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Cancers in Australia in 2010 attributable to and prevented by the use of menopausal hormone therapy.
Aust N Z J Public Health. 2015 Oct; 39(5):434-40.AN

Abstract

OBJECTIVES

To estimate the proportion and number of cancers occurring in Australia in 2010 attributable to menopausal hormone therapy (MHT) use.

METHODS

We estimated the population attributable fraction for cancers causally associated with MHT (breast, endometrium, ovary), and the proportion of colorectal cancers prevented by MHT. We used standard formulae incorporating Australian prevalence data, relative risks of cancer associated with MHT and cancer incidence. We also estimated potential change in cancer incidence under two hypothetical scenarios whereby 25% fewer Australian women used MHT, or women exclusively used oestrogen-only MHT.

RESULTS

An estimated 539 cancers in Australia in 2010 were attributable to MHT: 453 breast, 67 endometrial and 19 ovarian cancers equating to 3.4%, 3.1% and 1.6% of each cancer type, respectively. In contrast, MHT may have prevented 52 colorectal cancers. If 25% fewer women used MHT, then 141 cancers may have been avoided. If women exclusively used oestrogen-only MHT then 240 cancers may have been avoided.

CONCLUSIONS

MHT use caused more than 500 cancers in Australian women in 2010 and prevented ∼50 colorectal cancers.

IMPLICATIONS

MHT use continues to cause an excess of cancers. The risks, benefits, regimen and treatment duration should be carefully considered for each woman before MHT is commenced.

Links

Authors+Show Affiliations

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland.

QIMR Berghofer Medical Research Institute, Queensland.

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland.

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland. Cancer Research UK, Manchester Institute and Institute of Inflammation and Repair, University of Manchester, United Kingdom.

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland.

QIMR Berghofer Medical Research Institute, Queensland. National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Australian Capital Territory.

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland.

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland.

QIMR Berghofer Medical Research Institute, Queensland. School of Public Health, The University of Queensland.

MeSH

AdultAustraliaBreast NeoplasmsColorectal NeoplasmsEndometrial NeoplasmsEstrogen Replacement TherapyFemaleHumansIncidenceMenopauseMiddle AgedOvarian NeoplasmsPrevalenceRisk AssessmentRisk Factors

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26437728

Citation

Jordan, Susan J., et al. "Cancers in Australia in 2010 Attributable to and Prevented By the Use of Menopausal Hormone Therapy." Australian and New Zealand Journal of Public Health, vol. 39, no. 5, 2015, pp. 434-40.

Jordan SJ, Wilson LF, Nagle CM, et al. Cancers in Australia in 2010 attributable to and prevented by the use of menopausal hormone therapy. Aust N Z J Public Health. 2015;39(5):434-40.

Jordan, S. J., Wilson, L. F., Nagle, C. M., Green, A. C., Olsen, C. M., Bain, C. J., Pandeya, N., Whiteman, D. C., & Webb, P. M. (2015). Cancers in Australia in 2010 attributable to and prevented by the use of menopausal hormone therapy. Australian and New Zealand Journal of Public Health, 39(5), 434-40. https://doi.org/10.1111/1753-6405.12451

Jordan SJ, et al. Cancers in Australia in 2010 Attributable to and Prevented By the Use of Menopausal Hormone Therapy. Aust N Z J Public Health. 2015;39(5):434-40. PubMed PMID: 26437728.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Cancers in Australia in 2010 attributable to and prevented by the use of menopausal hormone therapy. AU - Jordan,Susan J, AU - Wilson,Louise F, AU - Nagle,Christina M, AU - Green,Adele C, AU - Olsen,Catherine M, AU - Bain,Christopher J, AU - Pandeya,Nirmala, AU - Whiteman,David C, AU - Webb,Penelope M, PY - 2015/03/01/received PY - 2015/04/01/revised PY - 2015/05/01/accepted PY - 2015/10/7/entrez PY - 2015/10/7/pubmed PY - 2016/7/12/medline KW - cancer KW - menopausal hormone therapy KW - population attributable fraction KW - potential impact fraction KW - risk factor SP - 434 EP - 40 JF - Australian and New Zealand journal of public health JO - Aust N Z J Public Health VL - 39 IS - 5 N2 - OBJECTIVES: To estimate the proportion and number of cancers occurring in Australia in 2010 attributable to menopausal hormone therapy (MHT) use. METHODS: We estimated the population attributable fraction for cancers causally associated with MHT (breast, endometrium, ovary), and the proportion of colorectal cancers prevented by MHT. We used standard formulae incorporating Australian prevalence data, relative risks of cancer associated with MHT and cancer incidence. We also estimated potential change in cancer incidence under two hypothetical scenarios whereby 25% fewer Australian women used MHT, or women exclusively used oestrogen-only MHT. RESULTS: An estimated 539 cancers in Australia in 2010 were attributable to MHT: 453 breast, 67 endometrial and 19 ovarian cancers equating to 3.4%, 3.1% and 1.6% of each cancer type, respectively. In contrast, MHT may have prevented 52 colorectal cancers. If 25% fewer women used MHT, then 141 cancers may have been avoided. If women exclusively used oestrogen-only MHT then 240 cancers may have been avoided. CONCLUSIONS: MHT use caused more than 500 cancers in Australian women in 2010 and prevented ∼50 colorectal cancers. IMPLICATIONS: MHT use continues to cause an excess of cancers. The risks, benefits, regimen and treatment duration should be carefully considered for each woman before MHT is commenced. SN - 1753-6405 UR - https://www.unboundmedicine.com/medline/citation/26437728/Cancers_in_Australia_in_2010_attributable_to_and_prevented_by_the_use_of_menopausal_hormone_therapy_ DB - PRIME DP - Unbound Medicine ER -