Citation
Hossen, Virginie, et al. "Contribution to the Risk Characterization of Ciguatoxins: LOAEL Estimated From Eight Ciguatera Fish Poisoning Events in Guadeloupe (French West Indies)." Environmental Research, vol. 143, no. Pt B, 2015, pp. 100-8.
Hossen V, Soliño L, Leroy P, et al. Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies). Environ Res. 2015;143(Pt B):100-8.
Hossen, V., Soliño, L., Leroy, P., David, E., Velge, P., Dragacci, S., Krys, S., Flores Quintana, H., & Diogène, J. (2015). Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies). Environmental Research, 143(Pt B), 100-8. https://doi.org/10.1016/j.envres.2015.09.014
Hossen V, et al. Contribution to the Risk Characterization of Ciguatoxins: LOAEL Estimated From Eight Ciguatera Fish Poisoning Events in Guadeloupe (French West Indies). Environ Res. 2015;143(Pt B):100-8. PubMed PMID: 26409497.
TY - JOUR
T1 - Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).
AU - Hossen,Virginie,
AU - Soliño,Lucia,
AU - Leroy,Patricia,
AU - David,Eric,
AU - Velge,Pierre,
AU - Dragacci,Sylviane,
AU - Krys,Sophie,
AU - Flores Quintana,Harold,
AU - Diogène,Jorge,
Y1 - 2015/09/26/
PY - 2015/03/18/received
PY - 2015/07/30/revised
PY - 2015/09/14/accepted
PY - 2015/9/28/entrez
PY - 2015/9/28/pubmed
PY - 2016/3/16/medline
KW - Ciguatera fish poisoning
KW - Ciguatoxins
KW - Guadeloupe
KW - LOAEL
KW - Mouse bioassay
KW - Neuro-2A cell-based assay
SP - 100
EP - 8
JF - Environmental research
JO - Environ Res
VL - 143
IS - Pt B
N2 - From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the presence of ciguatoxins (CTXs) was indicated in meal remnants and in uncooked fish by the mouse bioassay (MBA). Caribbean ciguatoxins (C-CTXs) were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Using a cell-based assay (CBA), and the only available standard Pacific ciguatoxin-1 (P-CTX-1), the lowest toxins level detected in fish samples causing CFP was 0.022 µg P-CTX-1 equivalent (eq.)·kg(-1) fish. Epidemiological and consumption data were compiled for most of the individuals afflicted, and complete data for establishing the lowest observable adverse effects level (LOAEL) were obtained from 8 CFP events involving 21 individuals. Based on toxin intakes, the LOAEL was estimated at 4.2 ng P-CTX-1 eq./individual corresponding to 48. 4 pg P-CTX-1 eq.kg(-1) body weight (bw). Although based on limited data, these results are consistent with the conclusions of the European Food Safety Authority (EFSA) opinion which indicates that a level of 0.01 µg P-CTX-1 eq.kg(-1) fish, regardless of source, should not exert effects in sensitive individuals when consuming a single meal. The calculated LOAEL is also consistent with the U.S. Food and Drug Administration guidance levels for CTXs (0.1 µg C-CTX-1 eq.kg(-1) and 0.01 µg P-CTX-1 eq.kg(-1) fish).
SN - 1096-0953
UR - https://www.unboundmedicine.com/medline/citation/26409497/Contribution_to_the_risk_characterization_of_ciguatoxins:_LOAEL_estimated_from_eight_ciguatera_fish_poisoning_events_in_Guadeloupe__French_West_Indies__
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(15)30084-0
DB - PRIME
DP - Unbound Medicine
ER -