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Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study.

Abstract

BACKGROUND

The prevalence of asthma and allergy has recently risen among children. This increase in prevalence might be related to various factors, particularly diet. The aim of this study is to assess the prevalence and association of asthma and allergic sensitization with dietary factors in the French Six Cities Study.

METHODS

Cross-sectional studies were performed among 7432 schoolchildren aged 9-11 years in Bordeaux, Clermont-Ferrand, Créteil, Marseille, Reims, and Strasbourg. Parental questionnaires, based on the International Study on Asthma and Allergies in Childhood (ISAAC), were used to collect information on allergic diseases and potential exposure factors including a food frequency questionnaire to evaluate dietary habits. Skin prick testing to common allergens for allergic sensitization and bronchial hyper-responsiveness (BHR) testing to exercise were performed. Confounders control was performed with multiple logistic regressions.

RESULTS

Asthma symptoms, asthma and allergic sensitization were more prevalent in boys than in girls and were more prevalent in the South than in the North of France. After adjustment for confounders, fruit juice intake was associated with a low prevalence of lifetime asthma (ORa [95 % CI]; 0.73 [0.56-0.97]), butter intake was positively associated with atopic wheeze (1.48 [1.07-2.05]) and having lunch at the canteen 1-2 times/week compared to never or occasionally was associated with a lower prevalence of past year wheeze (0.71 [0.52-0.96]), lifetime asthma (0.76 [0.60-0.96]) and allergic sensitization (0.80 [0.67-0.95]). Meat intake was inversely related to past year wheeze among atopic children (0.68 [0.50-0.98]) while fast food consumption and butter intake were associated with an increase prevalence of asthma (2.39 [1.47-3.93] and 1.51 [1.17-2.00] respectively). Fish intake was associated with a lower prevalence of asthma among non-atopic children (0.61 [0.43-0.87]. None of the dietary factors was associated with BHR.

CONCLUSIONS

Diet is associated with wheeze, asthma and allergic sensitization but not with BHR in children. These results provide further evidence that adherence to a healthy diet including fruits, meat and fish seems to have a protective effect on asthma and allergy in childhood. However, prospective and experimental studies are needed to provide causal evidence concerning the effect of diet on asthma and atopy.

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  • Authors+Show Affiliations

    ,

    Clinical and Epidemiological Research Laboratory, Lebanese University, Hadath, Lebanon. daniellesaadeh@hotmail.com. INSERM U897, Institut de Santé Publique d'Epidémiologie et de Développement, Laboratoire Santé Travail Environnement, Université de Bordeaux, Bordeaux, France. daniellesaadeh@hotmail.com.

    ,

    Clinical and Epidemiological Research Laboratory, Lebanese University, Hadath, Lebanon. pascalesalameh1@hotmail.com.

    ,

    Hôpital Gabriel Montpied, Clermont-Ferrand, France. dcaillaud@chu-clermontferrand.fr.

    ,

    Hôpital Nord, Marseille, France. denisandre.charpin@ap-hm.fr.

    ,

    Hôpital Civil, Strasbourg, France. frederic.deblay@chru-strasbourg.fr.

    ,

    Hôpital Civil, Strasbourg, France. christine.kopferschmitt@wanadoo.fr.

    ,

    Hôpital Maison Blanche, Reims, France. flavaud@chu-reims.fr.

    ,

    EPAR, UMR-S 1136, Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Universities, Paris, France. Isabella.annesi-maesano@inserm.fr.

    ,

    INSERM U897, Institut de Santé Publique d'Epidémiologie et de Développement, Laboratoire Santé Travail Environnement, Université de Bordeaux, Bordeaux, France. isabelle.baldi@isped.u-bordeaux2.fr.

    INSERM U897, Institut de Santé Publique d'Epidémiologie et de Développement, Laboratoire Santé Travail Environnement, Université de Bordeaux, Bordeaux, France. chantal.raherison@isped.u-bordeaux2.fr. Service des Maladies Respiratoires, Hôpital du Haut-Lévèque, Avenue de Magellan, Pessac, France. chantal.raherison@isped.u-bordeaux2.fr.

    Source

    BMC public health 15: 2015 Sep 30 pg 993

    MeSH

    Adult
    Allergens
    Animals
    Asthma
    Child
    Cities
    Cross-Sectional Studies
    Diet
    Feeding Behavior
    Female
    France
    Fruit
    Humans
    Hypersensitivity
    Logistic Models
    Male
    Middle Aged
    Odds Ratio
    Prevalence
    Prospective Studies
    Surveys and Questionnaires
    Urban Population

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26423141

    Citation

    Saadeh, Danielle, et al. "Prevalence and Association of Asthma and Allergic Sensitization With Dietary Factors in Schoolchildren: Data From the French Six Cities Study." BMC Public Health, vol. 15, 2015, p. 993.
    Saadeh D, Salameh P, Caillaud D, et al. Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study. BMC Public Health. 2015;15:993.
    Saadeh, D., Salameh, P., Caillaud, D., Charpin, D., De Blay, F., Kopferschmitt, C., ... Raherison, C. (2015). Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study. BMC Public Health, 15, p. 993. doi:10.1186/s12889-015-2320-2.
    Saadeh D, et al. Prevalence and Association of Asthma and Allergic Sensitization With Dietary Factors in Schoolchildren: Data From the French Six Cities Study. BMC Public Health. 2015 Sep 30;15:993. PubMed PMID: 26423141.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study. AU - Saadeh,Danielle, AU - Salameh,Pascale, AU - Caillaud,Denis, AU - Charpin,Denis, AU - De Blay,Frédéric, AU - Kopferschmitt,Christine, AU - Lavaud,François, AU - Annesi-Maesano,Isabella, AU - Baldi,Isabelle, AU - Raherison,Chantal, Y1 - 2015/09/30/ PY - 2015/05/21/received PY - 2015/09/22/accepted PY - 2015/10/2/entrez PY - 2015/10/2/pubmed PY - 2016/5/14/medline SP - 993 EP - 993 JF - BMC public health JO - BMC Public Health VL - 15 N2 - BACKGROUND: The prevalence of asthma and allergy has recently risen among children. This increase in prevalence might be related to various factors, particularly diet. The aim of this study is to assess the prevalence and association of asthma and allergic sensitization with dietary factors in the French Six Cities Study. METHODS: Cross-sectional studies were performed among 7432 schoolchildren aged 9-11 years in Bordeaux, Clermont-Ferrand, Créteil, Marseille, Reims, and Strasbourg. Parental questionnaires, based on the International Study on Asthma and Allergies in Childhood (ISAAC), were used to collect information on allergic diseases and potential exposure factors including a food frequency questionnaire to evaluate dietary habits. Skin prick testing to common allergens for allergic sensitization and bronchial hyper-responsiveness (BHR) testing to exercise were performed. Confounders control was performed with multiple logistic regressions. RESULTS: Asthma symptoms, asthma and allergic sensitization were more prevalent in boys than in girls and were more prevalent in the South than in the North of France. After adjustment for confounders, fruit juice intake was associated with a low prevalence of lifetime asthma (ORa [95 % CI]; 0.73 [0.56-0.97]), butter intake was positively associated with atopic wheeze (1.48 [1.07-2.05]) and having lunch at the canteen 1-2 times/week compared to never or occasionally was associated with a lower prevalence of past year wheeze (0.71 [0.52-0.96]), lifetime asthma (0.76 [0.60-0.96]) and allergic sensitization (0.80 [0.67-0.95]). Meat intake was inversely related to past year wheeze among atopic children (0.68 [0.50-0.98]) while fast food consumption and butter intake were associated with an increase prevalence of asthma (2.39 [1.47-3.93] and 1.51 [1.17-2.00] respectively). Fish intake was associated with a lower prevalence of asthma among non-atopic children (0.61 [0.43-0.87]. None of the dietary factors was associated with BHR. CONCLUSIONS: Diet is associated with wheeze, asthma and allergic sensitization but not with BHR in children. These results provide further evidence that adherence to a healthy diet including fruits, meat and fish seems to have a protective effect on asthma and allergy in childhood. However, prospective and experimental studies are needed to provide causal evidence concerning the effect of diet on asthma and atopy. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/26423141/full_citation L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-2320-2 DB - PRIME DP - Unbound Medicine ER -