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Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit-derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry.
Contact Dermatitis. 2015 Dec; 73(6):358-63.CD

Abstract

BACKGROUND

Fruit-derived organic compounds and detergents are relevant exposure factors for occupational contact dermatitis in the food industry. Although individuals with atopic dermatitis (AD) are at risk for development of occupational contact dermatitis, there have been no controlled studies on the effects of repeated exposure to multiple irritants, relevant for the food industry, in atopic skin.

OBJECTIVES

The aim of the study was to investigate the outcomes of repeated exposure to a fruit-derived organic acid and a detergent in AD compared to healthy volunteers.

METHODS

The volunteers were exposed to 2.0% acetic acid (AcA) and/or 0.5% sodium lauryl sulfate (SLS) in controlled tandem repeated irritation test. The outcomes were assessed by measurements of erythema, transepidermal water loss (TEWL) and natural moisturizing factor (NMF) levels.

RESULTS

In the AD volunteers, repeated AcA exposure led to barrier disruption and significant TEWL increase; no significant differences after the same exposure in the healthy controls were found. Repeated exposure to SLS and the irritant tandems enhanced the reactions and resulted in a significantly higher increase in TEWL in the AD compared to the control group. Cumulative irritant exposure reduced the NMF levels in both groups.

CONCLUSIONS

Differences in the severity of irritant-induced barrier impairment in atopic individuals contribute to the risk for occupational contact dermatitis in result of multiple exposures to food-derived irritants and detergents.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Angelova-Fischer I
Department of Dermatology, University of Lübeck, 23538, Lübeck, Germany. Comprehensive Center for Inflammation Medicine, University Hospital Schleswig-Holstein, 23538, Lübeck, Germany.
Hoek AK
Department of Dermatology, University of Lübeck, 23538, Lübeck, Germany.
Dapic I
Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000, Zagreb, Croatia.
Jakasa I
Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000, Zagreb, Croatia.
Kezic S
Coronel Institute of Occupational Health, Academic Medical Centre, 1100 AZ, Amsterdam, The Netherlands.
Fischer TW
Department of Dermatology, University of Lübeck, 23538, Lübeck, Germany.
Zillikens D
Department of Dermatology, University of Lübeck, 23538, Lübeck, Germany.

MeSH

Acetic AcidAdultAgedDermatitis, Allergic ContactDermatitis, OccupationalDetergentsFemaleFood IndustryFruitHand DermatosesHumansMaleMiddle AgedSkinSodium Dodecyl SulfateWater Loss, InsensibleYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26426984

Citation

Angelova-Fischer, Irena, et al. "Barrier Function and Natural Moisturizing Factor Levels After Cumulative Exposure to a Fruit-derived Organic Acid and a Detergent: Different Outcomes in Atopic and Healthy Skin and Relevance for Occupational Contact Dermatitis in the Food Industry." Contact Dermatitis, vol. 73, no. 6, 2015, pp. 358-63.
Angelova-Fischer I, Hoek AK, Dapic I, et al. Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit-derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry. Contact Dermatitis. 2015;73(6):358-63.
Angelova-Fischer, I., Hoek, A. K., Dapic, I., Jakasa, I., Kezic, S., Fischer, T. W., & Zillikens, D. (2015). Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit-derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry. Contact Dermatitis, 73(6), 358-63. https://doi.org/10.1111/cod.12464
Angelova-Fischer I, et al. Barrier Function and Natural Moisturizing Factor Levels After Cumulative Exposure to a Fruit-derived Organic Acid and a Detergent: Different Outcomes in Atopic and Healthy Skin and Relevance for Occupational Contact Dermatitis in the Food Industry. Contact Dermatitis. 2015;73(6):358-63. PubMed PMID: 26426984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit-derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry. AU - Angelova-Fischer,Irena, AU - Hoek,Anne-Karin, AU - Dapic,Irena, AU - Jakasa,Ivone, AU - Kezic,Sanja, AU - Fischer,Tobias W, AU - Zillikens,Detlef, Y1 - 2015/10/01/ PY - 2015/03/24/received PY - 2015/07/21/revised PY - 2015/07/25/accepted PY - 2015/10/2/entrez PY - 2015/10/2/pubmed PY - 2016/10/19/medline KW - atopic dermatitis KW - fruit-derived organic acids KW - irritant hand eczema KW - natural moisturizing factor KW - occupational contact dermatitis KW - skin barrier function KW - sodium lauryl sulfate SP - 358 EP - 63 JF - Contact dermatitis JO - Contact Dermatitis VL - 73 IS - 6 N2 - BACKGROUND: Fruit-derived organic compounds and detergents are relevant exposure factors for occupational contact dermatitis in the food industry. Although individuals with atopic dermatitis (AD) are at risk for development of occupational contact dermatitis, there have been no controlled studies on the effects of repeated exposure to multiple irritants, relevant for the food industry, in atopic skin. OBJECTIVES: The aim of the study was to investigate the outcomes of repeated exposure to a fruit-derived organic acid and a detergent in AD compared to healthy volunteers. METHODS: The volunteers were exposed to 2.0% acetic acid (AcA) and/or 0.5% sodium lauryl sulfate (SLS) in controlled tandem repeated irritation test. The outcomes were assessed by measurements of erythema, transepidermal water loss (TEWL) and natural moisturizing factor (NMF) levels. RESULTS: In the AD volunteers, repeated AcA exposure led to barrier disruption and significant TEWL increase; no significant differences after the same exposure in the healthy controls were found. Repeated exposure to SLS and the irritant tandems enhanced the reactions and resulted in a significantly higher increase in TEWL in the AD compared to the control group. Cumulative irritant exposure reduced the NMF levels in both groups. CONCLUSIONS: Differences in the severity of irritant-induced barrier impairment in atopic individuals contribute to the risk for occupational contact dermatitis in result of multiple exposures to food-derived irritants and detergents. SN - 1600-0536 UR - https://www.unboundmedicine.com/medline/citation/26426984/Barrier_function_and_natural_moisturizing_factor_levels_after_cumulative_exposure_to_a_fruit_derived_organic_acid_and_a_detergent:_different_outcomes_in_atopic_and_healthy_skin_and_relevance_for_occupational_contact_dermatitis_in_the_food_industry_ DB - PRIME DP - Unbound Medicine ER -