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Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases.
Medicine (Baltimore) 2015; 94(39):e1639M

Abstract

Autoimmune thyroid diseases (AITD) are common autoimmune disorders. A few studies have analyzed the association between serum vitamin D levels and AITD, and available data remain inconclusive. The aim of this study was to evaluate the association between serum vitamin D levels and 3 types of AITD, that is Graves' disease (GD), Hashimoto's thyroiditis (HT), and postpartum thyroiditis (PPT). Two independent case-control studies were designed. The first is a cross-sectional case-control study in which we examined the levels of 25(OH)D in patients with newly diagnosed GD or HT and in controls; the second is a nested case-control study in which we compared 25(OH)D levels in 610 women who developed PPT during the follow-up after delivery and those who did not. Compared with the controls, GD patients and HT patients had significantly lower 25(OH)D levels. PPT cases also had a lower serum 25(OH)D concentration than controls. Serum 25(OH)D levels were associated with neither antithyroid peroxidase antibody nor antithyroglobulin antibody in GD and HT. There was no significant relationship between thyroid-stimulating hormone and 25(OH)D levels. Every 5 nmol/L increase in serum 25(OH)D concentrations was associated with a 1.55-, 1.62-, and 1.51-fold reduction in GD, HT, and PPT risk, respectively. We observed a lower serum vitamin D levels in AITD patients compared with controls. The lower the vitamin D level is, not vitamin D deficiency per se, the higher the risk for developing AITD will be. However, vitamin D does not have strong association with the titers of thyroid antibodies or the levels of thyroid hormones.

Authors+Show Affiliations

From the Department of Endocrinology and Metabolism, The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases (JM, DW, CF, NC, JL, YL, RW, WM, HG, ZS, WT), The First Affiliated Hospital of China Medical University; and Department of Gynecology and Obstetrics (CL), Shenyang Women's and Children's Hospital, Shenyang, Liaoning, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26426654

Citation

Ma, Jie, et al. "Lower Serum 25-Hydroxyvitamin D Level Is Associated With 3 Types of Autoimmune Thyroid Diseases." Medicine, vol. 94, no. 39, 2015, pp. e1639.
Ma J, Wu D, Li C, et al. Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases. Medicine (Baltimore). 2015;94(39):e1639.
Ma, J., Wu, D., Li, C., Fan, C., Chao, N., Liu, J., ... Teng, W. (2015). Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases. Medicine, 94(39), pp. e1639. doi:10.1097/MD.0000000000001639.
Ma J, et al. Lower Serum 25-Hydroxyvitamin D Level Is Associated With 3 Types of Autoimmune Thyroid Diseases. Medicine (Baltimore). 2015;94(39):e1639. PubMed PMID: 26426654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases. AU - Ma,Jie, AU - Wu,Di, AU - Li,Chenyang, AU - Fan,Chenling, AU - Chao,Nannan, AU - Liu,Jing, AU - Li,Yushu, AU - Wang,Renee, AU - Miao,Wei, AU - Guan,Haixia, AU - Shan,Zhongyan, AU - Teng,Weiping, PY - 2015/10/2/entrez PY - 2015/10/2/pubmed PY - 2016/1/9/medline SP - e1639 EP - e1639 JF - Medicine JO - Medicine (Baltimore) VL - 94 IS - 39 N2 - Autoimmune thyroid diseases (AITD) are common autoimmune disorders. A few studies have analyzed the association between serum vitamin D levels and AITD, and available data remain inconclusive. The aim of this study was to evaluate the association between serum vitamin D levels and 3 types of AITD, that is Graves' disease (GD), Hashimoto's thyroiditis (HT), and postpartum thyroiditis (PPT). Two independent case-control studies were designed. The first is a cross-sectional case-control study in which we examined the levels of 25(OH)D in patients with newly diagnosed GD or HT and in controls; the second is a nested case-control study in which we compared 25(OH)D levels in 610 women who developed PPT during the follow-up after delivery and those who did not. Compared with the controls, GD patients and HT patients had significantly lower 25(OH)D levels. PPT cases also had a lower serum 25(OH)D concentration than controls. Serum 25(OH)D levels were associated with neither antithyroid peroxidase antibody nor antithyroglobulin antibody in GD and HT. There was no significant relationship between thyroid-stimulating hormone and 25(OH)D levels. Every 5 nmol/L increase in serum 25(OH)D concentrations was associated with a 1.55-, 1.62-, and 1.51-fold reduction in GD, HT, and PPT risk, respectively. We observed a lower serum vitamin D levels in AITD patients compared with controls. The lower the vitamin D level is, not vitamin D deficiency per se, the higher the risk for developing AITD will be. However, vitamin D does not have strong association with the titers of thyroid antibodies or the levels of thyroid hormones. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26426654/Lower_Serum_25_Hydroxyvitamin_D_Level_is_Associated_With_3_Types_of_Autoimmune_Thyroid_Diseases_ L2 - http://Insights.ovid.com/pubmed?pmid=26426654 DB - PRIME DP - Unbound Medicine ER -