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Putting the periodicity back into the periodic leg movement index: an alternative data-driven algorithm for the computation of this index during sleep and wakefulness.
Sleep Med. 2015 Oct; 16(10):1229-35.SM

Abstract

OBJECTIVE

To evaluate an alternative index for periodic leg movements during sleep (PLMS) and wakefulness (PLMW) expected to be similar to the standard index when leg movement activity is genuinely periodic, but significantly lower when periodicity is low.

SUBJECTS AND METHODS

One-hundred-and-seven subjects with restless legs syndrome (RLS) were retrospectively identified and included (47 males, 60 females, mean age 56.9 years), along with 63 controls (33 males, 30 females, 42.2 years). Night-to-night variability was analysed in a subgroup of 17 subjects with RLS. PLMW were evaluated in a subgroup of 66 RLS subjects. Two 'alternative' PLMS/PLMW indices were calculated: one increased the lower limit of the inter-movement intervals from 5 to 10 s ('Alt1') and another additionally considered only series not interrupted by LMs with a short inter-movement interval ('Alt2').

RESULTS

Despite a high correlation between methods, only the Alt2 algorithm provided significantly different results, with PLMS/PLMW indices being consistently lower than those provided by the other two methods. The difference was more evident in the controls and during wakefulness, when periodicity was lower. The difference between the Alt2 and the standard PLMS index showed a significantly negative correlation with the Periodicity Index. Night-to-night variability was similar for all PLMS indices and significantly higher than the variability seen in the Periodicity Index.

CONCLUSION

This methodological study introduces an alternative to the standard PLMS/PLMW indices, initiating the validation process for a new way of computing the PLMS/PLMW index, more adherent to the parameters that allows a reliable evaluation of their periodicity.

Authors+Show Affiliations

Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy. Electronic address: rferri@oasi.en.it.Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.Sleep Disorders Center, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Vita-Salute University, Milan, Italy.Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.Department of Social and Developmental Psychology, Sapienza University, Rome, Italy.Sleep Disorders Center, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Vita-Salute University, Milan, Italy.Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26429751

Citation

Ferri, Raffaele, et al. "Putting the Periodicity Back Into the Periodic Leg Movement Index: an Alternative Data-driven Algorithm for the Computation of This Index During Sleep and Wakefulness." Sleep Medicine, vol. 16, no. 10, 2015, pp. 1229-35.
Ferri R, Rundo F, Zucconi M, et al. Putting the periodicity back into the periodic leg movement index: an alternative data-driven algorithm for the computation of this index during sleep and wakefulness. Sleep Med. 2015;16(10):1229-35.
Ferri, R., Rundo, F., Zucconi, M., Manconi, M., Aricò, D., Bruni, O., Ferini-Strambi, L., & Fulda, S. (2015). Putting the periodicity back into the periodic leg movement index: an alternative data-driven algorithm for the computation of this index during sleep and wakefulness. Sleep Medicine, 16(10), 1229-35. https://doi.org/10.1016/j.sleep.2015.05.019
Ferri R, et al. Putting the Periodicity Back Into the Periodic Leg Movement Index: an Alternative Data-driven Algorithm for the Computation of This Index During Sleep and Wakefulness. Sleep Med. 2015;16(10):1229-35. PubMed PMID: 26429751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Putting the periodicity back into the periodic leg movement index: an alternative data-driven algorithm for the computation of this index during sleep and wakefulness. AU - Ferri,Raffaele, AU - Rundo,Francesco, AU - Zucconi,Marco, AU - Manconi,Mauro, AU - Aricò,Debora, AU - Bruni,Oliviero, AU - Ferini-Strambi,Luigi, AU - Fulda,Stephany, Y1 - 2015/06/26/ PY - 2015/01/26/received PY - 2015/03/30/revised PY - 2015/05/06/accepted PY - 2015/10/3/entrez PY - 2015/10/3/pubmed PY - 2016/8/3/medline KW - Index KW - PLMS KW - PLMW KW - Periodic leg movements during sleep KW - Restless legs syndrome KW - Sleep scoring SP - 1229 EP - 35 JF - Sleep medicine JO - Sleep Med VL - 16 IS - 10 N2 - OBJECTIVE: To evaluate an alternative index for periodic leg movements during sleep (PLMS) and wakefulness (PLMW) expected to be similar to the standard index when leg movement activity is genuinely periodic, but significantly lower when periodicity is low. SUBJECTS AND METHODS: One-hundred-and-seven subjects with restless legs syndrome (RLS) were retrospectively identified and included (47 males, 60 females, mean age 56.9 years), along with 63 controls (33 males, 30 females, 42.2 years). Night-to-night variability was analysed in a subgroup of 17 subjects with RLS. PLMW were evaluated in a subgroup of 66 RLS subjects. Two 'alternative' PLMS/PLMW indices were calculated: one increased the lower limit of the inter-movement intervals from 5 to 10 s ('Alt1') and another additionally considered only series not interrupted by LMs with a short inter-movement interval ('Alt2'). RESULTS: Despite a high correlation between methods, only the Alt2 algorithm provided significantly different results, with PLMS/PLMW indices being consistently lower than those provided by the other two methods. The difference was more evident in the controls and during wakefulness, when periodicity was lower. The difference between the Alt2 and the standard PLMS index showed a significantly negative correlation with the Periodicity Index. Night-to-night variability was similar for all PLMS indices and significantly higher than the variability seen in the Periodicity Index. CONCLUSION: This methodological study introduces an alternative to the standard PLMS/PLMW indices, initiating the validation process for a new way of computing the PLMS/PLMW index, more adherent to the parameters that allows a reliable evaluation of their periodicity. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/26429751/Putting_the_periodicity_back_into_the_periodic_leg_movement_index:_an_alternative_data_driven_algorithm_for_the_computation_of_this_index_during_sleep_and_wakefulness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(15)00826-6 DB - PRIME DP - Unbound Medicine ER -