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Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex.
Exp Brain Res. 2016 Jan; 234(1):185-95.EB

Abstract

Stopping outright (reactive inhibition) and slowing down (proactive inhibition) are types of response inhibition which have mainly been investigated in the manual effector system. This study compared reactive inhibition across manual and vocal effector systems, examined the effects of excitatory anodal transcranial direct current stimulation (anodal tDCS) over the right prefrontal cortex (right-PFC) and looked at the relationship between reactive and proactive inhibition. We hypothesised (1) that vocal reactive inhibition would be less effective than manual reactive inhibition as evidenced by longer stop signal reaction times; (2) that anodal tDCS would enhance both vocal and manual reactive inhibitions and (3) that proactive and reactive inhibitions would be positively related. We tested 14 participants over two sessions (one session with anodal tDCS and one session with sham stimulation) and applied stimulation protocol in the middle of the session, i.e. only during the second of three phases. We used a stop signal task across two stop conditions: relevant and irrelevant stop conditions in which stopping was required or ignored, respectively. We found that reactive inhibition was faster during and immediately after anodal tDCS relative to sham. We also found that greater level of proactive inhibition enhanced reactive inhibition (indexed by shorter stop signal reaction times). These results support the hypothesis that the right-PFC is part of a core network for reactive inhibition and supports previous contention that proactive inhibition is possibly modulated via preactivating the reactive inhibition network.

Authors+Show Affiliations

Department of Cognitive Science, Australian Research Council Centre of Excellence in Cognition and Its Disorders (CCD), Macquarie University, North Ryde, NSW, 2109, Australia. leidy-janeth.castro-meneses@students.mq.edu.au. Department of Cognitive Science, Perception in Action Research Centre (PARC), Macquarie University, North Ryde, NSW, 2109, Australia. leidy-janeth.castro-meneses@students.mq.edu.au.Department of Cognitive Science, Australian Research Council Centre of Excellence in Cognition and Its Disorders (CCD), Macquarie University, North Ryde, NSW, 2109, Australia.Department of Cognitive Science, Australian Research Council Centre of Excellence in Cognition and Its Disorders (CCD), Macquarie University, North Ryde, NSW, 2109, Australia. Department of Cognitive Science, Perception in Action Research Centre (PARC), Macquarie University, North Ryde, NSW, 2109, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26419662

Citation

Castro-Meneses, Leidy J., et al. "Vocal Response Inhibition Is Enhanced By Anodal tDCS Over the Right Prefrontal Cortex." Experimental Brain Research, vol. 234, no. 1, 2016, pp. 185-95.
Castro-Meneses LJ, Johnson BW, Sowman PF. Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex. Exp Brain Res. 2016;234(1):185-95.
Castro-Meneses, L. J., Johnson, B. W., & Sowman, P. F. (2016). Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex. Experimental Brain Research, 234(1), 185-95. https://doi.org/10.1007/s00221-015-4452-0
Castro-Meneses LJ, Johnson BW, Sowman PF. Vocal Response Inhibition Is Enhanced By Anodal tDCS Over the Right Prefrontal Cortex. Exp Brain Res. 2016;234(1):185-95. PubMed PMID: 26419662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex. AU - Castro-Meneses,Leidy J, AU - Johnson,Blake W, AU - Sowman,Paul F, Y1 - 2015/09/29/ PY - 2015/06/03/received PY - 2015/09/18/accepted PY - 2015/10/1/entrez PY - 2015/10/1/pubmed PY - 2016/11/1/medline KW - Anodal tDCS KW - Reactive inhibition and proactive inhibition KW - Response inhibition KW - Stop signal task KW - Vocal inhibition SP - 185 EP - 95 JF - Experimental brain research JO - Exp Brain Res VL - 234 IS - 1 N2 - Stopping outright (reactive inhibition) and slowing down (proactive inhibition) are types of response inhibition which have mainly been investigated in the manual effector system. This study compared reactive inhibition across manual and vocal effector systems, examined the effects of excitatory anodal transcranial direct current stimulation (anodal tDCS) over the right prefrontal cortex (right-PFC) and looked at the relationship between reactive and proactive inhibition. We hypothesised (1) that vocal reactive inhibition would be less effective than manual reactive inhibition as evidenced by longer stop signal reaction times; (2) that anodal tDCS would enhance both vocal and manual reactive inhibitions and (3) that proactive and reactive inhibitions would be positively related. We tested 14 participants over two sessions (one session with anodal tDCS and one session with sham stimulation) and applied stimulation protocol in the middle of the session, i.e. only during the second of three phases. We used a stop signal task across two stop conditions: relevant and irrelevant stop conditions in which stopping was required or ignored, respectively. We found that reactive inhibition was faster during and immediately after anodal tDCS relative to sham. We also found that greater level of proactive inhibition enhanced reactive inhibition (indexed by shorter stop signal reaction times). These results support the hypothesis that the right-PFC is part of a core network for reactive inhibition and supports previous contention that proactive inhibition is possibly modulated via preactivating the reactive inhibition network. SN - 1432-1106 UR - https://www.unboundmedicine.com/medline/citation/26419662/Vocal_response_inhibition_is_enhanced_by_anodal_tDCS_over_the_right_prefrontal_cortex_ L2 - https://dx.doi.org/10.1007/s00221-015-4452-0 DB - PRIME DP - Unbound Medicine ER -