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High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome.
Gut 2016; 65(11):1812-1821Gut

Abstract

OBJECTIVES

Habitual diet plays a major role in shaping the composition of the gut microbiota, and also determines the repertoire of microbial metabolites that can influence the host. The typical Western diet corresponds to that of an omnivore; however, the Mediterranean diet (MD), common in the Western Mediterranean culture, is to date a nutritionally recommended dietary pattern that includes high-level consumption of cereals, fruit, vegetables and legumes. To investigate the potential benefits of the MD in this cross-sectional survey, we assessed the gut microbiota and metabolome in a cohort of Italian individuals in relation to their habitual diets.

DESIGN AND RESULTS

We retrieved daily dietary information and assessed gut microbiota and metabolome in 153 individuals habitually following omnivore, vegetarian or vegan diets. The majority of vegan and vegetarian subjects and 30% of omnivore subjects had a high adherence to the MD. We were able to stratify individuals according to both diet type and adherence to the MD on the basis of their dietary patterns and associated microbiota. We detected significant associations between consumption of vegetable-based diets and increased levels of faecal short-chain fatty acids, Prevotella and some fibre-degrading Firmicutes, whose role in human gut warrants further research. Conversely, we detected higher urinary trimethylamine oxide levels in individuals with lower adherence to the MD.

CONCLUSIONS

High-level consumption of plant foodstuffs consistent with an MD is associated with beneficial microbiome-related metabolomic profiles in subjects ostensibly consuming a Western diet.

TRIAL REGISTRATION NUMBER

This study was registered at clinical trials.gov as NCT02118857.

Authors+Show Affiliations

Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Via Università 100, Portici, Italy.Department of Food Science, University of Parma, Parco Area delle Scienze 48/A, Parma, Italy.Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, viale Fanin 44, Bologna, Italy. Inter-Departmental Centre for Industrial Agri-Food Research, Alma Mater Studiorum University of Bologna, Piazza Goidanich 60 Cesena, Bologna, Italy.Department of Microbiology, University College Cork, Cork, Ireland. Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Via Università 100, Portici, Italy.Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, viale Fanin 44, Bologna, Italy. Inter-Departmental Centre for Industrial Agri-Food Research, Alma Mater Studiorum University of Bologna, Piazza Goidanich 60 Cesena, Bologna, Italy.Inter-Departmental Centre for Industrial Agri-Food Research, Alma Mater Studiorum University of Bologna, Piazza Goidanich 60 Cesena, Bologna, Italy.Department of Soil, Plant and Food Science, University of Bari Aldo Moro, Bari, Italy.Department of Agricultural, Forest and Food Science, University of Turin, Grugliasco, Italy.Department of Food Science, University of Parma, Parco Area delle Scienze 48/A, Parma, Italy.Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, Bologna, Italy.Department of Agricultural, Forest and Food Science, University of Turin, Grugliasco, Italy.Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, Bologna, Italy.Department of Food Science, University of Parma, Parco Area delle Scienze 48/A, Parma, Italy.Department of Soil, Plant and Food Science, University of Bari Aldo Moro, Bari, Italy.Department of Microbiology, University College Cork, Cork, Ireland. Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Via Università 100, Portici, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26416813

Citation

De Filippis, Francesca, et al. "High-level Adherence to a Mediterranean Diet Beneficially Impacts the Gut Microbiota and Associated Metabolome." Gut, vol. 65, no. 11, 2016, pp. 1812-1821.
De Filippis F, Pellegrini N, Vannini L, et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut. 2016;65(11):1812-1821.
De Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., ... Ercolini, D. (2016). High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut, 65(11), pp. 1812-1821. doi:10.1136/gutjnl-2015-309957.
De Filippis F, et al. High-level Adherence to a Mediterranean Diet Beneficially Impacts the Gut Microbiota and Associated Metabolome. Gut. 2016;65(11):1812-1821. PubMed PMID: 26416813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. AU - De Filippis,Francesca, AU - Pellegrini,Nicoletta, AU - Vannini,Lucia, AU - Jeffery,Ian B, AU - La Storia,Antonietta, AU - Laghi,Luca, AU - Serrazanetti,Diana I, AU - Di Cagno,Raffaella, AU - Ferrocino,Ilario, AU - Lazzi,Camilla, AU - Turroni,Silvia, AU - Cocolin,Luca, AU - Brigidi,Patrizia, AU - Neviani,Erasmo, AU - Gobbetti,Marco, AU - O'Toole,Paul W, AU - Ercolini,Danilo, Y1 - 2015/09/28/ PY - 2015/05/11/received PY - 2015/07/15/revised PY - 2015/08/05/accepted PY - 2015/9/30/pubmed PY - 2017/6/21/medline PY - 2015/9/30/entrez KW - DIET KW - DIETARY FIBRE KW - ENTERIC BACTERIAL MICROFLORA KW - INTESTINAL BACTERIA KW - SHORT CHAIN FATTY ACIDS SP - 1812 EP - 1821 JF - Gut JO - Gut VL - 65 IS - 11 N2 - OBJECTIVES: Habitual diet plays a major role in shaping the composition of the gut microbiota, and also determines the repertoire of microbial metabolites that can influence the host. The typical Western diet corresponds to that of an omnivore; however, the Mediterranean diet (MD), common in the Western Mediterranean culture, is to date a nutritionally recommended dietary pattern that includes high-level consumption of cereals, fruit, vegetables and legumes. To investigate the potential benefits of the MD in this cross-sectional survey, we assessed the gut microbiota and metabolome in a cohort of Italian individuals in relation to their habitual diets. DESIGN AND RESULTS: We retrieved daily dietary information and assessed gut microbiota and metabolome in 153 individuals habitually following omnivore, vegetarian or vegan diets. The majority of vegan and vegetarian subjects and 30% of omnivore subjects had a high adherence to the MD. We were able to stratify individuals according to both diet type and adherence to the MD on the basis of their dietary patterns and associated microbiota. We detected significant associations between consumption of vegetable-based diets and increased levels of faecal short-chain fatty acids, Prevotella and some fibre-degrading Firmicutes, whose role in human gut warrants further research. Conversely, we detected higher urinary trimethylamine oxide levels in individuals with lower adherence to the MD. CONCLUSIONS: High-level consumption of plant foodstuffs consistent with an MD is associated with beneficial microbiome-related metabolomic profiles in subjects ostensibly consuming a Western diet. TRIAL REGISTRATION NUMBER: This study was registered at clinical trials.gov as NCT02118857. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/26416813/High_level_adherence_to_a_Mediterranean_diet_beneficially_impacts_the_gut_microbiota_and_associated_metabolome_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=26416813 DB - PRIME DP - Unbound Medicine ER -