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Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's disease.
J Parkinsons Dis. 2015; 5(3):561-7.JP

Abstract

BACKGROUND

Specific MR sequences have been able to identify the loss of neuromelanin in the substantia nigra (SN) of early stage Parkinson's disease (PD) patients. Since this technique may have a significant impact in clinical patient management, easy and widely available imaging analysis is needed for routine use.

OBJECTIVE

In this study we compared a quantitative analysis with a visual assessment of SN neuromelanin-sensitive MR images in early stage PD patients, in terms of pattern changes recognition and diagnostic accuracy.

METHODS

The inclusion criteria were untreated "de novo" PD patients or a 2-5 year PD duration; in addition, age matched controls were enrolled. These were studied with a high-resolution T1-weighted MR imaging sequence at 3.0 Tesla to visualize neuromelanin. The primary outcome was the comparison of quantitative width measurement with visual assessment by experienced neuroradiologists of SN neuromelanin sensitive MR images for PD diagnosis.

RESULTS

A total of 12 "de novo" PD patients, 10 PD patients with 2-5 year disease duration and 10 healthy controls were evaluated. We obtained a good accuracy in discriminating early-stage PD patients from controls using either a quantitative width measurement of the T1 high signal or a simple visual image inspection of the SN region.

CONCLUSIONS

Visual inspection of neuromelanin-sensitive MR images by experienced neuroradiologists provides comparable results to quantitative width measurement in the detection of early stage PD SN changes and may become a useful tool in clinical practice.

Authors+Show Affiliations

Neurological Imaging Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal. Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.Neurological Imaging Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal.Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Portugal.Neurological Imaging Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Portugal.Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26406136

Citation

Reimão, Sofia, et al. "Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's Disease." Journal of Parkinson's Disease, vol. 5, no. 3, 2015, pp. 561-7.
Reimão S, Pita Lobo P, Neutel D, et al. Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's disease. J Parkinsons Dis. 2015;5(3):561-7.
Reimão, S., Pita Lobo, P., Neutel, D., Guedes, L. C., Coelho, M., Rosa, M. M., Ferreira, J., Abreu, D., Gonçalves, N., Morgado, C., Nunes, R. G., Campos, J., & Ferreira, J. J. (2015). Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's disease. Journal of Parkinson's Disease, 5(3), 561-7. https://doi.org/10.3233/JPD-150551
Reimão S, et al. Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's Disease. J Parkinsons Dis. 2015;5(3):561-7. PubMed PMID: 26406136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's disease. AU - Reimão,Sofia, AU - Pita Lobo,Patrícia, AU - Neutel,Dulce, AU - Guedes,Leonor Correia, AU - Coelho,Miguel, AU - Rosa,Mario M, AU - Ferreira,Joana, AU - Abreu,Daisy, AU - Gonçalves,Nilza, AU - Morgado,Carlos, AU - Nunes,Rita G, AU - Campos,Jorge, AU - Ferreira,Joaquim J, PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/7/22/medline KW - MRI KW - Neuromelanin KW - Parkinson’s disease KW - locus ceruleus KW - substantia nigra SP - 561 EP - 7 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 5 IS - 3 N2 - BACKGROUND: Specific MR sequences have been able to identify the loss of neuromelanin in the substantia nigra (SN) of early stage Parkinson's disease (PD) patients. Since this technique may have a significant impact in clinical patient management, easy and widely available imaging analysis is needed for routine use. OBJECTIVE: In this study we compared a quantitative analysis with a visual assessment of SN neuromelanin-sensitive MR images in early stage PD patients, in terms of pattern changes recognition and diagnostic accuracy. METHODS: The inclusion criteria were untreated "de novo" PD patients or a 2-5 year PD duration; in addition, age matched controls were enrolled. These were studied with a high-resolution T1-weighted MR imaging sequence at 3.0 Tesla to visualize neuromelanin. The primary outcome was the comparison of quantitative width measurement with visual assessment by experienced neuroradiologists of SN neuromelanin sensitive MR images for PD diagnosis. RESULTS: A total of 12 "de novo" PD patients, 10 PD patients with 2-5 year disease duration and 10 healthy controls were evaluated. We obtained a good accuracy in discriminating early-stage PD patients from controls using either a quantitative width measurement of the T1 high signal or a simple visual image inspection of the SN region. CONCLUSIONS: Visual inspection of neuromelanin-sensitive MR images by experienced neuroradiologists provides comparable results to quantitative width measurement in the detection of early stage PD SN changes and may become a useful tool in clinical practice. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/26406136/Quantitative_Analysis_Versus_Visual_Assessment_of_Neuromelanin_MR_Imaging_for_the_Diagnosis_of_Parkinson's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-150551 DB - PRIME DP - Unbound Medicine ER -