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TriGlycerides and high-density lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the chinese obese children: a cross section study.
BMC Pediatr. 2015 Sep 28; 15:138.BPed

Abstract

BACKGROUND

Metabolic Syndrome (MS) is prevalant in China, especially according to the pediatric obesity group. Based on the MS-CHN2012 definition for Chinese children and adolescents the need to explore and establish a convienent MS screening become imminent. This study aims to investigate the optimal cut-off values, compare the accuracy for the (TriGlycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C)) (TG/HDL-C) ratio and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) indexs to identify Metabolic Syndrome in obese pediatric population in China.

METHOD

A total sample of 976 children (female 286 male 690, BMI > = 95 percentile) aged from 6-16 years underwent a medical assessment including a physical examination and investigations of total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, insulin, glucose, and oral glucose tolerance test to identify the components of Metabolic Syndrome. The validity and accuracy between TG/HDL-C ratio and HOMA-IR were compared by Receiver Operating Characteristics analysis (ROC).

RESULT

TG/HDL-C ratio achieved a larger ROC Area under Curve (AUC = 0.843) than HOMA-IR indexes (0.640, 0.625 for HOMA1-IR, HOMA2-IR respectively) to screen for Metabolic Syndrome. The cut-off values for MS were: TG/HDL-C ratio > 1.25 (sensitivity: 80%; specificity: 75%), HOMA1-IR > 4.59 (sensitivity: 58.7%; specificity: 65.5%) and HOMA2-IR > 2.76 (sensitivity: 53.2%; specificity: 69.5%). The results kept robust after stratified by gender, age group and pubertal stage.

DISCUSSION

TG/HDL-C ratio was a better indicator than the HOMA-IR to screen for a positive diagnosis for MS. Furthermore, the TG/HDL-C ratio was superior to the HOMA-IR indexes even after the control of possible confusions from the gender, age group and puberty stage.

CONCLUSION

TG/HDL-C ratio proved a better index than HOMA-IR in screening for MS in obese children and adolescents. TG/HDL-C ratio has a discriminatory power in detecting potential MS in the Chinese obese pediatric population.

Authors+Show Affiliations

Biostatistics Unit of the Children's Hospital, Zhejiang University, School of Medicine, Hangzhou, 310003, China. LIANGJIANFENG@ZJU.EDU.CN.Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. fjf68@qq.com.Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. jiangyoujun888@163.com.Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. dgpxlx@163.com.Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. wangxiumin1019@126.com.Endocrinology Department of the Children's Hospital, Zhejiang University, School of Medicine, 57 Zhugan Avenue, Hangzhou, 310003, China. wuwei120@sina.com.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26416207

Citation

Liang, Jianfeng, et al. "TriGlycerides and High-density Lipoprotein Cholesterol Ratio Compared With Homeostasis Model Assessment Insulin Resistance Indexes in Screening for Metabolic Syndrome in the Chinese Obese Children: a Cross Section Study." BMC Pediatrics, vol. 15, 2015, p. 138.
Liang J, Fu J, Jiang Y, et al. TriGlycerides and high-density lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the chinese obese children: a cross section study. BMC Pediatr. 2015;15:138.
Liang, J., Fu, J., Jiang, Y., Dong, G., Wang, X., & Wu, W. (2015). TriGlycerides and high-density lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the chinese obese children: a cross section study. BMC Pediatrics, 15, 138. https://doi.org/10.1186/s12887-015-0456-y
Liang J, et al. TriGlycerides and High-density Lipoprotein Cholesterol Ratio Compared With Homeostasis Model Assessment Insulin Resistance Indexes in Screening for Metabolic Syndrome in the Chinese Obese Children: a Cross Section Study. BMC Pediatr. 2015 Sep 28;15:138. PubMed PMID: 26416207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TriGlycerides and high-density lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the chinese obese children: a cross section study. AU - Liang,Jianfeng, AU - Fu,Junfen, AU - Jiang,Youyun, AU - Dong,Guanping, AU - Wang,Xiumin, AU - Wu,Wei, Y1 - 2015/09/28/ PY - 2014/10/01/received PY - 2015/09/14/accepted PY - 2015/9/30/entrez PY - 2015/9/30/pubmed PY - 2016/5/10/medline SP - 138 EP - 138 JF - BMC pediatrics JO - BMC Pediatr VL - 15 N2 - BACKGROUND: Metabolic Syndrome (MS) is prevalant in China, especially according to the pediatric obesity group. Based on the MS-CHN2012 definition for Chinese children and adolescents the need to explore and establish a convienent MS screening become imminent. This study aims to investigate the optimal cut-off values, compare the accuracy for the (TriGlycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C)) (TG/HDL-C) ratio and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) indexs to identify Metabolic Syndrome in obese pediatric population in China. METHOD: A total sample of 976 children (female 286 male 690, BMI > = 95 percentile) aged from 6-16 years underwent a medical assessment including a physical examination and investigations of total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, insulin, glucose, and oral glucose tolerance test to identify the components of Metabolic Syndrome. The validity and accuracy between TG/HDL-C ratio and HOMA-IR were compared by Receiver Operating Characteristics analysis (ROC). RESULT: TG/HDL-C ratio achieved a larger ROC Area under Curve (AUC = 0.843) than HOMA-IR indexes (0.640, 0.625 for HOMA1-IR, HOMA2-IR respectively) to screen for Metabolic Syndrome. The cut-off values for MS were: TG/HDL-C ratio > 1.25 (sensitivity: 80%; specificity: 75%), HOMA1-IR > 4.59 (sensitivity: 58.7%; specificity: 65.5%) and HOMA2-IR > 2.76 (sensitivity: 53.2%; specificity: 69.5%). The results kept robust after stratified by gender, age group and pubertal stage. DISCUSSION: TG/HDL-C ratio was a better indicator than the HOMA-IR to screen for a positive diagnosis for MS. Furthermore, the TG/HDL-C ratio was superior to the HOMA-IR indexes even after the control of possible confusions from the gender, age group and puberty stage. CONCLUSION: TG/HDL-C ratio proved a better index than HOMA-IR in screening for MS in obese children and adolescents. TG/HDL-C ratio has a discriminatory power in detecting potential MS in the Chinese obese pediatric population. SN - 1471-2431 UR - https://www.unboundmedicine.com/medline/citation/26416207/TriGlycerides_and_high_density_lipoprotein_cholesterol_ratio_compared_with_homeostasis_model_assessment_insulin_resistance_indexes_in_screening_for_metabolic_syndrome_in_the_chinese_obese_children:_a_cross_section_study_ L2 - https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-015-0456-y DB - PRIME DP - Unbound Medicine ER -