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Statins and their increased risk of inducing diabetes.
Expert Opin Drug Saf 2015; 14(12):1835-44EO

Abstract

INTRODUCTION

Statins are evidence-based drugs to prevent cardiovascular (CV) disease. However, their benefits have been disputed by a statin-related increased risk of new onset diabetes (NOD) in randomized controlled trials and meta-analyses.

AREAS COVERED

This review provides an update based on recent outstanding evidence on the statin effect on the risk of diabetes. It also describes mechanisms potentially explaining adverse effects of statins on glucose homeostasis. PubMed was searched for original articles and reviews published from January 2010 (inclusive) to May 2015 (inclusive), which include the Search terms statins, diabetes, glucose, and insulin. NOD risk seems to be more relevant with high-intensity rather than with low-intensity statin treatment. Also, this risk is particularly increased in patients at risk for the development of diabetes. It appears that statins adversely affect glucose homeostasis in parallel with their 3-hydroxy-3-methylglutaryl-coenzyme A inhibition capacity. It was suggested that lipophilic statins are more diabetogenic than the hydrophilic ones. Mechanisms explaining statin diabetogeneicity include impaired insulin secretion by pancreatic β cells together with increased insulin resistance of various tissues.

EXPERT OPINION

The CV outcome benefits from statin use outweigh the diabetes menace. However, patients at risk for the development of diabetes should be prescribed statins with caution.

Authors+Show Affiliations

a 1 Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free London Foundation Trust , Pond Street, London, UK. b 2 University of Ioannina, Department of Internal Medicine, Medical School , GR 45110 Ioannina, Greece +30 26 51 00 75 09 ; +30 26 51 00 70 16 ; egepi@cc.uoi.gr.c 3 Cambridge University Hospitals NHS Foundation Trust, Clinical Pharmacology Unit, Addenbrooke's Hospital , Cambridge, UK.b 2 University of Ioannina, Department of Internal Medicine, Medical School , GR 45110 Ioannina, Greece +30 26 51 00 75 09 ; +30 26 51 00 70 16 ; egepi@cc.uoi.gr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26437128

Citation

Agouridis, Aris P., et al. "Statins and Their Increased Risk of Inducing Diabetes." Expert Opinion On Drug Safety, vol. 14, no. 12, 2015, pp. 1835-44.
Agouridis AP, Kostapanos MS, Elisaf MS. Statins and their increased risk of inducing diabetes. Expert Opin Drug Saf. 2015;14(12):1835-44.
Agouridis, A. P., Kostapanos, M. S., & Elisaf, M. S. (2015). Statins and their increased risk of inducing diabetes. Expert Opinion On Drug Safety, 14(12), pp. 1835-44. doi:10.1517/14740338.2015.1096343.
Agouridis AP, Kostapanos MS, Elisaf MS. Statins and Their Increased Risk of Inducing Diabetes. Expert Opin Drug Saf. 2015;14(12):1835-44. PubMed PMID: 26437128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statins and their increased risk of inducing diabetes. AU - Agouridis,Aris P, AU - Kostapanos,Michael S, AU - Elisaf,Moses S, Y1 - 2015/10/05/ PY - 2015/10/6/entrez PY - 2015/10/6/pubmed PY - 2016/9/7/medline KW - cardiovascular disease KW - new onset diabetes KW - statin SP - 1835 EP - 44 JF - Expert opinion on drug safety JO - Expert Opin Drug Saf VL - 14 IS - 12 N2 - INTRODUCTION: Statins are evidence-based drugs to prevent cardiovascular (CV) disease. However, their benefits have been disputed by a statin-related increased risk of new onset diabetes (NOD) in randomized controlled trials and meta-analyses. AREAS COVERED: This review provides an update based on recent outstanding evidence on the statin effect on the risk of diabetes. It also describes mechanisms potentially explaining adverse effects of statins on glucose homeostasis. PubMed was searched for original articles and reviews published from January 2010 (inclusive) to May 2015 (inclusive), which include the Search terms statins, diabetes, glucose, and insulin. NOD risk seems to be more relevant with high-intensity rather than with low-intensity statin treatment. Also, this risk is particularly increased in patients at risk for the development of diabetes. It appears that statins adversely affect glucose homeostasis in parallel with their 3-hydroxy-3-methylglutaryl-coenzyme A inhibition capacity. It was suggested that lipophilic statins are more diabetogenic than the hydrophilic ones. Mechanisms explaining statin diabetogeneicity include impaired insulin secretion by pancreatic β cells together with increased insulin resistance of various tissues. EXPERT OPINION: The CV outcome benefits from statin use outweigh the diabetes menace. However, patients at risk for the development of diabetes should be prescribed statins with caution. SN - 1744-764X UR - https://www.unboundmedicine.com/medline/citation/26437128/Statins_and_their_increased_risk_of_inducing_diabetes_ L2 - http://www.tandfonline.com/doi/full/10.1517/14740338.2015.1096343 DB - PRIME DP - Unbound Medicine ER -