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Computational hemodynamics of portal vein hypertension in hepatic cirrhosis patients.
Biomed Mater Eng. 2015; 26 Suppl 1:S233-43.BM

Abstract

Portal vein hypertension generally occurs in liver diseases like hepatic cirrhosis. It causes hemodynamic changes that are closely related to liver disease. At advanced stages of hepatic cirrhosis, portal vein hypertension leads to the atrophy of the right lobe of the liver and the hypertrophy of the left lobe through a process that has not yet been fully explained. Based on the hemodynamic changes that are known to occur, we hypothesize that liver volume is related to the distribution of blood flowing from the splenic vein (SV) that carries hepatotrophic factors from the spleen and pancreas. We studied blood flow in the portal vein system to validate this hypothesis through in vitro experimentation and a computational fluid dynamics (CFD) analysis involving both simplified and patient-specific models based on four healthy subjects and two patients with liver cirrhosis. The results confirmed the hypothesis that right-lobe atrophy is significantly influenced by the distribution of blood from the SV. Moreover, the patients with liver cirrhosis had a significantly larger mass fraction of spleen-derived blood in the left portal vein branch (LPV) than healthy subjects, a result consistent with right-lobe atrophy and left-lobe hypertrophy.

Authors+Show Affiliations

State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an City, Shaanxi Province, P.R. China.State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an City, Shaanxi Province, P.R. China.State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an City, Shaanxi Province, P.R. China.Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an City, Shaanxi Province, P.R. China.Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an City, Shaanxi Province, P.R. China.Department of Radiology, Huaihe Hospital Affiliated to Henan University, Kaifeng City, Henan Province, P.R. China.Department of Radiology, Huaihe Hospital Affiliated to Henan University, Kaifeng City, Henan Province, P.R. China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26406008

Citation

Li, X, et al. "Computational Hemodynamics of Portal Vein Hypertension in Hepatic Cirrhosis Patients." Bio-medical Materials and Engineering, vol. 26 Suppl 1, 2015, pp. S233-43.
Li X, Wang XK, Chen B, et al. Computational hemodynamics of portal vein hypertension in hepatic cirrhosis patients. Biomed Mater Eng. 2015;26 Suppl 1:S233-43.
Li, X., Wang, X. K., Chen, B., Pu, Y. S., Li, Z. F., Nie, P., & Su, K. (2015). Computational hemodynamics of portal vein hypertension in hepatic cirrhosis patients. Bio-medical Materials and Engineering, 26 Suppl 1, S233-43. https://doi.org/10.3233/BME-151310
Li X, et al. Computational Hemodynamics of Portal Vein Hypertension in Hepatic Cirrhosis Patients. Biomed Mater Eng. 2015;26 Suppl 1:S233-43. PubMed PMID: 26406008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Computational hemodynamics of portal vein hypertension in hepatic cirrhosis patients. AU - Li,X, AU - Wang,X K, AU - Chen,B, AU - Pu,Y S, AU - Li,Z F, AU - Nie,P, AU - Su,K, PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/7/13/medline KW - Portal vein hypertension KW - hemodynamics KW - hepatotrophic factor KW - splenic vein SP - S233 EP - 43 JF - Bio-medical materials and engineering JO - Biomed Mater Eng VL - 26 Suppl 1 N2 - Portal vein hypertension generally occurs in liver diseases like hepatic cirrhosis. It causes hemodynamic changes that are closely related to liver disease. At advanced stages of hepatic cirrhosis, portal vein hypertension leads to the atrophy of the right lobe of the liver and the hypertrophy of the left lobe through a process that has not yet been fully explained. Based on the hemodynamic changes that are known to occur, we hypothesize that liver volume is related to the distribution of blood flowing from the splenic vein (SV) that carries hepatotrophic factors from the spleen and pancreas. We studied blood flow in the portal vein system to validate this hypothesis through in vitro experimentation and a computational fluid dynamics (CFD) analysis involving both simplified and patient-specific models based on four healthy subjects and two patients with liver cirrhosis. The results confirmed the hypothesis that right-lobe atrophy is significantly influenced by the distribution of blood from the SV. Moreover, the patients with liver cirrhosis had a significantly larger mass fraction of spleen-derived blood in the left portal vein branch (LPV) than healthy subjects, a result consistent with right-lobe atrophy and left-lobe hypertrophy. SN - 1878-3619 UR - https://www.unboundmedicine.com/medline/citation/26406008/Computational_hemodynamics_of_portal_vein_hypertension_in_hepatic_cirrhosis_patients_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/BME-151310 DB - PRIME DP - Unbound Medicine ER -