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Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals.
Neuropsychologia 2015; 78:10-7N

Abstract

The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65-90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.

Authors+Show Affiliations

CEDAR, Center for Demographic and Aging Research, Umeå University, S-901 87 Umeå, Sweden; UFBI, Umeå centre for Functional Brain Imaging, Umeå University, Sweden. Electronic address: cj.boraxbekk@umu.se.National Ageing Research Institute, Parkville, Victoria, Australia; Department of Psychiatry, University of Melbourne, Victoria, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Mathematics and Statistics, Murdoch University, WA, Australia.Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, UNSW, Sydney, NSW, Australia.Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, UNSW, Sydney, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Department of Developmental Disability Neuropsychiatry, UNSW Australia, Sydney, NSW, Australia.QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Department of Developmental Disability Neuropsychiatry, UNSW Australia, Sydney, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Dementia Collaborative Research Centre, UNSW Australia, Sydney, NSW, Australia.Centre for Healthy Brain Ageing, UNSW Australia, Sydney, NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.National Ageing Research Institute, Parkville, Victoria, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

26415670

Citation

Boraxbekk, C J., et al. "Investigating the Influence of KIBRA and CLSTN2 Genetic Polymorphisms On Cross-sectional and Longitudinal Measures of Memory Performance and Hippocampal Volume in Older Individuals." Neuropsychologia, vol. 78, 2015, pp. 10-7.
Boraxbekk CJ, Ames D, Kochan NA, et al. Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. Neuropsychologia. 2015;78:10-7.
Boraxbekk, C. J., Ames, D., Kochan, N. A., Lee, T., Thalamuthu, A., Wen, W., ... Mather, K. A. (2015). Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. Neuropsychologia, 78, pp. 10-7. doi:10.1016/j.neuropsychologia.2015.09.031.
Boraxbekk CJ, et al. Investigating the Influence of KIBRA and CLSTN2 Genetic Polymorphisms On Cross-sectional and Longitudinal Measures of Memory Performance and Hippocampal Volume in Older Individuals. Neuropsychologia. 2015;78:10-7. PubMed PMID: 26415670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. AU - Boraxbekk,C J, AU - Ames,David, AU - Kochan,Nicole A, AU - Lee,Teresa, AU - Thalamuthu,Anbupalam, AU - Wen,Wei, AU - Armstrong,Nicola J, AU - Kwok,John B J, AU - Schofield,Peter R, AU - Reppermund,Simone, AU - Wright,Margaret J, AU - Trollor,Julian N, AU - Brodaty,Henry, AU - Sachdev,Perminder, AU - Mather,Karen A, Y1 - 2015/09/28/ PY - 2015/05/22/received PY - 2015/09/23/revised PY - 2015/09/25/accepted PY - 2015/9/30/entrez PY - 2015/9/30/pubmed PY - 2016/8/5/medline KW - CLSTN2 KW - Episodic memory KW - Gene–gene interactions KW - Hippocampus KW - KIBRA SP - 10 EP - 7 JF - Neuropsychologia JO - Neuropsychologia VL - 78 N2 - The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65-90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults. SN - 1873-3514 UR - https://www.unboundmedicine.com/medline/citation/26415670/Investigating_the_influence_of_KIBRA_and_CLSTN2_genetic_polymorphisms_on_cross_sectional_and_longitudinal_measures_of_memory_performance_and_hippocampal_volume_in_older_individuals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(15)30174-3 DB - PRIME DP - Unbound Medicine ER -