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Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies.

Abstract

OBJECTIVES

To provide a quantitative assessment of the association between excess body weight, interpreted as increased body mass index (BMI), and the risk of gallbladder cancer (GBC).

METHODS

We identified eligible studies in Medline and EMBASE up to 1 February 2015, and reference lists of retrieved articles. Summary relative risks with their 95% confidence intervals were calculated in a random-effects model. Subgroup analyses were performed according to study design, gender, geographic location, ascertainment of exposure and adjustment for confounders.

RESUITS

A total of 12 cohort studies and 8 case-control studies were included in the meta-analysis. Overall, compared with "normal" weight, the summary relative risks of GBC were 1.14 (95% CI, 1.04-1.25) for overweight individuals (BMI 25-30 kg/m²) and 1.56 (95% CI, 1.41-1.73) for obese individuals (BMI > 30 kg/m²). Obese women had a higher risk of GBC than men did (women: SRRs 1.67, 95% CI 1.38-2.02; men: SRRs 1.42, 95% CI 1.21-1.66), and there was significant association between overweight and GBC risk in women (SRRs 1.26, 95% CI 1.13-1.40), but not in men (SRRs 1.06, 95% CI 0.94-1.20).

CONCLUSIONS

Findings from this meta-analysis indicate that obesity is associated with an increased risk of GBC, especially in women. Overweight is associated with GBC risk only in women.

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  • Authors+Show Affiliations

    ,

    Department of Basical Medicine, Jining Medical University, 16 Hehua Road, Jining 272067, China. lzhzsdxsyx@gmail.com.

    ,

    Department of Clinical Laboratory, Jining NO.1 People's Hospital, 6 Jiankang Road, Jining 272011, China. medchenjun@126.com.

    ,

    Department of Information Technology, Jining Medical University, 16 Hehua Road, Jining 272067, China. liuningsci@126.com.

    ,

    Department of Pathology, Jining Medical University, 16 Hehua Road, Jining 272067, China. zga2007@126.com.

    ,

    Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, 79 Guhuai Road, Jining 272029, China. ciwinglee@126.com.

    Department of Pathology, Jining Medical University, 16 Hehua Road, Jining 272067, China. cuiwenmd@sina.com.

    Source

    Nutrients 7:10 2015 Sep 25 pg 8321-34

    MeSH

    Body Mass Index
    Case-Control Studies
    Cohort Studies
    Female
    Gallbladder Neoplasms
    Gallstones
    Genetic Predisposition to Disease
    Humans
    MEDLINE
    Male
    Obesity
    Overweight
    Risk
    Risk Factors
    Sex Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    26426043

    Citation

    Tan, Wenbin, et al. "Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies." Nutrients, vol. 7, no. 10, 2015, pp. 8321-34.
    Tan W, Gao M, Liu N, et al. Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies. Nutrients. 2015;7(10):8321-34.
    Tan, W., Gao, M., Liu, N., Zhang, G., Xu, T., & Cui, W. (2015). Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 7(10), pp. 8321-34. doi:10.3390/nu7105387.
    Tan W, et al. Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies. Nutrients. 2015 Sep 25;7(10):8321-34. PubMed PMID: 26426043.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies. AU - Tan,Wenbin, AU - Gao,Min, AU - Liu,Ning, AU - Zhang,Guoan, AU - Xu,Tong, AU - Cui,Wen, Y1 - 2015/09/25/ PY - 2015/08/02/received PY - 2015/09/08/revised PY - 2015/09/11/accepted PY - 2015/10/2/entrez PY - 2015/10/2/pubmed PY - 2016/6/29/medline KW - body mass index KW - gallbladder cancer KW - meta-analysis KW - obesity KW - overweight SP - 8321 EP - 34 JF - Nutrients JO - Nutrients VL - 7 IS - 10 N2 - OBJECTIVES: To provide a quantitative assessment of the association between excess body weight, interpreted as increased body mass index (BMI), and the risk of gallbladder cancer (GBC). METHODS: We identified eligible studies in Medline and EMBASE up to 1 February 2015, and reference lists of retrieved articles. Summary relative risks with their 95% confidence intervals were calculated in a random-effects model. Subgroup analyses were performed according to study design, gender, geographic location, ascertainment of exposure and adjustment for confounders. RESUITS: A total of 12 cohort studies and 8 case-control studies were included in the meta-analysis. Overall, compared with "normal" weight, the summary relative risks of GBC were 1.14 (95% CI, 1.04-1.25) for overweight individuals (BMI 25-30 kg/m²) and 1.56 (95% CI, 1.41-1.73) for obese individuals (BMI > 30 kg/m²). Obese women had a higher risk of GBC than men did (women: SRRs 1.67, 95% CI 1.38-2.02; men: SRRs 1.42, 95% CI 1.21-1.66), and there was significant association between overweight and GBC risk in women (SRRs 1.26, 95% CI 1.13-1.40), but not in men (SRRs 1.06, 95% CI 0.94-1.20). CONCLUSIONS: Findings from this meta-analysis indicate that obesity is associated with an increased risk of GBC, especially in women. Overweight is associated with GBC risk only in women. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26426043/Body_Mass_Index_and_Risk_of_Gallbladder_Cancer:_Systematic_Review_and_Meta_Analysis_of_Observational_Studies_ L2 - http://www.mdpi.com/resolver?pii=nu7105387 DB - PRIME DP - Unbound Medicine ER -