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Association of the Number of Years Since Menopause with Metabolic Syndrome and Insulin Resistance in Chinese Urban Women.
J Womens Health (Larchmt). 2015 Oct; 24(10):843-8.JW

Abstract

BACKGROUND

This study aimed to assess the prevalence of metabolic syndrome (MetS) and the association of years since menopause with MetS and Insulin Resistance (IR) in Chinese women.

METHOD

A total of 4436 Chinese subjects aged 40-80 years participated in the study; 790 were premenopausal women, and 3646 were postmenopausal women. IR was arbitrarily defined as a homeostasis model assessment-IR index (HOMA-IR) value above the 75th percentile of normal glucose tolerance (NGT). MetS was defined according to the International Diabetes Federation consensus definition. To test whether there was an association between the number of years since menopause and MetS, multivariate logistic analysis was conducted. Premenopausal women were used as a comparison group in regression analyses.

RESULTS

After adjustment for age, body mass index (BMI), and γ-glutamyltransferase (GGT), more years since menopause was highly associated with an increased risk of MetS (p for trend <0.05) ; the number of years since menopause was not correlated with fasting insulin and HOMA-IR. Postmenopausal women with 10 to 14 years since menopause had the highest risk (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.52-2.89, p < .05) of MetS, high triglycerides (TG; OR, 1.80; 95% CI, 1.34-2.42, p < .05) and high glucose (OR, 1.52; 95% CI, 1.14-2.05, p < .05) and low high-density lipoprotein cholesterol (HDL-C; OR, 1.38; 95% CI, 1.18-2.32, p < .05). Postmenopausal women with more than 15 years since menopause had the highest risk of abdominal obesity (OR, 1.69; 95% CI, 1.05-2.71, p < .05).

CONCLUSION

In China, more years since menopause was highly associated with an increased risk of MetS. Menopausal history may help identify women with increased risk of developing MetS.

Authors+Show Affiliations

1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .7 Department of Poisoning and Occupational Diseases, Qilu Hospital of Shandong University , Jinan, China .2 Shantui Community Health Center , Jining, China .3 Department of Endocrinology, Second People's Hospital of Jining , Jining, China .4 Lukang Hospital of Jining , Jining, China .5 China National Heavy Duty Truck Group Corporation Hospital , Jinan, China .1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .6 Department of Endocrinology, The Second Hospital of Shandong University , Jinan, Shandong, China .1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26418517

Citation

Yan, Fei, et al. "Association of the Number of Years Since Menopause With Metabolic Syndrome and Insulin Resistance in Chinese Urban Women." Journal of Women's Health (2002), vol. 24, no. 10, 2015, pp. 843-8.
Yan F, Liu J, Zhao X, et al. Association of the Number of Years Since Menopause with Metabolic Syndrome and Insulin Resistance in Chinese Urban Women. J Womens Health (Larchmt). 2015;24(10):843-8.
Yan, F., Liu, J., Zhao, X., Hu, X., Wang, S., Ma, Z., Liang, K., Song, J., Wang, C., Hou, X., Chen, S., & Chen, L. (2015). Association of the Number of Years Since Menopause with Metabolic Syndrome and Insulin Resistance in Chinese Urban Women. Journal of Women's Health (2002), 24(10), 843-8. https://doi.org/10.1089/jwh.2014.5183
Yan F, et al. Association of the Number of Years Since Menopause With Metabolic Syndrome and Insulin Resistance in Chinese Urban Women. J Womens Health (Larchmt). 2015;24(10):843-8. PubMed PMID: 26418517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the Number of Years Since Menopause with Metabolic Syndrome and Insulin Resistance in Chinese Urban Women. AU - Yan,Fei, AU - Liu,Jidong, AU - Zhao,Xiangmin, AU - Hu,Xiuping, AU - Wang,Shaoyuan, AU - Ma,Zeqiang, AU - Liang,Kai, AU - Song,Jun, AU - Wang,Chuan, AU - Hou,Xinguo, AU - Chen,Shihong, AU - Chen,Li, Y1 - 2015/09/29/ PY - 2015/9/30/entrez PY - 2015/9/30/pubmed PY - 2016/7/30/medline SP - 843 EP - 8 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 24 IS - 10 N2 - BACKGROUND: This study aimed to assess the prevalence of metabolic syndrome (MetS) and the association of years since menopause with MetS and Insulin Resistance (IR) in Chinese women. METHOD: A total of 4436 Chinese subjects aged 40-80 years participated in the study; 790 were premenopausal women, and 3646 were postmenopausal women. IR was arbitrarily defined as a homeostasis model assessment-IR index (HOMA-IR) value above the 75th percentile of normal glucose tolerance (NGT). MetS was defined according to the International Diabetes Federation consensus definition. To test whether there was an association between the number of years since menopause and MetS, multivariate logistic analysis was conducted. Premenopausal women were used as a comparison group in regression analyses. RESULTS: After adjustment for age, body mass index (BMI), and γ-glutamyltransferase (GGT), more years since menopause was highly associated with an increased risk of MetS (p for trend <0.05) ; the number of years since menopause was not correlated with fasting insulin and HOMA-IR. Postmenopausal women with 10 to 14 years since menopause had the highest risk (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.52-2.89, p < .05) of MetS, high triglycerides (TG; OR, 1.80; 95% CI, 1.34-2.42, p < .05) and high glucose (OR, 1.52; 95% CI, 1.14-2.05, p < .05) and low high-density lipoprotein cholesterol (HDL-C; OR, 1.38; 95% CI, 1.18-2.32, p < .05). Postmenopausal women with more than 15 years since menopause had the highest risk of abdominal obesity (OR, 1.69; 95% CI, 1.05-2.71, p < .05). CONCLUSION: In China, more years since menopause was highly associated with an increased risk of MetS. Menopausal history may help identify women with increased risk of developing MetS. SN - 1931-843X UR - https://www.unboundmedicine.com/medline/citation/26418517/Association_of_the_Number_of_Years_Since_Menopause_with_Metabolic_Syndrome_and_Insulin_Resistance_in_Chinese_Urban_Women_ L2 - https://www.liebertpub.com/doi/10.1089/jwh.2014.5183?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -