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PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.
Gut Liver. 2016 May 23; 10(3):456-63.GL

Abstract

BACKGROUND/AIMS

The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients.

METHODS

We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software.

RESULTS

The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG OR, 2.29; 95% CI, 1.57 to 3.35; p<0.05) but not Asian populations. In Caucasians, liver steatosis was also more severe in CHC patients with rs738409 GG (versus CC+CG; OR, 4.33; 95% CI, 2.59 to 7.22; p<0.05). The sensitivity analysis indicated the results of this meta-analysis were stable and no publication bias was detected.

CONCLUSIONS

PNPLA3 rs738409 (C>G) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.Department of Infectious Diseases, The Ninth People's Hospital of Chongqing, Chongqing, China.Institute of Life Sciences, Chongqing Medical University, Chongqing, China.Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

26419236

Citation

Fan, Jia-Hao, et al. "PNPLA3 Rs738409 Polymorphism Associated With Hepatic Steatosis and Advanced Fibrosis in Patients With Chronic Hepatitis C Virus: a Meta-Analysis." Gut and Liver, vol. 10, no. 3, 2016, pp. 456-63.
Fan JH, Xiang MQ, Li QL, et al. PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis. Gut Liver. 2016;10(3):456-63.
Fan, J. H., Xiang, M. Q., Li, Q. L., Shi, H. T., & Guo, J. J. (2016). PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis. Gut and Liver, 10(3), 456-63. https://doi.org/10.5009/gnl15261
Fan JH, et al. PNPLA3 Rs738409 Polymorphism Associated With Hepatic Steatosis and Advanced Fibrosis in Patients With Chronic Hepatitis C Virus: a Meta-Analysis. Gut Liver. 2016 May 23;10(3):456-63. PubMed PMID: 26419236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis. AU - Fan,Jia-Hao, AU - Xiang,Ming-Que, AU - Li,Qing-Ling, AU - Shi,Hong-Tao, AU - Guo,Jin-Jun, PY - 2015/10/1/entrez PY - 2015/10/1/pubmed PY - 2017/6/24/medline KW - Advanced liver fibrosis KW - Fatty liver KW - Hepatitis C, chronic KW - Meta-analysis KW - Patatin-like phospholipase domain containing protein 3 rs738409 SP - 456 EP - 63 JF - Gut and liver JO - Gut Liver VL - 10 IS - 3 N2 - BACKGROUND/AIMS: The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients. METHODS: We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software. RESULTS: The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG OR, 2.29; 95% CI, 1.57 to 3.35; p<0.05) but not Asian populations. In Caucasians, liver steatosis was also more severe in CHC patients with rs738409 GG (versus CC+CG; OR, 4.33; 95% CI, 2.59 to 7.22; p<0.05). The sensitivity analysis indicated the results of this meta-analysis were stable and no publication bias was detected. CONCLUSIONS: PNPLA3 rs738409 (C>G) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations. SN - 2005-1212 UR - https://www.unboundmedicine.com/medline/citation/26419236/PNPLA3_rs738409_Polymorphism_Associated_with_Hepatic_Steatosis_and_Advanced_Fibrosis_in_Patients_with_Chronic_Hepatitis_C_Virus:_A_Meta_Analysis_ L2 - http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15261 DB - PRIME DP - Unbound Medicine ER -