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Burkitt's Lymphoma.
Curr Top Microbiol Immunol 2015; 390(Pt 1):267-85CT

Abstract

Endemic Burkitt's lymphoma (BL) remains the most prevalent pediatric cancer in sub-Saharan Africa even though it was the first human cancer with a viral etiology described over 50 years ago. Epstein-Barr virus (EBV) was discovered in a BL tumor in 1964 and has since been implicated in other malignancies. The etiology of endemic BL has been linked to EBV and Plasmodium falciparum malaria co-infection. While epidemiologic studies have yielded insight into EBV infection and the etiology of endemic BL, the modulation of viral persistence in children by malaria and deficits in EBV immunosurveillance has more recently been reified. Renewed efforts to design prophylactic and therapeutic EBV vaccines provide hope of preventing EBV-associated BL as well as increasing the ability to cure this cancer.

Authors+Show Affiliations

Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA. rochforr@upstate.edu.Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA, 01605, USA. ann.moormann@umassmed.edu.

Pub Type(s)

Historical Article
Journal Article
Review

Language

eng

PubMed ID

26424650

Citation

Rochford, Rosemary, and Ann M. Moormann. "Burkitt's Lymphoma." Current Topics in Microbiology and Immunology, vol. 390, no. Pt 1, 2015, pp. 267-85.
Rochford R, Moormann AM. Burkitt's Lymphoma. Curr Top Microbiol Immunol. 2015;390(Pt 1):267-85.
Rochford, R., & Moormann, A. M. (2015). Burkitt's Lymphoma. Current Topics in Microbiology and Immunology, 390(Pt 1), pp. 267-85. doi:10.1007/978-3-319-22822-8_11.
Rochford R, Moormann AM. Burkitt's Lymphoma. Curr Top Microbiol Immunol. 2015;390(Pt 1):267-85. PubMed PMID: 26424650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burkitt's Lymphoma. AU - Rochford,Rosemary, AU - Moormann,Ann M, PY - 2015/10/2/entrez PY - 2015/10/2/pubmed PY - 2016/3/11/medline SP - 267 EP - 85 JF - Current topics in microbiology and immunology JO - Curr. Top. Microbiol. Immunol. VL - 390 IS - Pt 1 N2 - Endemic Burkitt's lymphoma (BL) remains the most prevalent pediatric cancer in sub-Saharan Africa even though it was the first human cancer with a viral etiology described over 50 years ago. Epstein-Barr virus (EBV) was discovered in a BL tumor in 1964 and has since been implicated in other malignancies. The etiology of endemic BL has been linked to EBV and Plasmodium falciparum malaria co-infection. While epidemiologic studies have yielded insight into EBV infection and the etiology of endemic BL, the modulation of viral persistence in children by malaria and deficits in EBV immunosurveillance has more recently been reified. Renewed efforts to design prophylactic and therapeutic EBV vaccines provide hope of preventing EBV-associated BL as well as increasing the ability to cure this cancer. SN - 0070-217X UR - https://www.unboundmedicine.com/medline/citation/26424650/Burkitt's_Lymphoma_ L2 - https://dx.doi.org/10.1007/978-3-319-22822-8_11 DB - PRIME DP - Unbound Medicine ER -