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H2S: A Novel Gasotransmitter that Signals by Sulfhydration.
Trends Biochem Sci. 2015 Nov; 40(11):687-700.TB

Abstract

Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S.

Authors+Show Affiliations

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: bpaul8@jhmi.edu.The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: ssnyder@jhmi.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

26439534

Citation

Paul, Bindu D., and Solomon H. Snyder. "H2S: a Novel Gasotransmitter That Signals By Sulfhydration." Trends in Biochemical Sciences, vol. 40, no. 11, 2015, pp. 687-700.
Paul BD, Snyder SH. H2S: A Novel Gasotransmitter that Signals by Sulfhydration. Trends Biochem Sci. 2015;40(11):687-700.
Paul, B. D., & Snyder, S. H. (2015). H2S: A Novel Gasotransmitter that Signals by Sulfhydration. Trends in Biochemical Sciences, 40(11), 687-700. https://doi.org/10.1016/j.tibs.2015.08.007
Paul BD, Snyder SH. H2S: a Novel Gasotransmitter That Signals By Sulfhydration. Trends Biochem Sci. 2015;40(11):687-700. PubMed PMID: 26439534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - H2S: A Novel Gasotransmitter that Signals by Sulfhydration. AU - Paul,Bindu D, AU - Snyder,Solomon H, Y1 - 2015/10/01/ PY - 2015/04/22/received PY - 2015/08/13/revised PY - 2015/08/18/accepted PY - 2015/10/7/entrez PY - 2015/10/7/pubmed PY - 2016/6/9/medline KW - cysteine KW - gasotransmitter KW - hydrogen sulfide KW - sulfhydration SP - 687 EP - 700 JF - Trends in biochemical sciences JO - Trends Biochem Sci VL - 40 IS - 11 N2 - Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S. SN - 0968-0004 UR - https://www.unboundmedicine.com/medline/citation/26439534/H2S:_A_Novel_Gasotransmitter_that_Signals_by_Sulfhydration_ DB - PRIME DP - Unbound Medicine ER -
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