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A longitudinal study of accommodative changes in biometry during incipient presbyopia.
Ophthalmic Physiol Opt. 2016 Jan; 36(1):33-42.OP

Abstract

PURPOSE

To profile accommodative biometric changes longitudinally and to determine the influence of age-related ocular structural changes on the accommodative response prior to the onset of presbyopia.

METHODS

Twenty participants (aged 34-41 years) were reviewed at six-monthly intervals over two and a half years. At each visit, ocular biometry was measured with the LenStar biometer (www.Haag-Streit.com) in response to 0.00, 3.00 and 4.50 D stimuli. Accommodative responses were measured by the WAM 5500 Auto Ref/Keratometer (www.grandseiko.com).

RESULTS

During accommodation, anterior chamber depth reduced (F = 29, p < 0.001), whereas crystalline lens thickness (F = 39, p < 0.001) and axial length (F = 5.4, p = 0.009) increased. The accommodative response (F = 5.5, p = 0.001) and the change in anterior chamber depth (F = 3.1, p = 0.039), crystalline lens thickness (F = 3.0, p = 0.042) and axial length (F = 2.5, p = 0.038) in response to the 4.50 D accommodative target reduced after 2.5 years. However, the change in anterior chamber depth (F = 2.2, p = 0.097), crystalline lens thickness (F = 1.7, p = 0.18) and axial length (F = 1.0, p = 0.40) per dioptre of accommodation exerted remained invariant after 2.5 years. The increase in disaccommodated crystalline lens thickness with age was not significantly associated with the reduction in accommodative response (R = 0.32, p = 0.17).

CONCLUSION

Despite significant age-related structural changes in disaccommodated biometry, the change in biometry per dioptre of accommodation exerted remained invariant with age. The present study supports the Helmholtz theory of accommodation and suggests an increase in lenticular stiffness is primarily responsible for the onset of presbyopia.

Authors+Show Affiliations

Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham, UK.Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham, UK.Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26432063

Citation

Laughton, Deborah S., et al. "A Longitudinal Study of Accommodative Changes in Biometry During Incipient Presbyopia." Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists), vol. 36, no. 1, 2016, pp. 33-42.
Laughton DS, Sheppard AL, Davies LN. A longitudinal study of accommodative changes in biometry during incipient presbyopia. Ophthalmic Physiol Opt. 2016;36(1):33-42.
Laughton, D. S., Sheppard, A. L., & Davies, L. N. (2016). A longitudinal study of accommodative changes in biometry during incipient presbyopia. Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists), 36(1), 33-42. https://doi.org/10.1111/opo.12242
Laughton DS, Sheppard AL, Davies LN. A Longitudinal Study of Accommodative Changes in Biometry During Incipient Presbyopia. Ophthalmic Physiol Opt. 2016;36(1):33-42. PubMed PMID: 26432063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A longitudinal study of accommodative changes in biometry during incipient presbyopia. AU - Laughton,Deborah S, AU - Sheppard,Amy L, AU - Davies,Leon N, Y1 - 2015/10/02/ PY - 2015/05/27/received PY - 2015/08/07/accepted PY - 2015/10/4/entrez PY - 2015/10/4/pubmed PY - 2016/9/17/medline KW - accommodation KW - biometry KW - crystalline lens KW - presbyopia SP - 33 EP - 42 JF - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JO - Ophthalmic Physiol Opt VL - 36 IS - 1 N2 - PURPOSE: To profile accommodative biometric changes longitudinally and to determine the influence of age-related ocular structural changes on the accommodative response prior to the onset of presbyopia. METHODS: Twenty participants (aged 34-41 years) were reviewed at six-monthly intervals over two and a half years. At each visit, ocular biometry was measured with the LenStar biometer (www.Haag-Streit.com) in response to 0.00, 3.00 and 4.50 D stimuli. Accommodative responses were measured by the WAM 5500 Auto Ref/Keratometer (www.grandseiko.com). RESULTS: During accommodation, anterior chamber depth reduced (F = 29, p < 0.001), whereas crystalline lens thickness (F = 39, p < 0.001) and axial length (F = 5.4, p = 0.009) increased. The accommodative response (F = 5.5, p = 0.001) and the change in anterior chamber depth (F = 3.1, p = 0.039), crystalline lens thickness (F = 3.0, p = 0.042) and axial length (F = 2.5, p = 0.038) in response to the 4.50 D accommodative target reduced after 2.5 years. However, the change in anterior chamber depth (F = 2.2, p = 0.097), crystalline lens thickness (F = 1.7, p = 0.18) and axial length (F = 1.0, p = 0.40) per dioptre of accommodation exerted remained invariant after 2.5 years. The increase in disaccommodated crystalline lens thickness with age was not significantly associated with the reduction in accommodative response (R = 0.32, p = 0.17). CONCLUSION: Despite significant age-related structural changes in disaccommodated biometry, the change in biometry per dioptre of accommodation exerted remained invariant with age. The present study supports the Helmholtz theory of accommodation and suggests an increase in lenticular stiffness is primarily responsible for the onset of presbyopia. SN - 1475-1313 UR - https://www.unboundmedicine.com/medline/citation/26432063/A_longitudinal_study_of_accommodative_changes_in_biometry_during_incipient_presbyopia_ L2 - https://doi.org/10.1111/opo.12242 DB - PRIME DP - Unbound Medicine ER -