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Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).
Environ Res. 2015 Nov; 143(Pt B):100-8.ER

Abstract

From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the presence of ciguatoxins (CTXs) was indicated in meal remnants and in uncooked fish by the mouse bioassay (MBA). Caribbean ciguatoxins (C-CTXs) were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Using a cell-based assay (CBA), and the only available standard Pacific ciguatoxin-1 (P-CTX-1), the lowest toxins level detected in fish samples causing CFP was 0.022 µg P-CTX-1 equivalent (eq.)·kg(-1) fish. Epidemiological and consumption data were compiled for most of the individuals afflicted, and complete data for establishing the lowest observable adverse effects level (LOAEL) were obtained from 8 CFP events involving 21 individuals. Based on toxin intakes, the LOAEL was estimated at 4.2 ng P-CTX-1 eq./individual corresponding to 48. 4 pg P-CTX-1 eq.kg(-1) body weight (bw). Although based on limited data, these results are consistent with the conclusions of the European Food Safety Authority (EFSA) opinion which indicates that a level of 0.01 µg P-CTX-1 eq.kg(-1) fish, regardless of source, should not exert effects in sensitive individuals when consuming a single meal. The calculated LOAEL is also consistent with the U.S. Food and Drug Administration guidance levels for CTXs (0.1 µg C-CTX-1 eq.kg(-1) and 0.01 µg P-CTX-1 eq.kg(-1) fish).

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Authors+Show Affiliations

Hossen V
Université Paris-Est, ANSES-Laboratory for Food Safety, National Reference Laboratory for the Control of Marine biotoxins, 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.
Soliño L
Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, Sant Carles de la Rapita, Spain.
Leroy P
Université Paris-Est, ANSES-Laboratory for Food Safety, National Reference Laboratory for the Control of Marine biotoxins, 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.
David E
Ministry of Agriculture, Direction de l'Alimentation de l'Agriculture et de la Forêt de Guadeloupe, Abymes, France.
Velge P
Ministry of Agriculture, General Directorate for Food, Paris, France.
Dragacci S
Université Paris-Est, ANSES-Laboratory for Food Safety, National Reference Laboratory for the Control of Marine biotoxins, 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France. Electronic address: Sylviane.dragacci@anses.fr.
Krys S
Université Paris-Est, ANSES-Laboratory for Food Safety, National Reference Laboratory for the Control of Marine biotoxins, 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.
Flores Quintana H
U.S. Food and Drug Administration (FDA), Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA.
Diogène J
Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, Sant Carles de la Rapita, Spain.

MeSH

AnimalsCell Line, TumorCell SurvivalCiguatera PoisoningCiguatoxinsDose-Response Relationship, DrugFishesGuadeloupeHumansMaleMiceSeafoodToxicity Tests

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26409497

Citation

Hossen, Virginie, et al. "Contribution to the Risk Characterization of Ciguatoxins: LOAEL Estimated From Eight Ciguatera Fish Poisoning Events in Guadeloupe (French West Indies)." Environmental Research, vol. 143, no. Pt B, 2015, pp. 100-8.
Hossen V, Soliño L, Leroy P, et al. Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies). Environ Res. 2015;143(Pt B):100-8.
Hossen, V., Soliño, L., Leroy, P., David, E., Velge, P., Dragacci, S., Krys, S., Flores Quintana, H., & Diogène, J. (2015). Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies). Environmental Research, 143(Pt B), 100-8. https://doi.org/10.1016/j.envres.2015.09.014
Hossen V, et al. Contribution to the Risk Characterization of Ciguatoxins: LOAEL Estimated From Eight Ciguatera Fish Poisoning Events in Guadeloupe (French West Indies). Environ Res. 2015;143(Pt B):100-8. PubMed PMID: 26409497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies). AU - Hossen,Virginie, AU - Soliño,Lucia, AU - Leroy,Patricia, AU - David,Eric, AU - Velge,Pierre, AU - Dragacci,Sylviane, AU - Krys,Sophie, AU - Flores Quintana,Harold, AU - Diogène,Jorge, Y1 - 2015/09/26/ PY - 2015/03/18/received PY - 2015/07/30/revised PY - 2015/09/14/accepted PY - 2015/9/28/entrez PY - 2015/9/28/pubmed PY - 2016/3/16/medline KW - Ciguatera fish poisoning KW - Ciguatoxins KW - Guadeloupe KW - LOAEL KW - Mouse bioassay KW - Neuro-2A cell-based assay SP - 100 EP - 8 JF - Environmental research JO - Environ Res VL - 143 IS - Pt B N2 - From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the presence of ciguatoxins (CTXs) was indicated in meal remnants and in uncooked fish by the mouse bioassay (MBA). Caribbean ciguatoxins (C-CTXs) were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Using a cell-based assay (CBA), and the only available standard Pacific ciguatoxin-1 (P-CTX-1), the lowest toxins level detected in fish samples causing CFP was 0.022 µg P-CTX-1 equivalent (eq.)·kg(-1) fish. Epidemiological and consumption data were compiled for most of the individuals afflicted, and complete data for establishing the lowest observable adverse effects level (LOAEL) were obtained from 8 CFP events involving 21 individuals. Based on toxin intakes, the LOAEL was estimated at 4.2 ng P-CTX-1 eq./individual corresponding to 48. 4 pg P-CTX-1 eq.kg(-1) body weight (bw). Although based on limited data, these results are consistent with the conclusions of the European Food Safety Authority (EFSA) opinion which indicates that a level of 0.01 µg P-CTX-1 eq.kg(-1) fish, regardless of source, should not exert effects in sensitive individuals when consuming a single meal. The calculated LOAEL is also consistent with the U.S. Food and Drug Administration guidance levels for CTXs (0.1 µg C-CTX-1 eq.kg(-1) and 0.01 µg P-CTX-1 eq.kg(-1) fish). SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/26409497/Contribution_to_the_risk_characterization_of_ciguatoxins:_LOAEL_estimated_from_eight_ciguatera_fish_poisoning_events_in_Guadeloupe__French_West_Indies__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(15)30084-0 DB - PRIME DP - Unbound Medicine ER -