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Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response.
Br J Nutr 2015; 114(11):1845-51BJ

Abstract

Consumption of high glycaemic index (GI) and glycaemic response (GR) food such as white rice has been implicated in the development of type 2 diabetes. Previous studies have reported the ability of individual amino acids to reduce GR of carbohydrate-rich foods. Because of the bitter flavour of amino acids, they have rarely been used to reduce GR. We now report the use of a palatable, preformed amino acid mixture in the form of essence of chicken. In all, sixteen healthy male Chinese were served 68 or 136 ml amino acid mixture together with rice, or 15 or 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of the meal until 60 min after the consumption of the white rice. Subsequent blood samples were taken at 30-min intervals until 210 min. The co-ingestion of 68 ml of amino acid mixture with white rice produced the best results in reducing the peak blood glucose and GR of white rice without increasing the insulinaemic response. It is postulated that amino acid mixtures prime β-cell insulin secretion and peripheral tissue uptake of glucose. The use of ready-to-drink amino acid mixtures may be a useful strategy for lowering the high-GI rice diets consumed in Asia.

Authors+Show Affiliations

1Clinical Nutrition Research Centre,Singapore Institute for Clinical Sciences,Singapore 117599,Singapore.1Clinical Nutrition Research Centre,Singapore Institute for Clinical Sciences,Singapore 117599,Singapore.1Clinical Nutrition Research Centre,Singapore Institute for Clinical Sciences,Singapore 117599,Singapore.1Clinical Nutrition Research Centre,Singapore Institute for Clinical Sciences,Singapore 117599,Singapore.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26420496

Citation

Soong, Yean Yean, et al. "Effect of Co-ingestion of Amino Acids With Rice On Glycaemic and Insulinaemic Response." The British Journal of Nutrition, vol. 114, no. 11, 2015, pp. 1845-51.
Soong YY, Lim J, Sun L, et al. Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response. Br J Nutr. 2015;114(11):1845-51.
Soong, Y. Y., Lim, J., Sun, L., & Henry, C. J. (2015). Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response. The British Journal of Nutrition, 114(11), pp. 1845-51. doi:10.1017/S0007114515003645.
Soong YY, et al. Effect of Co-ingestion of Amino Acids With Rice On Glycaemic and Insulinaemic Response. Br J Nutr. 2015 Dec 14;114(11):1845-51. PubMed PMID: 26420496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response. AU - Soong,Yean Yean, AU - Lim,Joseph, AU - Sun,Lijuan, AU - Henry,Christiani Jeyakumar, Y1 - 2015/09/30/ PY - 2015/10/1/entrez PY - 2015/10/1/pubmed PY - 2016/2/19/medline KW - Amino acid mixtures KW - EOC essence of chicken KW - Essence of chicken KW - GI glycaemic index KW - GR glycaemic response KW - Glycaemic response KW - IAUC incremental AUC KW - IGI insulinogenic index KW - IR insulinaemic response KW - Insulin response KW - T2D type 2 diabetes KW - White rice SP - 1845 EP - 51 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 114 IS - 11 N2 - Consumption of high glycaemic index (GI) and glycaemic response (GR) food such as white rice has been implicated in the development of type 2 diabetes. Previous studies have reported the ability of individual amino acids to reduce GR of carbohydrate-rich foods. Because of the bitter flavour of amino acids, they have rarely been used to reduce GR. We now report the use of a palatable, preformed amino acid mixture in the form of essence of chicken. In all, sixteen healthy male Chinese were served 68 or 136 ml amino acid mixture together with rice, or 15 or 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of the meal until 60 min after the consumption of the white rice. Subsequent blood samples were taken at 30-min intervals until 210 min. The co-ingestion of 68 ml of amino acid mixture with white rice produced the best results in reducing the peak blood glucose and GR of white rice without increasing the insulinaemic response. It is postulated that amino acid mixtures prime β-cell insulin secretion and peripheral tissue uptake of glucose. The use of ready-to-drink amino acid mixtures may be a useful strategy for lowering the high-GI rice diets consumed in Asia. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26420496/Effect_of_co_ingestion_of_amino_acids_with_rice_on_glycaemic_and_insulinaemic_response_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515003645/type/journal_article DB - PRIME DP - Unbound Medicine ER -