35(11), 2265-74. https://doi.org/10.1097/IAE.0000000000000777
Inoue M, Balaratnasingam C, Freund KB. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY of POLYPOIDAL CHOROIDAL VASCULOPATHY and POLYPOIDAL CHOROIDAL NEOVASCULARIZATION. Retina. 2015;35(11):2265-74. PubMed PMID: 26405770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF POLYPOIDAL CHOROIDAL VASCULOPATHY AND POLYPOIDAL CHOROIDAL NEOVASCULARIZATION. AU - Inoue,Maiko, AU - Balaratnasingam,Chandrakumar, AU - Freund,K Bailey, PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/5/21/medline SP - 2265 EP - 74 JF - Retina (Philadelphia, Pa.) JO - Retina VL - 35 IS - 11 N2 - PURPOSE: To describe the use of optical coherence tomography angiography (OCT-A) for evaluating the spectrum of polypoidal vascular diseases. METHODS: Retrospective observational case series of seven patients with polypoidal choroidal vasculopathy (three cases) or polypoidal choroidal neovascularization (four cases). Optical coherence tomography angiography information was acquired using two different OCT-A devices (the Optovue RTVue XR Avanti SD-OCT and the Spectralis OCT angiography). Flow signals within branching vascular networks, type 1 neovascularization and polyps were evaluated. Comparisons were made between en face and cross-sectional OCT-A images. Vascular information from OCT-A was also compared with indocyanine green angiography. RESULTS: En face images from OCT-A provided anatomical information about branching vascular networks that were comparable to indocyanine green angiography. Polyps were poorly resolved on en face OCT-A images but were clearly defined on cross-sectional OCT-A images. Cross-sectional OCT-A revealed flow signals within focal regions of the polyps with a significant portion of the polyp lumen being devoid of flow signal. Flow signals from cross-sectional OCT-A images also showed that branching vascular networks, type 1 neovascularization, and polyps were confined to the anatomic compartment between the retinal pigment epithelium and Bruch's membrane. It was not possible to detect leakage on en face or cross-sectional OCT-A. CONCLUSION: The combination of en face and cross-sectional OCT-A images provides anatomical information about polypoidal structures that is comparable to indocyanine green angiography. OCT-A may be a useful modality for the management of polypoidal diseases. However, the limitations of OCT-A identified in this study suggest that it is not a replacement for indocyanine green angiography. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/26405770/OPTICAL_COHERENCE_TOMOGRAPHY_ANGIOGRAPHY_OF_POLYPOIDAL_CHOROIDAL_VASCULOPATHY_AND_POLYPOIDAL_CHOROIDAL_NEOVASCULARIZATION_ L2 - https://doi.org/10.1097/IAE.0000000000000777 DB - PRIME DP - Unbound Medicine ER -