Tags

Type your tag names separated by a space and hit enter

Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens.
J Trauma Acute Care Surg. 2015 Oct; 79(4 Suppl 2):S121-9.JT

Abstract

BACKGROUND

This work was intended as a proof-of-principle study to help establish carbohydrate-derived fulvic acid (CHD-FA) as a safe and effective agent that can be deployed to prevent the onset of drug-resistant bacterial and fungal infections in military and civilian personnel experiencing traumatic wound.

METHODS

Minimum inhibitory concentrations for CHD-FA were established on a total of 500 clinical isolates representing wound-associated drug-sensitive and drug-resistant bacterial and fungal pathogens. The efficacy of early use of CHD-FA to enhance healing of wounds infected with methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa was evaluated in an in vivo rat model.

RESULTS

CHD-FA showed strong activity against a variety of bacterial and fungal pathogens with minimum inhibitory concentration values equal or less than 0.5%. Compared with infected but untreated wounds, improved wound healing upon CHD-FA treatment was observed in both infection models, demonstrated by wound surface area measurement, histopathologic examination, and expression profiling of wound healing genes. Up-regulation of proinflammatory cytokine interleukin 6 (IL-6) at Day 3 after infection was significantly dampened at Days 6 and 10 in the CHD-FA-treated wounds in both infection models, displaying an improved and accelerated wound healing.

CONCLUSION

CHD-FA is a promising topical remedy for drug-resistant wound infections. It accelerated the healing process of wounds infected with methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa in rats, which is linked to both its antimicrobial and anti-inflammatory properties.

Authors+Show Affiliations

From the Public Health Research Institute (Y.Z., P.P., G.D., E.D., M.H.L., M.S., S.P., D.S.P.), Rutgers Biomedical and Health Sciences, Newark, New Jersey; and Fulhold, Ltd. (S.L.), Ebene Mews, Mauritius.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26406424

Citation

Zhao, Yanan, et al. "Carbohydrate-derived Fulvic Acid Is a Highly Promising Topical Agent to Enhance Healing of Wounds Infected With Drug-resistant Pathogens." The Journal of Trauma and Acute Care Surgery, vol. 79, no. 4 Suppl 2, 2015, pp. S121-9.
Zhao Y, Paderu P, Delmas G, et al. Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. J Trauma Acute Care Surg. 2015;79(4 Suppl 2):S121-9.
Zhao, Y., Paderu, P., Delmas, G., Dolgov, E., Lee, M. H., Senter, M., Park, S., Leivers, S., & Perlin, D. S. (2015). Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. The Journal of Trauma and Acute Care Surgery, 79(4 Suppl 2), S121-9. https://doi.org/10.1097/TA.0000000000000737
Zhao Y, et al. Carbohydrate-derived Fulvic Acid Is a Highly Promising Topical Agent to Enhance Healing of Wounds Infected With Drug-resistant Pathogens. J Trauma Acute Care Surg. 2015;79(4 Suppl 2):S121-9. PubMed PMID: 26406424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. AU - Zhao,Yanan, AU - Paderu,Padmaja, AU - Delmas,Guillaume, AU - Dolgov,Enriko, AU - Lee,Min Hee, AU - Senter,Meredith, AU - Park,Steven, AU - Leivers,Stephen, AU - Perlin,David S, PY - 2015/9/26/entrez PY - 2015/9/26/pubmed PY - 2016/1/5/medline SP - S121 EP - 9 JF - The journal of trauma and acute care surgery JO - J Trauma Acute Care Surg VL - 79 IS - 4 Suppl 2 N2 - BACKGROUND: This work was intended as a proof-of-principle study to help establish carbohydrate-derived fulvic acid (CHD-FA) as a safe and effective agent that can be deployed to prevent the onset of drug-resistant bacterial and fungal infections in military and civilian personnel experiencing traumatic wound. METHODS: Minimum inhibitory concentrations for CHD-FA were established on a total of 500 clinical isolates representing wound-associated drug-sensitive and drug-resistant bacterial and fungal pathogens. The efficacy of early use of CHD-FA to enhance healing of wounds infected with methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa was evaluated in an in vivo rat model. RESULTS: CHD-FA showed strong activity against a variety of bacterial and fungal pathogens with minimum inhibitory concentration values equal or less than 0.5%. Compared with infected but untreated wounds, improved wound healing upon CHD-FA treatment was observed in both infection models, demonstrated by wound surface area measurement, histopathologic examination, and expression profiling of wound healing genes. Up-regulation of proinflammatory cytokine interleukin 6 (IL-6) at Day 3 after infection was significantly dampened at Days 6 and 10 in the CHD-FA-treated wounds in both infection models, displaying an improved and accelerated wound healing. CONCLUSION: CHD-FA is a promising topical remedy for drug-resistant wound infections. It accelerated the healing process of wounds infected with methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa in rats, which is linked to both its antimicrobial and anti-inflammatory properties. SN - 2163-0763 UR - https://www.unboundmedicine.com/medline/citation/26406424/Carbohydrate_derived_fulvic_acid_is_a_highly_promising_topical_agent_to_enhance_healing_of_wounds_infected_with_drug_resistant_pathogens_ L2 - http://dx.doi.org/10.1097/TA.0000000000000737 DB - PRIME DP - Unbound Medicine ER -