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Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System.
Molecules. 2015 Sep 30; 20(10):17929-43.M

Abstract

In this work, a two-step extraction methodology of ionic liquid-based ultrasonic-assisted extraction (IL-UAE) and ionic liquid-based aqueous two-phase system (IL-ATPS) was developed for the extraction and purification of secoisolariciresinol diglucoside (SDG) from flaxseed. In the IL-UAE step, several kinds of ILs were investigated as the extractants, to identify the IL that affords the optimum extraction yield. The extraction conditions such as IL concentration, ultrasonic irradiation time, and liquid-solid ratio were optimized using response surface methodology (RSM). In the IL-ATPS step, ATPS formed by adding kosmotropic salts to the IL extract was used for further separation and purification of SDG. The most influential parameters (type and concentration of salt, temperature, and pH) were investigated to obtain the optimum extraction efficiency. The maximum extraction efficiency was 93.35% under the optimal conditions of 45.86% (w/w) IL and 8.27% (w/w) Na₂SO₄ at 22 °C and pH 11.0. Thus, the combination of IL-UAE and IL-ATPS makes up a simple and effective methodology for the extraction and purification of SDG. This process is also expected to be highly useful for the extraction and purification of bioactive compounds from other important medicinal plants.

Authors+Show Affiliations

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China. tanzhijiantgzy2010@aliyun.com.Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China. ibfcwcy@139.com.College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. yzz8582352@163.com.Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China. ibfcyyj@163.com.Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China. Cswhy328@126.com.Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China. aruofly@126.com.College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. lfflqq@csu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26437389

Citation

Tan, Zhi-Jian, et al. "Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside From Flaxseed (Linum Usitatissimum L.) With Further Purification By an Aqueous Two-Phase System." Molecules (Basel, Switzerland), vol. 20, no. 10, 2015, pp. 17929-43.
Tan ZJ, Wang CY, Yang ZZ, et al. Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System. Molecules. 2015;20(10):17929-43.
Tan, Z. J., Wang, C. Y., Yang, Z. Z., Yi, Y. J., Wang, H. Y., Zhou, W. L., & Li, F. F. (2015). Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System. Molecules (Basel, Switzerland), 20(10), 17929-43. https://doi.org/10.3390/molecules201017929
Tan ZJ, et al. Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside From Flaxseed (Linum Usitatissimum L.) With Further Purification By an Aqueous Two-Phase System. Molecules. 2015 Sep 30;20(10):17929-43. PubMed PMID: 26437389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System. AU - Tan,Zhi-Jian, AU - Wang,Chao-Yun, AU - Yang,Zi-Zhen, AU - Yi,Yong-Jian, AU - Wang,Hong-Ying, AU - Zhou,Wan-Lai, AU - Li,Fen-Fang, Y1 - 2015/09/30/ PY - 2015/07/06/received PY - 2015/08/31/revised PY - 2015/09/10/accepted PY - 2015/10/6/entrez PY - 2015/10/6/pubmed PY - 2016/6/28/medline KW - aqueous two-phase system KW - ionic liquid KW - purification KW - secoisolariciresinol diglucoside KW - ultrasonic-assisted extraction SP - 17929 EP - 43 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 20 IS - 10 N2 - In this work, a two-step extraction methodology of ionic liquid-based ultrasonic-assisted extraction (IL-UAE) and ionic liquid-based aqueous two-phase system (IL-ATPS) was developed for the extraction and purification of secoisolariciresinol diglucoside (SDG) from flaxseed. In the IL-UAE step, several kinds of ILs were investigated as the extractants, to identify the IL that affords the optimum extraction yield. The extraction conditions such as IL concentration, ultrasonic irradiation time, and liquid-solid ratio were optimized using response surface methodology (RSM). In the IL-ATPS step, ATPS formed by adding kosmotropic salts to the IL extract was used for further separation and purification of SDG. The most influential parameters (type and concentration of salt, temperature, and pH) were investigated to obtain the optimum extraction efficiency. The maximum extraction efficiency was 93.35% under the optimal conditions of 45.86% (w/w) IL and 8.27% (w/w) Na₂SO₄ at 22 °C and pH 11.0. Thus, the combination of IL-UAE and IL-ATPS makes up a simple and effective methodology for the extraction and purification of SDG. This process is also expected to be highly useful for the extraction and purification of bioactive compounds from other important medicinal plants. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/26437389/Ionic_Liquid_Based_Ultrasonic_Assisted_Extraction_of_Secoisolariciresinol_Diglucoside_from_Flaxseed__Linum_usitatissimum_L___with_Further_Purification_by_an_Aqueous_Two_Phase_System_ L2 - http://www.mdpi.com/resolver?pii=molecules201017929 DB - PRIME DP - Unbound Medicine ER -