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[Meta-analysis of clinical trials of folic acid, vitamin B12 and B6 supplementation on plasma homocysteine level and risk of cardiovascular disease].

Abstract

OBJECTIVE

To evaluate the effects of folic acid, vitamin B(6) and B(12) supplementation on plasma homocysteine level and risk of cardiovascular disease.

METHODS

The databases, including Embase, Pubmed, Ovid, Biosis, China National Knowledge Infra-structure (CNKI), Wanfang Data, VIP Database for Chinese Technical Periodical (VIP), Chinese Biomedical Literature Database (CMB), were searched to identify random control trials between February 1994 to February 2014 on the effect of folic acid, vitamin B(6) and B(12) supplementation on plasma homocysteine level and risk of cardiovascular disease. The screening, data extraction and quality assessment were conducted in accordance with the inclusion and exclusion criteria by two reviewers independently. The software Review Manager 5.2 was used. Funnel plots and Egger's regression test were applied to evaluate the publication bias.

RESULTS

Data from 12 studies including 34 481 patients were analyzed using a fixed-effects model. Funnel plot and Egger's test (P > 0.10) confirmed the absence of publication bias. No statistically significant heterogeneity was detected on testing after excluding the sources of heterogeneity (chi-square test, I < 2 < 50%). Baseline homocysteine levels were similar between the placebo and folic acid, vitamin B(6) and B(12) groups (all P > 0.05). Mean homocysteine levels were significantly lower with folic acid, vitamin B(6) and B(12) therapy compared with placebo during follow-up (all P < 0.05). The pooled relative risks with 95% confidence intervals of outcomes for patients treated with folic acid, vitamin B(6) and B(12) supplementation compared with placebo were 0.98 (0.93-1.03) for cardiovascular event, 0.97 (0.87-1.07) for coronary artery disease, 1.00 (0.92-1.08) for myocardial infarction and 0.92 (0.82-1.03) for cardiovascular death.

CONCLUSIONS

Folic aicd combined with vitamin B(6) and B(12) treatment significantly reduced plasma homocysteine level, but did not affect the risk of cardiovascular disease. Thus, folic acid combined with vitamin B(6) and B(12) should not be recommended as secondary prevention of cardiovascular diseases.

Authors+Show Affiliations

Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China; Email: shenb@enzemed.com.

Pub Type(s)

English Abstract
Journal Article
Meta-Analysis

Language

chi

PubMed ID

26420127

Citation

Li, Jun, et al. "[Meta-analysis of Clinical Trials of Folic Acid, Vitamin B12 and B6 Supplementation On Plasma Homocysteine Level and Risk of Cardiovascular Disease]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 43, no. 6, 2015, pp. 554-61.
Li J, Li B, Qi J, et al. [Meta-analysis of clinical trials of folic acid, vitamin B12 and B6 supplementation on plasma homocysteine level and risk of cardiovascular disease]. Zhonghua Xin Xue Guan Bing Za Zhi. 2015;43(6):554-61.
Li, J., Li, B., Qi, J., & Shen, B. (2015). [Meta-analysis of clinical trials of folic acid, vitamin B12 and B6 supplementation on plasma homocysteine level and risk of cardiovascular disease]. Zhonghua Xin Xue Guan Bing Za Zhi, 43(6), pp. 554-61.
Li J, et al. [Meta-analysis of Clinical Trials of Folic Acid, Vitamin B12 and B6 Supplementation On Plasma Homocysteine Level and Risk of Cardiovascular Disease]. Zhonghua Xin Xue Guan Bing Za Zhi. 2015;43(6):554-61. PubMed PMID: 26420127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Meta-analysis of clinical trials of folic acid, vitamin B12 and B6 supplementation on plasma homocysteine level and risk of cardiovascular disease]. AU - Li,Jun, AU - Li,Bin, AU - Qi,Juanfei, AU - Shen,Bo, PY - 2015/10/1/entrez PY - 2015/10/1/pubmed PY - 2015/12/15/medline SP - 554 EP - 61 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 43 IS - 6 N2 - OBJECTIVE: To evaluate the effects of folic acid, vitamin B(6) and B(12) supplementation on plasma homocysteine level and risk of cardiovascular disease. METHODS: The databases, including Embase, Pubmed, Ovid, Biosis, China National Knowledge Infra-structure (CNKI), Wanfang Data, VIP Database for Chinese Technical Periodical (VIP), Chinese Biomedical Literature Database (CMB), were searched to identify random control trials between February 1994 to February 2014 on the effect of folic acid, vitamin B(6) and B(12) supplementation on plasma homocysteine level and risk of cardiovascular disease. The screening, data extraction and quality assessment were conducted in accordance with the inclusion and exclusion criteria by two reviewers independently. The software Review Manager 5.2 was used. Funnel plots and Egger's regression test were applied to evaluate the publication bias. RESULTS: Data from 12 studies including 34 481 patients were analyzed using a fixed-effects model. Funnel plot and Egger's test (P > 0.10) confirmed the absence of publication bias. No statistically significant heterogeneity was detected on testing after excluding the sources of heterogeneity (chi-square test, I < 2 < 50%). Baseline homocysteine levels were similar between the placebo and folic acid, vitamin B(6) and B(12) groups (all P > 0.05). Mean homocysteine levels were significantly lower with folic acid, vitamin B(6) and B(12) therapy compared with placebo during follow-up (all P < 0.05). The pooled relative risks with 95% confidence intervals of outcomes for patients treated with folic acid, vitamin B(6) and B(12) supplementation compared with placebo were 0.98 (0.93-1.03) for cardiovascular event, 0.97 (0.87-1.07) for coronary artery disease, 1.00 (0.92-1.08) for myocardial infarction and 0.92 (0.82-1.03) for cardiovascular death. CONCLUSIONS: Folic aicd combined with vitamin B(6) and B(12) treatment significantly reduced plasma homocysteine level, but did not affect the risk of cardiovascular disease. Thus, folic acid combined with vitamin B(6) and B(12) should not be recommended as secondary prevention of cardiovascular diseases. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/26420127/[Meta_analysis_of_clinical_trials_of_folic_acid_vitamin_B12_and_B6_supplementation_on_plasma_homocysteine_level_and_risk_of_cardiovascular_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3758&amp;year=2015&amp;vol=43&amp;issue=6&amp;fpage=554 DB - PRIME DP - Unbound Medicine ER -