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Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria.
Int Arch Allergy Immunol. 2015; 167(4):250-2.IA

Abstract

BACKGROUND

Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic reactions including urticaria, gastrointestinal symptoms or anaphylaxis. We tested the hypothesis that increased levels of IgE to α-Gal due to tick bites and the subsequent ingestion of red meat or meat products may possibly be an un(der)recognized cause of chronic spontaneous urticaria (CSU).

METHODS

Levels of IgE to α-Gal and total IgE were measured (ImmunoCAP, Phadia AB/Thermo Fisher Scientific) in 83 patients (61 female and 22 male, median age 43 years, range 18-82) from the Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany. All had been clinically diagnosed with moderate-to-severe CSU of a median duration of 2.9 years (range 0.1-50).

RESULTS

Eighty of the 83 patients (96%) had undetectable (<0.1 kUA/l) serum levels of IgE against α-Gal. The levels in the remaining 3 were all low (0.25, 0.4 and 3.1 kUA/l). In no patient, including those with measurable serum levels of IgE against α-Gal, was eating red meat associated with the development of symptoms of urticaria.

CONCLUSION

Our results indicate that an allergic response to α-Gal is highly unlikely to be a hitherto unrecognized common cause of CSU.

Authors+Show Affiliations

Department of Dermatology and Allergy, Allergie-Centrum-Charitx00E9;, Charitx00E9; - Universitx00E4;tsmedizin Berlin, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26426899

Citation

Maurer, Marcus, et al. "Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria." International Archives of Allergy and Immunology, vol. 167, no. 4, 2015, pp. 250-2.
Maurer M, Church MK, Metz M, et al. Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria. Int Arch Allergy Immunol. 2015;167(4):250-2.
Maurer, M., Church, M. K., Metz, M., Starkhammar, M., Hamsten, C., & van Hage, M. (2015). Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria. International Archives of Allergy and Immunology, 167(4), 250-2. https://doi.org/10.1159/000440653
Maurer M, et al. Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria. Int Arch Allergy Immunol. 2015;167(4):250-2. PubMed PMID: 26426899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria. AU - Maurer,Marcus, AU - Church,Martin K, AU - Metz,Martin, AU - Starkhammar,Maria, AU - Hamsten,Carl, AU - van Hage,Marianne, Y1 - 2015/10/02/ PY - 2015/07/07/received PY - 2015/08/17/accepted PY - 2015/10/2/entrez PY - 2015/10/2/pubmed PY - 2016/4/23/medline SP - 250 EP - 2 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 167 IS - 4 N2 - BACKGROUND: Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic reactions including urticaria, gastrointestinal symptoms or anaphylaxis. We tested the hypothesis that increased levels of IgE to α-Gal due to tick bites and the subsequent ingestion of red meat or meat products may possibly be an un(der)recognized cause of chronic spontaneous urticaria (CSU). METHODS: Levels of IgE to α-Gal and total IgE were measured (ImmunoCAP, Phadia AB/Thermo Fisher Scientific) in 83 patients (61 female and 22 male, median age 43 years, range 18-82) from the Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany. All had been clinically diagnosed with moderate-to-severe CSU of a median duration of 2.9 years (range 0.1-50). RESULTS: Eighty of the 83 patients (96%) had undetectable (<0.1 kUA/l) serum levels of IgE against α-Gal. The levels in the remaining 3 were all low (0.25, 0.4 and 3.1 kUA/l). In no patient, including those with measurable serum levels of IgE against α-Gal, was eating red meat associated with the development of symptoms of urticaria. CONCLUSION: Our results indicate that an allergic response to α-Gal is highly unlikely to be a hitherto unrecognized common cause of CSU. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/26426899/Galactose_α_13_Galactose_Allergy_Is_Not_a_Hitherto_Unrecognized_Cause_of_Chronic_Spontaneous_Urticaria_ L2 - https://www.karger.com?DOI=10.1159/000440653 DB - PRIME DP - Unbound Medicine ER -