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Detection of deep-vein thrombosis by real-time B-mode ultrasonography.
N Engl J Med. 1989 Feb 09; 320(6):342-5.NEJM

Abstract

In 220 consecutive outpatients with clinically suspected deep-vein thrombosis of the leg, we compared contrast venography with real-time B-mode ultrasonography, using the single criterion of vein compressibility with the ultrasound transducer probe. The common femoral and popliteal veins were evaluated for full compressibility (no thrombosis) and noncompressibility (thrombosis). Both veins were fully compressible in 142 of the 143 patients with normal venograms (specificity, 99 percent; 95 percent confidence interval, 97 to 100). All 66 patients with proximal-vein thrombosis had noncompressible femoral veins, popliteal veins, or both (sensitivity, 100 percent; 95 percent confidence interval, 95 to 100). For all patients (including 11 with calf-vein thrombi), sensitivity and specificity were 91 (95 percent confidence interval, 82 to 96) and 99 percent, respectively. The sensitivity for isolated calf-vein thrombosis was only 36 percent. The compression ultrasound test was repeated in a subset of 45 consecutive patients by a second examiner, unaware of the results of the first test, whose results agreed in all patients with those of the first examiner (kappa = 1). We conclude that ultrasonography with the single criterion of vein compressibility is a highly accurate, simple, objective, and reproducible noninvasive method for detecting proximal-vein thrombosis in outpatients with clinically suspected deep-venous thrombosis.

Authors+Show Affiliations

Lensing AW
Center for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Center, Amsterdam, the Netherlands.
Prandoni P
No affiliation info available
Brandjes D
No affiliation info available
Huisman PM
No affiliation info available
Vigo M
No affiliation info available
Tomasella G
No affiliation info available
Krekt J
No affiliation info available
Wouter Ten Cate J
No affiliation info available
Huisman MV
No affiliation info available
Büller HR
No affiliation info available

MeSH

Femoral VeinHumansPhlebographyPopliteal VeinProspective StudiesThrombophlebitisTransducersUltrasonography

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2643771

Clinical Trial Links

Mortality Due to Malignancy in Patients With Idiopathic Venous Thromboembolism

Citation

Lensing, A W., et al. "Detection of Deep-vein Thrombosis By Real-time B-mode Ultrasonography." The New England Journal of Medicine, vol. 320, no. 6, 1989, pp. 342-5.
Lensing AW, Prandoni P, Brandjes D, et al. Detection of deep-vein thrombosis by real-time B-mode ultrasonography. N Engl J Med. 1989;320(6):342-5.
Lensing, A. W., Prandoni, P., Brandjes, D., Huisman, P. M., Vigo, M., Tomasella, G., Krekt, J., Wouter Ten Cate, J., Huisman, M. V., & Büller, H. R. (1989). Detection of deep-vein thrombosis by real-time B-mode ultrasonography. The New England Journal of Medicine, 320(6), 342-5.
Lensing AW, et al. Detection of Deep-vein Thrombosis By Real-time B-mode Ultrasonography. N Engl J Med. 1989 Feb 9;320(6):342-5. PubMed PMID: 2643771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of deep-vein thrombosis by real-time B-mode ultrasonography. AU - Lensing,A W, AU - Prandoni,P, AU - Brandjes,D, AU - Huisman,P M, AU - Vigo,M, AU - Tomasella,G, AU - Krekt,J, AU - Wouter Ten Cate,J, AU - Huisman,M V, AU - Büller,H R, PY - 1989/2/9/pubmed PY - 1989/2/9/medline PY - 1989/2/9/entrez SP - 342 EP - 5 JF - The New England journal of medicine JO - N Engl J Med VL - 320 IS - 6 N2 - In 220 consecutive outpatients with clinically suspected deep-vein thrombosis of the leg, we compared contrast venography with real-time B-mode ultrasonography, using the single criterion of vein compressibility with the ultrasound transducer probe. The common femoral and popliteal veins were evaluated for full compressibility (no thrombosis) and noncompressibility (thrombosis). Both veins were fully compressible in 142 of the 143 patients with normal venograms (specificity, 99 percent; 95 percent confidence interval, 97 to 100). All 66 patients with proximal-vein thrombosis had noncompressible femoral veins, popliteal veins, or both (sensitivity, 100 percent; 95 percent confidence interval, 95 to 100). For all patients (including 11 with calf-vein thrombi), sensitivity and specificity were 91 (95 percent confidence interval, 82 to 96) and 99 percent, respectively. The sensitivity for isolated calf-vein thrombosis was only 36 percent. The compression ultrasound test was repeated in a subset of 45 consecutive patients by a second examiner, unaware of the results of the first test, whose results agreed in all patients with those of the first examiner (kappa = 1). We conclude that ultrasonography with the single criterion of vein compressibility is a highly accurate, simple, objective, and reproducible noninvasive method for detecting proximal-vein thrombosis in outpatients with clinically suspected deep-venous thrombosis. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/2643771/Detection_of_deep_vein_thrombosis_by_real_time_B_mode_ultrasonography_ DB - PRIME DP - Unbound Medicine ER -