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Composition, in vitro Cytotoxic, and Antimicrobial Activities of the Flower Essential Oil of Diospyros discolor from Taiwan.
Nat Prod Commun. 2015 Jul; 10(7):1311-4.NP

Abstract

This study investigated the chemical composition, in vitro cytotoxic, and antimicrobial activities of the essential oil isolated from the flower of Diospyros discolor from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Twenty-eight compounds were identified, representing 100% of the oil. The main components identified were (2Z,6E)-farnesol (35.0%), α-cadinol (10.9%), (E)-nerolidol (6.9%), α-humulene (6.0%), τ-cadinol (5.6%), β-caryophyllene (5.3%), and τ-muurolol (5.3%). The oil exhibited cytotoxic activity against human colon, liver, and lung cancer cells. The active compounds were β-caryophyllene, α-humulene, τ-cadinol, τ-muurolol, α-cadinol, and (2Z,6E)-farnesol. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited moderate to strong growth suppression against Bacillus cereus, Staphylococcus aureus, S. epidermidis, Escherichia coli, Enterobacter aerogenes, and Candida albicans, with inhibition zones of 40 to 52 mm and MIC values of 31.25-62.5 μg/mL, respectively. For the antimicrobial activities of the oil, the active compounds were determined to be α-cadinol, τ-cadinol, τ-muurolol and (2Z,6E)-farnesol.

Authors

Su YC
No affiliation info available
Hsu KP
No affiliation info available
Wang EI
No affiliation info available
Ho CL
No affiliation info available

MeSH

Anti-Infective AgentsDiospyrosDrug Screening Assays, AntitumorFlowersHT29 CellsHumansMicrobial Sensitivity TestsOils, VolatileTaiwan

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26411038

Citation

Su, Yu-Chang, et al. "Composition, in Vitro Cytotoxic, and Antimicrobial Activities of the Flower Essential Oil of Diospyros Discolor From Taiwan." Natural Product Communications, vol. 10, no. 7, 2015, pp. 1311-4.
Su YC, Hsu KP, Wang EI, et al. Composition, in vitro Cytotoxic, and Antimicrobial Activities of the Flower Essential Oil of Diospyros discolor from Taiwan. Nat Prod Commun. 2015;10(7):1311-4.
Su, Y. C., Hsu, K. P., Wang, E. I., & Ho, C. L. (2015). Composition, in vitro Cytotoxic, and Antimicrobial Activities of the Flower Essential Oil of Diospyros discolor from Taiwan. Natural Product Communications, 10(7), 1311-4.
Su YC, et al. Composition, in Vitro Cytotoxic, and Antimicrobial Activities of the Flower Essential Oil of Diospyros Discolor From Taiwan. Nat Prod Commun. 2015;10(7):1311-4. PubMed PMID: 26411038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition, in vitro Cytotoxic, and Antimicrobial Activities of the Flower Essential Oil of Diospyros discolor from Taiwan. AU - Su,Yu-Chang, AU - Hsu,Kuan-Ping, AU - Wang,Eugene I-Chen, AU - Ho,Chen-Lung, PY - 2015/9/29/entrez PY - 2015/9/29/pubmed PY - 2015/11/17/medline SP - 1311 EP - 4 JF - Natural product communications JO - Nat Prod Commun VL - 10 IS - 7 N2 - This study investigated the chemical composition, in vitro cytotoxic, and antimicrobial activities of the essential oil isolated from the flower of Diospyros discolor from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Twenty-eight compounds were identified, representing 100% of the oil. The main components identified were (2Z,6E)-farnesol (35.0%), α-cadinol (10.9%), (E)-nerolidol (6.9%), α-humulene (6.0%), τ-cadinol (5.6%), β-caryophyllene (5.3%), and τ-muurolol (5.3%). The oil exhibited cytotoxic activity against human colon, liver, and lung cancer cells. The active compounds were β-caryophyllene, α-humulene, τ-cadinol, τ-muurolol, α-cadinol, and (2Z,6E)-farnesol. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited moderate to strong growth suppression against Bacillus cereus, Staphylococcus aureus, S. epidermidis, Escherichia coli, Enterobacter aerogenes, and Candida albicans, with inhibition zones of 40 to 52 mm and MIC values of 31.25-62.5 μg/mL, respectively. For the antimicrobial activities of the oil, the active compounds were determined to be α-cadinol, τ-cadinol, τ-muurolol and (2Z,6E)-farnesol. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/26411038/Composition_in_vitro_Cytotoxic_and_Antimicrobial_Activities_of_the_Flower_Essential_Oil_of_Diospyros_discolor_from_Taiwan_ DB - PRIME DP - Unbound Medicine ER -