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Effect of Milk Powder Supplementation with Different Calcium Contents on Bone Mineral Density of Postmenopausal Women in Northern China: A Randomized Controlled Double-Blind Trial.
Calcif Tissue Int. 2016 Jan; 98(1):60-6.CT

Abstract

The objective of this study is to examine the effect of milk powder supplementation with different calcium contents on bone mineral density (BMD) in postmenopausal Chinese women, and to determine a more appropriate dose of calcium supplementation. A 2-year, randomized controlled double-blind trial. Postmenopausal women (n = 210) aged 50-65 years were recruited and assigned randomly into three calcium supplementation groups. All participants received milk powder supplementation with different calcium contents (300, 600, and 900 mg per day for groups A, B, and C, respectively) and all groups received 800 IU of vitamin D per day. During the follow-up period, BMD of the left hip and lumbar spine (as the main indicator) was measured using dual-energy X-ray absorptiometry at the baseline, 1 and 2 years. Both three BMD measures and the changes of BMD over 2 years were used to analyze. Before adjusting for covariates, BMD in group A of the lumbar spine and groups A and B of greater trochanter decreased significantly from the baseline over time but increased significantly in the rest groups of the lumbar spine and greater trochanter and in three groups of Ward's triangle. There were significant differences across the three groups for changes of BMD in the greater trochanter and Ward's triangle. When adjusting for covariates, there were significant decreases with time in group A of the spine (P = 0.001), groups A and B of greater trochanter (P = 0.0002 and P = 0.04, respectively) and increases in groups B and C of Ward's triangle (P = 0.03 and P = 0.004, respectively). BMD change in the greater trochanter was significantly different among three groups. For healthy postmenopausal women, high calcium milk powder supplementation was better in retarding bone loss than medium and low calcium in the greater trochanter. Considering the dietary calcium intake of postmenopausal women in north of China, a dose of 900 mg/day is considered as the most appropriate calcium supplementation for greater trochanter but not for other sites.

Authors+Show Affiliations

Department of Biostatistics, Public Health College, Harbin Medical University, Baojian Road 157, Harbin City, Heilongjiang Province, China.Department of Biostatistics, Public Health College, Harbin Medical University, Baojian Road 157, Harbin City, Heilongjiang Province, China.Department of Biostatistics, Public Health College, Harbin Medical University, Baojian Road 157, Harbin City, Heilongjiang Province, China.Medical Department, Harbin Medical University, Baojian Road 157, Harbin City, Heilongjiang Province, China.The Healthy City Construction Guidance Center of Hangzhou City, Yanan Road 484, Hangzhou City, Zhejiang Province, China.The Center of Disease Control and Prevention of Ningbo City, Yongfeng Road 237, Hangzhou City, Zhejiang Province, China.Department of Biostatistics, Public Health College, Harbin Medical University, Baojian Road 157, Harbin City, Heilongjiang Province, China. liumeina369@163.com.Department of Biostatistics, Public Health College, Harbin Medical University, Baojian Road 157, Harbin City, Heilongjiang Province, China. zqj81129@sina.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26438518

Citation

Chen, Yongjie, et al. "Effect of Milk Powder Supplementation With Different Calcium Contents On Bone Mineral Density of Postmenopausal Women in Northern China: a Randomized Controlled Double-Blind Trial." Calcified Tissue International, vol. 98, no. 1, 2016, pp. 60-6.
Chen Y, Xiao Y, Xie B, et al. Effect of Milk Powder Supplementation with Different Calcium Contents on Bone Mineral Density of Postmenopausal Women in Northern China: A Randomized Controlled Double-Blind Trial. Calcif Tissue Int. 2016;98(1):60-6.
Chen, Y., Xiao, Y., Xie, B., Zhang, Q., Ma, X., Li, N., Liu, M., & Zhang, Q. (2016). Effect of Milk Powder Supplementation with Different Calcium Contents on Bone Mineral Density of Postmenopausal Women in Northern China: A Randomized Controlled Double-Blind Trial. Calcified Tissue International, 98(1), 60-6. https://doi.org/10.1007/s00223-015-0065-7
Chen Y, et al. Effect of Milk Powder Supplementation With Different Calcium Contents On Bone Mineral Density of Postmenopausal Women in Northern China: a Randomized Controlled Double-Blind Trial. Calcif Tissue Int. 2016;98(1):60-6. PubMed PMID: 26438518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Milk Powder Supplementation with Different Calcium Contents on Bone Mineral Density of Postmenopausal Women in Northern China: A Randomized Controlled Double-Blind Trial. AU - Chen,Yongjie, AU - Xiao,Yaming, AU - Xie,Biao, AU - Zhang,Qiao, AU - Ma,Xianfu, AU - Li,Ning, AU - Liu,Meina, AU - Zhang,Qiuju, Y1 - 2015/10/06/ PY - 2015/07/04/received PY - 2015/09/25/accepted PY - 2015/10/7/entrez PY - 2015/10/7/pubmed PY - 2016/11/12/medline KW - Bone mineral density KW - Calcium supplementation KW - Osteoporosis KW - Postmenopausal women SP - 60 EP - 6 JF - Calcified tissue international JO - Calcif Tissue Int VL - 98 IS - 1 N2 - The objective of this study is to examine the effect of milk powder supplementation with different calcium contents on bone mineral density (BMD) in postmenopausal Chinese women, and to determine a more appropriate dose of calcium supplementation. A 2-year, randomized controlled double-blind trial. Postmenopausal women (n = 210) aged 50-65 years were recruited and assigned randomly into three calcium supplementation groups. All participants received milk powder supplementation with different calcium contents (300, 600, and 900 mg per day for groups A, B, and C, respectively) and all groups received 800 IU of vitamin D per day. During the follow-up period, BMD of the left hip and lumbar spine (as the main indicator) was measured using dual-energy X-ray absorptiometry at the baseline, 1 and 2 years. Both three BMD measures and the changes of BMD over 2 years were used to analyze. Before adjusting for covariates, BMD in group A of the lumbar spine and groups A and B of greater trochanter decreased significantly from the baseline over time but increased significantly in the rest groups of the lumbar spine and greater trochanter and in three groups of Ward's triangle. There were significant differences across the three groups for changes of BMD in the greater trochanter and Ward's triangle. When adjusting for covariates, there were significant decreases with time in group A of the spine (P = 0.001), groups A and B of greater trochanter (P = 0.0002 and P = 0.04, respectively) and increases in groups B and C of Ward's triangle (P = 0.03 and P = 0.004, respectively). BMD change in the greater trochanter was significantly different among three groups. For healthy postmenopausal women, high calcium milk powder supplementation was better in retarding bone loss than medium and low calcium in the greater trochanter. Considering the dietary calcium intake of postmenopausal women in north of China, a dose of 900 mg/day is considered as the most appropriate calcium supplementation for greater trochanter but not for other sites. SN - 1432-0827 UR - https://www.unboundmedicine.com/medline/citation/26438518/Effect_of_Milk_Powder_Supplementation_with_Different_Calcium_Contents_on_Bone_Mineral_Density_of_Postmenopausal_Women_in_Northern_China:_A_Randomized_Controlled_Double_Blind_Trial_ L2 - https://dx.doi.org/10.1007/s00223-015-0065-7 DB - PRIME DP - Unbound Medicine ER -