Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII.Bioorg Med Chem. 2015 Oct 15; 23(20):6573-80.BM
Abstract
By using a multi component reaction system (MCR), nitro acridine sulfonamides were obtained from cyclic-1,3-diketones, 4-aminobenzene sulfonamide and aromatic aldehydes. Some novel acridine bis-sulfonamides 6a-l were then synthesized by the reaction between sulfonyl chlorides and the novel amino-acridine sulfonamides 5a and 5b, obtained by reduction of nitro-acridine sulfonamide derivatives 4a and 4b. The newly synthesized compounds were investigated as inhibitors of 4 human carbonic anhydrase isoforms (hCA, EC 4.2.1.1). Several of the compounds showed low micromolar inhibition against the medically relevant isoforms hCA I, II, IX, and XII.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
26422787
Citation
Esirden, İbrahim, et al. "Synthesis of Novel Acridine Bis-sulfonamides With Effective Inhibitory Activity Against the Carbonic Anhydrase Isoforms I, II, IX and XII." Bioorganic & Medicinal Chemistry, vol. 23, no. 20, 2015, pp. 6573-80.
Esirden İ, Ulus R, Aday B, et al. Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII. Bioorg Med Chem. 2015;23(20):6573-80.
Esirden, İ., Ulus, R., Aday, B., Tanç, M., Supuran, C. T., & Kaya, M. (2015). Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry, 23(20), 6573-80. https://doi.org/10.1016/j.bmc.2015.09.022
Esirden İ, et al. Synthesis of Novel Acridine Bis-sulfonamides With Effective Inhibitory Activity Against the Carbonic Anhydrase Isoforms I, II, IX and XII. Bioorg Med Chem. 2015 Oct 15;23(20):6573-80. PubMed PMID: 26422787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII.
AU - Esirden,İbrahim,
AU - Ulus,Ramazan,
AU - Aday,Burak,
AU - Tanç,Muhammet,
AU - Supuran,Claudiu T,
AU - Kaya,Muharrem,
Y1 - 2015/09/15/
PY - 2015/07/20/received
PY - 2015/09/10/revised
PY - 2015/09/14/accepted
PY - 2015/10/1/entrez
PY - 2015/10/1/pubmed
PY - 2016/4/27/medline
KW - Acridine
KW - Carbonic anhydrase
KW - Enzyme inhibition
KW - Isoforms CA I, II, IX and VII
KW - Sulfonamide
SP - 6573
EP - 80
JF - Bioorganic & medicinal chemistry
JO - Bioorg Med Chem
VL - 23
IS - 20
N2 - By using a multi component reaction system (MCR), nitro acridine sulfonamides were obtained from cyclic-1,3-diketones, 4-aminobenzene sulfonamide and aromatic aldehydes. Some novel acridine bis-sulfonamides 6a-l were then synthesized by the reaction between sulfonyl chlorides and the novel amino-acridine sulfonamides 5a and 5b, obtained by reduction of nitro-acridine sulfonamide derivatives 4a and 4b. The newly synthesized compounds were investigated as inhibitors of 4 human carbonic anhydrase isoforms (hCA, EC 4.2.1.1). Several of the compounds showed low micromolar inhibition against the medically relevant isoforms hCA I, II, IX, and XII.
SN - 1464-3391
UR - https://www.unboundmedicine.com/medline/citation/26422787/Synthesis_of_novel_acridine_bis_sulfonamides_with_effective_inhibitory_activity_against_the_carbonic_anhydrase_isoforms_I_II_IX_and_XII_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(15)30047-X
DB - PRIME
DP - Unbound Medicine
ER -