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One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization.
J Org Chem. 2015 Oct 16; 80(20):9973-9.JO

Abstract

Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then intramolecular Friedel-Crafts alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields.

Authors+Show Affiliations

Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26419666

Citation

Zhu, Yu-Qin, and Lin Dong. "One-Pot Synthesis of Polysubstituted Spirofluorene-Indene Via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization." The Journal of Organic Chemistry, vol. 80, no. 20, 2015, pp. 9973-9.
Zhu YQ, Dong L. One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization. J Org Chem. 2015;80(20):9973-9.
Zhu, Y. Q., & Dong, L. (2015). One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization. The Journal of Organic Chemistry, 80(20), 9973-9. https://doi.org/10.1021/acs.joc.5b01517
Zhu YQ, Dong L. One-Pot Synthesis of Polysubstituted Spirofluorene-Indene Via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization. J Org Chem. 2015 Oct 16;80(20):9973-9. PubMed PMID: 26419666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization. AU - Zhu,Yu-Qin, AU - Dong,Lin, Y1 - 2015/10/07/ PY - 2015/10/1/entrez PY - 2015/10/1/pubmed PY - 2016/3/8/medline SP - 9973 EP - 9 JF - The Journal of organic chemistry JO - J Org Chem VL - 80 IS - 20 N2 - Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then intramolecular Friedel-Crafts alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields. SN - 1520-6904 UR - https://www.unboundmedicine.com/medline/citation/26419666/One_Pot_Synthesis_of_Polysubstituted_Spirofluorene_Indene_via_Ru_II__Catalyzed_[3_+_2]_Annulation_and_Intramolecular_Friedel_Crafts_Cyclization_ DB - PRIME DP - Unbound Medicine ER -