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Green tea and liver cancer risk: A meta-analysis of prospective cohort studies in Asian populations.
Nutrition 2016; 32(1):3-8N

Abstract

OBJECTIVES

The aim of this meta-analysis was to investigate whether an association existed between green tea consumption and the risk for liver cancer in prospective cohort studies in Asian populations.

METHODS

Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science, and the Chinese Bio-medicine Database published before April 2015. Study-specific risk estimates for the highest versus non- or lowest and increment of daily cup of green tea consumption levels were combined based on fixed- or random-effects models. STATA 11.0 (Stata Corporation, College Station, TX, USA) software was used for statistical analysis.

RESULTS

Nine prospective cohort articles involving 465,274 participants and 3694 cases of liver cancer from China, Japan, and Singapore were included. The summary relative risk (RR) indicated a significant association between the highest green tea consumption and reduced risk for liver cancer (summary RR, 0.88; 95% confidence interval [CI], 0.81-0.97). However, no statistically significant association was observed when analyzing daily consumption of one cup (summary RR, 0.97; 95% CI, 0.95-1.00). When stratified by sex, the protective effect of green tea consumption on risk for liver cancer was observed only in the group of women (summary RR, 0.78; 95% CI, 0.64-0.96), but not in men (summary RR, 0.89; 95% CI, 0.79-1.00).

CONCLUSIONS

The present analysis indicated the preventive effects of green tea intake on the risk for liver cancer in female Asian populations. However, additional studies are needed to make a convincing case for this association.

Authors+Show Affiliations

Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. Electronic address: Zouxiaoping795@hotmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

26412579

Citation

Huang, Ya-Qing, et al. "Green Tea and Liver Cancer Risk: a Meta-analysis of Prospective Cohort Studies in Asian Populations." Nutrition (Burbank, Los Angeles County, Calif.), vol. 32, no. 1, 2016, pp. 3-8.
Huang YQ, Lu X, Min H, et al. Green tea and liver cancer risk: A meta-analysis of prospective cohort studies in Asian populations. Nutrition. 2016;32(1):3-8.
Huang, Y. Q., Lu, X., Min, H., Wu, Q. Q., Shi, X. T., Bian, K. Q., & Zou, X. P. (2016). Green tea and liver cancer risk: A meta-analysis of prospective cohort studies in Asian populations. Nutrition (Burbank, Los Angeles County, Calif.), 32(1), pp. 3-8. doi:10.1016/j.nut.2015.05.021.
Huang YQ, et al. Green Tea and Liver Cancer Risk: a Meta-analysis of Prospective Cohort Studies in Asian Populations. Nutrition. 2016;32(1):3-8. PubMed PMID: 26412579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea and liver cancer risk: A meta-analysis of prospective cohort studies in Asian populations. AU - Huang,Ya-Qing, AU - Lu,Xin, AU - Min,Han, AU - Wu,Qian-Qian, AU - Shi,Xiao-Ting, AU - Bian,Kang-Qi, AU - Zou,Xiao-Ping, Y1 - 2015/07/02/ PY - 2015/02/09/received PY - 2015/05/13/revised PY - 2015/05/20/accepted PY - 2015/9/29/entrez PY - 2015/9/29/pubmed PY - 2016/9/7/medline KW - Asian populations KW - Cohort studies KW - Green tea KW - Liver cancer KW - Meta-analysis SP - 3 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 32 IS - 1 N2 - OBJECTIVES: The aim of this meta-analysis was to investigate whether an association existed between green tea consumption and the risk for liver cancer in prospective cohort studies in Asian populations. METHODS: Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science, and the Chinese Bio-medicine Database published before April 2015. Study-specific risk estimates for the highest versus non- or lowest and increment of daily cup of green tea consumption levels were combined based on fixed- or random-effects models. STATA 11.0 (Stata Corporation, College Station, TX, USA) software was used for statistical analysis. RESULTS: Nine prospective cohort articles involving 465,274 participants and 3694 cases of liver cancer from China, Japan, and Singapore were included. The summary relative risk (RR) indicated a significant association between the highest green tea consumption and reduced risk for liver cancer (summary RR, 0.88; 95% confidence interval [CI], 0.81-0.97). However, no statistically significant association was observed when analyzing daily consumption of one cup (summary RR, 0.97; 95% CI, 0.95-1.00). When stratified by sex, the protective effect of green tea consumption on risk for liver cancer was observed only in the group of women (summary RR, 0.78; 95% CI, 0.64-0.96), but not in men (summary RR, 0.89; 95% CI, 0.79-1.00). CONCLUSIONS: The present analysis indicated the preventive effects of green tea intake on the risk for liver cancer in female Asian populations. However, additional studies are needed to make a convincing case for this association. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/26412579/Green_tea_and_liver_cancer_risk:_A_meta_analysis_of_prospective_cohort_studies_in_Asian_populations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(15)00237-3 DB - PRIME DP - Unbound Medicine ER -