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Chondrosarcoma of the hyoid bone: a case report.
Rom J Morphol Embryol. 2015; 56(2 Suppl):811-6.RJ

Abstract

Chondrosarcoma is a malignancy of the mesenchymal tissue derived from transformed cells that produce the cartilage matrix. In the neck area, it represents less than 0.5% of malignant tumor pathology. Chondrosarcoma of the hyoid bone is extremely rare, only 20 cases having been published so far (PubMed 2014). We present the case of a 30-year-old patient from the urban area, admitted in the ENT (Ear, Nose & Throat) Emergency Service with inspiratory dyspnea, dysphagia, stomatolalia, with evolutive and progressive clinical history of 2-3 months. Endoscopic examination revealed a pharyngolaryngeal tumor process located in the right vallecula, who by mass effect displaces the above-hyoid epiglottis. CT (computerized tomography) scan described a cervical polycystic tumor aspect, with multiple septae and inside calcifications with a diameter of 3-4 mm. Surgery consisted in removal of the tumor process together with the hyoid bone. Histopathological and especially immunohistochemical examination established the diagnosis of low-grade chondrosarcoma of the hyoid bone. For assessment of the phenotype of the tumor cells, the following immunohistochemical markers were used: p53, Ki67. The patient followed radiochemotherapic oncological treatment and returned for regular follow-ups. There was a positive development with no signs of regional or remote relapse or metastasis for 24 months after surgical treatment. Surgery is the treatment of choice, with complete removal of the tumor, with chemoradiation playing an adjuvant role. Regular tracking of the patient is mandatory.

Authors+Show Affiliations

ENT Clinic, University of Medicine and Pharmacy of Craiova, Romania; carmen_mogo@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26429177

Citation

Ciolofan, Mircea Sorin, et al. "Chondrosarcoma of the Hyoid Bone: a Case Report." Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie, vol. 56, no. 2 Suppl, 2015, pp. 811-6.
Ciolofan MS, Ioniţă E, Ioniţă I, et al. Chondrosarcoma of the hyoid bone: a case report. Rom J Morphol Embryol. 2015;56(2 Suppl):811-6.
Ciolofan, M. S., Ioniţă, E., Ioniţă, I., Mogoantă, C. A., Anghelina, F., Enescu, A. Ş., Ciobîrcă, D. M., Osman, A., Foarfă, M. C., & Mateescu, G. O. (2015). Chondrosarcoma of the hyoid bone: a case report. Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie, 56(2 Suppl), 811-6.
Ciolofan MS, et al. Chondrosarcoma of the Hyoid Bone: a Case Report. Rom J Morphol Embryol. 2015;56(2 Suppl):811-6. PubMed PMID: 26429177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chondrosarcoma of the hyoid bone: a case report. AU - Ciolofan,Mircea Sorin, AU - Ioniţă,Elena, AU - Ioniţă,Iulică, AU - Mogoantă,Carmen Aurelia, AU - Anghelina,Florin, AU - Enescu,Anca Ştefania, AU - Ciobîrcă,Diana Maria, AU - Osman,Andrei, AU - Foarfă,Maria Camelia, AU - Mateescu,Garofiţa Olivia, PY - 2015/10/3/entrez PY - 2015/10/3/pubmed PY - 2016/5/11/medline SP - 811 EP - 6 JF - Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie JO - Rom J Morphol Embryol VL - 56 IS - 2 Suppl N2 - Chondrosarcoma is a malignancy of the mesenchymal tissue derived from transformed cells that produce the cartilage matrix. In the neck area, it represents less than 0.5% of malignant tumor pathology. Chondrosarcoma of the hyoid bone is extremely rare, only 20 cases having been published so far (PubMed 2014). We present the case of a 30-year-old patient from the urban area, admitted in the ENT (Ear, Nose & Throat) Emergency Service with inspiratory dyspnea, dysphagia, stomatolalia, with evolutive and progressive clinical history of 2-3 months. Endoscopic examination revealed a pharyngolaryngeal tumor process located in the right vallecula, who by mass effect displaces the above-hyoid epiglottis. CT (computerized tomography) scan described a cervical polycystic tumor aspect, with multiple septae and inside calcifications with a diameter of 3-4 mm. Surgery consisted in removal of the tumor process together with the hyoid bone. Histopathological and especially immunohistochemical examination established the diagnosis of low-grade chondrosarcoma of the hyoid bone. For assessment of the phenotype of the tumor cells, the following immunohistochemical markers were used: p53, Ki67. The patient followed radiochemotherapic oncological treatment and returned for regular follow-ups. There was a positive development with no signs of regional or remote relapse or metastasis for 24 months after surgical treatment. Surgery is the treatment of choice, with complete removal of the tumor, with chemoradiation playing an adjuvant role. Regular tracking of the patient is mandatory. SN - 1220-0522 UR - https://www.unboundmedicine.com/medline/citation/26429177/Chondrosarcoma_of_the_hyoid_bone:_a_case_report_ L2 - http://www.rjme.ro/RJME/resources/files/561215811816.pdf DB - PRIME DP - Unbound Medicine ER -