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Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women.
Clin Hemorheol Microcirc 2016; 62(1):45-54CH

Abstract

OBJECTIVE

Structure and mechanical properties of red blood cells are markedly influenced by pathophysiology of many diseases which in turn potentially impair microcirculatory blood flow. The physiological association between blood rheological parameters and red blood cell indices was investigated in otherwise healthy unselected mid-age women prior to elective gynaecological surgery.

METHODS

Red Blood Cell-deformability (RBC 1.2, 3.0; 6.0, 12.0; 30.0, 60.0) during exposure to low (RBC 1.2, 3.0), moderate (RBC 16.0, 12.0) and high shear forces (RBC 30.0, 60.0; Rheodyn; Myrenne), -aggregation (MA1; Myrenne) during low shear (E1; 4-1 S) and in stasis (E0) and plasma viscosity (Pv; KSV 1; Fresenius) were correlated with red blood cell indices (RBC-I: MCV, MCH and MCHC) and subjects' characteristics in 286 healthy women the day before undergoing gynaecologic standard surgery. Women with known pregnancy, malign-, infective-, chronic-disease or extreme BMI (<16; >40 Kg/m2) were excluded from this trial.

RESULTS

From June 2014 to December 2014 a total of 286 healthy women (age: 46.5±17.6 y; BMI: 25.5±5.2 kg/m2) were eligible for inclusion into this prospective evaluation. Pv (mean±SD: 1.17±0.12 mPa s) and RBC aggregation (E0:12.6±6.3; E1:17.9±7.3) were not significantly correlated with RBC-I but with age and BMI. In contrast, RBC-deformability correlated significantly with MCV and MCH but significantly inversely correlated with MCHC. Deformability significantly increased with age but was unaffected by BMI of women. The correlation between RBC-I and RBC deformability was most remarkable during moderate shear force exposure. Neither haemoglobin nor haematocrit were correlated with RBC deformability or RBC-I.

CONCLUSIONS

Cell volume and haemoglobin content had a strong impact on deformability in apparently healthy mid age women, whereas low MCHC and large MCV were associated with an increase in deformability while high MCHC and small MCV correlated with increased rigidity of RBC. BMI had no impact on deformability while age was associated with an increase in all determinants of blood viscosity. RBC aggregability was not affected by MCV, MCHC or MCH in mid-age women.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, St. Vinzenz Hospital, Hanau, Germany. Institut of Coagulation Disorders in Obstetrics and Gynaecology, Hausen, Germany.Department of Obstetrics and Gynaecology, St. Vinzenz Hospital, Hanau, Germany. Institut of Coagulation Disorders in Obstetrics and Gynaecology, Hausen, Germany.Department of Obstetrics and Gynaecology, St. Vinzenz Hospital, Hanau, Germany. Institut of Coagulation Disorders in Obstetrics and Gynaecology, Hausen, Germany.Institut of Coagulation Disorders in Obstetrics and Gynaecology, Hausen, Germany. Democritus University of Thrace, Department of Obstetrics and Gynaecology, Alexandroupolis, Greece.Department of Obstetrics and Gynaecology, RWTH University of Aachen, Germany.Department of Obstetrics and Gynaecology, City Hospital of Aschaffenburg, Aschaffenburg, Germany. Institut of Coagulation Disorders in Obstetrics and Gynaecology, Hausen, Germany.Department of Obstetrics and Gynaecology, City Hospital of Aschaffenburg, Aschaffenburg, Germany. Institut of Coagulation Disorders in Obstetrics and Gynaecology, Hausen, Germany. Department of Obstetrics and Gynaecology, University of Debrecen, Hungary.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26410854

Citation

von Tempelhoff, Georg-Friedrich, et al. "Correlation Between Blood Rheological Properties and Red Blood Cell indices(MCH, MCV, MCHC) in Healthy Women." Clinical Hemorheology and Microcirculation, vol. 62, no. 1, 2016, pp. 45-54.
von Tempelhoff GF, Schelkunov O, Demirhan A, et al. Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women. Clin Hemorheol Microcirc. 2016;62(1):45-54.
von Tempelhoff, G. F., Schelkunov, O., Demirhan, A., Tsikouras, P., Rath, W., Velten, E., & Csorba, R. (2016). Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women. Clinical Hemorheology and Microcirculation, 62(1), pp. 45-54. doi:10.3233/CH-151944.
von Tempelhoff GF, et al. Correlation Between Blood Rheological Properties and Red Blood Cell indices(MCH, MCV, MCHC) in Healthy Women. Clin Hemorheol Microcirc. 2016;62(1):45-54. PubMed PMID: 26410854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women. AU - von Tempelhoff,Georg-Friedrich, AU - Schelkunov,Olga, AU - Demirhan,Attila, AU - Tsikouras,Panagiotis, AU - Rath,Werner, AU - Velten,Eva, AU - Csorba,Roland, PY - 2015/9/28/entrez PY - 2015/9/28/pubmed PY - 2016/11/15/medline KW - MCHC KW - MCV KW - Plasma viscosity KW - red blood cell aggregation KW - red blood cell deformability MCH SP - 45 EP - 54 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 62 IS - 1 N2 - OBJECTIVE: Structure and mechanical properties of red blood cells are markedly influenced by pathophysiology of many diseases which in turn potentially impair microcirculatory blood flow. The physiological association between blood rheological parameters and red blood cell indices was investigated in otherwise healthy unselected mid-age women prior to elective gynaecological surgery. METHODS: Red Blood Cell-deformability (RBC 1.2, 3.0; 6.0, 12.0; 30.0, 60.0) during exposure to low (RBC 1.2, 3.0), moderate (RBC 16.0, 12.0) and high shear forces (RBC 30.0, 60.0; Rheodyn; Myrenne), -aggregation (MA1; Myrenne) during low shear (E1; 4-1 S) and in stasis (E0) and plasma viscosity (Pv; KSV 1; Fresenius) were correlated with red blood cell indices (RBC-I: MCV, MCH and MCHC) and subjects' characteristics in 286 healthy women the day before undergoing gynaecologic standard surgery. Women with known pregnancy, malign-, infective-, chronic-disease or extreme BMI (<16; >40 Kg/m2) were excluded from this trial. RESULTS: From June 2014 to December 2014 a total of 286 healthy women (age: 46.5±17.6 y; BMI: 25.5±5.2 kg/m2) were eligible for inclusion into this prospective evaluation. Pv (mean±SD: 1.17±0.12 mPa s) and RBC aggregation (E0:12.6±6.3; E1:17.9±7.3) were not significantly correlated with RBC-I but with age and BMI. In contrast, RBC-deformability correlated significantly with MCV and MCH but significantly inversely correlated with MCHC. Deformability significantly increased with age but was unaffected by BMI of women. The correlation between RBC-I and RBC deformability was most remarkable during moderate shear force exposure. Neither haemoglobin nor haematocrit were correlated with RBC deformability or RBC-I. CONCLUSIONS: Cell volume and haemoglobin content had a strong impact on deformability in apparently healthy mid age women, whereas low MCHC and large MCV were associated with an increase in deformability while high MCHC and small MCV correlated with increased rigidity of RBC. BMI had no impact on deformability while age was associated with an increase in all determinants of blood viscosity. RBC aggregability was not affected by MCV, MCHC or MCH in mid-age women. SN - 1875-8622 UR - https://www.unboundmedicine.com/medline/citation/26410854/Correlation_between_blood_rheological_properties_and_red_blood_cell_indices_MCH_MCV_MCHC__in_healthy_women_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/CH-151944 DB - PRIME DP - Unbound Medicine ER -