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A population-based analysis of Head and Neck hemangiopericytoma.
Laryngoscope. 2016 Mar; 126(3):643-50.L

Abstract

OBJECTIVES/HYPOTHESIS

Hemangiopericytomas (HPC) are tumors that arise from pericytes. Hemangiopericytomas of the head and neck are rare and occur both extracranially and intracranially. This study analyzes the demographic, clinicopathologic, treatment modalities, and survival characteristics of extracranial head and neck hemangiopericytomas (HN-HPC) and compares them to HPCs at other body sites (Other-HPC).

METHODS

The Surveillance, Epidemiology, and End Results (SEER) database (1973-2012) was queried for HN-HPC (121 cases) and Other-HPC (510 cases). Data were analyzed comparatively with respect to various demographic and clinicopathologic factors. Disease-specific survival (DSS) was analyzed using the Kaplan-Meier model.

RESULTS

There was no significant difference in age at time of diagnosis between HN-HPC and Other-HPC. Head and neck HPC was most commonly located in the connective and soft tissue (18.4%), followed by the nasal cavity and paranasal sinuses (8.5%). Head and neck HPCs were smaller than Other-HPC (P < 0.0001) and more likely to be a lower histologic grade (P < 0.0097). The primary treatment modality for HN-HPC was surgery alone, used in 55.8% of cases. The 5-, 10-, and 20-year DSS for HN-HPC were 84.0%, 79.4%, and 69.4%, respectfully. Higher histologic grade and the presence of distant metastases were poor prognostic factors for HN-HPC.

CONCLUSION

Head and neck HPCs are rare tumors. This study represents the largest series of HN-HPCs to date. Surgery alone is the primary treatment modality for HN-HPC, with a favorable prognosis. Adjuvant radiotherapy does not appear to confer a survival benefit for any body site.

LEVEL OF EVIDENCE

4. Laryngoscope, 126:643-650, 2016.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery.Department of Otolaryngology-Head and Neck Surgery.Department of Otolaryngology-Head and Neck Surgery.Department of Otolaryngology-Head and Neck Surgery.Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey.Department of Otolaryngology-Head and Neck Surgery. Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey. Department of Neurological Surgery. Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26434421

Citation

Shaigany, Kevin, et al. "A Population-based Analysis of Head and Neck Hemangiopericytoma." The Laryngoscope, vol. 126, no. 3, 2016, pp. 643-50.
Shaigany K, Fang CH, Patel TD, et al. A population-based analysis of Head and Neck hemangiopericytoma. Laryngoscope. 2016;126(3):643-50.
Shaigany, K., Fang, C. H., Patel, T. D., Park, R. C., Baredes, S., & Eloy, J. A. (2016). A population-based analysis of Head and Neck hemangiopericytoma. The Laryngoscope, 126(3), 643-50. https://doi.org/10.1002/lary.25681
Shaigany K, et al. A Population-based Analysis of Head and Neck Hemangiopericytoma. Laryngoscope. 2016;126(3):643-50. PubMed PMID: 26434421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based analysis of Head and Neck hemangiopericytoma. AU - Shaigany,Kevin, AU - Fang,Christina H, AU - Patel,Tapan D, AU - Park,Richard Chan, AU - Baredes,Soly, AU - Eloy,Jean Anderson, Y1 - 2015/10/05/ PY - 2015/06/09/received PY - 2015/08/03/revised PY - 2015/08/24/accepted PY - 2015/10/6/entrez PY - 2015/10/6/pubmed PY - 2016/6/23/medline KW - Hemangiopericytoma KW - SEER KW - comparative analysis KW - disease-specific survival KW - extracranial hemangiopericytoma KW - head and neck cancer KW - head and neck tumor KW - survival KW - vascular tumor SP - 643 EP - 50 JF - The Laryngoscope JO - Laryngoscope VL - 126 IS - 3 N2 - OBJECTIVES/HYPOTHESIS: Hemangiopericytomas (HPC) are tumors that arise from pericytes. Hemangiopericytomas of the head and neck are rare and occur both extracranially and intracranially. This study analyzes the demographic, clinicopathologic, treatment modalities, and survival characteristics of extracranial head and neck hemangiopericytomas (HN-HPC) and compares them to HPCs at other body sites (Other-HPC). METHODS: The Surveillance, Epidemiology, and End Results (SEER) database (1973-2012) was queried for HN-HPC (121 cases) and Other-HPC (510 cases). Data were analyzed comparatively with respect to various demographic and clinicopathologic factors. Disease-specific survival (DSS) was analyzed using the Kaplan-Meier model. RESULTS: There was no significant difference in age at time of diagnosis between HN-HPC and Other-HPC. Head and neck HPC was most commonly located in the connective and soft tissue (18.4%), followed by the nasal cavity and paranasal sinuses (8.5%). Head and neck HPCs were smaller than Other-HPC (P < 0.0001) and more likely to be a lower histologic grade (P < 0.0097). The primary treatment modality for HN-HPC was surgery alone, used in 55.8% of cases. The 5-, 10-, and 20-year DSS for HN-HPC were 84.0%, 79.4%, and 69.4%, respectfully. Higher histologic grade and the presence of distant metastases were poor prognostic factors for HN-HPC. CONCLUSION: Head and neck HPCs are rare tumors. This study represents the largest series of HN-HPCs to date. Surgery alone is the primary treatment modality for HN-HPC, with a favorable prognosis. Adjuvant radiotherapy does not appear to confer a survival benefit for any body site. LEVEL OF EVIDENCE: 4. Laryngoscope, 126:643-650, 2016. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/26434421/A_population_based_analysis_of_Head_and_Neck_hemangiopericytoma_ L2 - https://doi.org/10.1002/lary.25681 DB - PRIME DP - Unbound Medicine ER -