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Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis).
Lipids. 2015 Dec; 50(12):1219-32.L

Abstract

The aim of this study was to evaluate the impact of replacing dietary fish oil (FO) with linseed oil (LO) on growth, fatty acid composition and regulation of lipid metabolism in Eurasian perch (Perca fluviatilis) juveniles. Fish (17.5 g initial body weight) were fed isoproteic and isoenergetic diets containing 116 g/kg of lipid for 10 weeks. Fish fed the LO diet displayed lower growth rates and lower levels of DHA in the liver and muscle than fish fed the FO diet, while mortality was not affected by dietary treatment. However, DHA content recorded in the liver and muscle of fish fed the LO diet remained relatively high, despite a weight gain of 134 % and a reduced dietary level of long-chain polyunsaturated fatty acids (LC-PUFA), suggesting endogenous LC-PUFA biosynthesis. This was supported by the higher amounts of pathway intermediates, including 18:4n-3, 20:3n-3, 20:4n-3, 18:3n-6 and 20:3n-6, recorded in the liver of fish fed the LO diet in comparison with those fed the FO diet. However, fads2 and elovl5 gene expression and FADS2 enzyme activity were comparable between the two groups. Similarly, the expression of genes involved in eicosanoid synthesis was not modulated by dietary LO. Thus, the present study demonstrated that in fish fed LO for 10 weeks, growth was reduced but DHA levels in tissues were largely maintained compared to fish fed FO, suggesting a physiologically relevant rate of endogenous LC-PUFA biosynthesis capacity.

Authors+Show Affiliations

Research Unit in Environmental and Evolutionary Biology (URBE), University of Namur (UNamur), Rue de Bruxelles 61, 5000, Namur, Belgium.Research Unit in Environmental and Evolutionary Biology (URBE), University of Namur (UNamur), Rue de Bruxelles 61, 5000, Namur, Belgium.Institut des Sciences de la Vie, UCLouvain, Croix du Sud, 2/L7.05.08, 1348, Louvain-La-Neuve, Belgium.Unité de Chimie Physique Théorique et Structurale, Université de Namur (UNamur), Rue de Bruxelles 61, 5000, Namur, Belgium.Research Unit in Environmental and Evolutionary Biology (URBE), University of Namur (UNamur), Rue de Bruxelles 61, 5000, Namur, Belgium.Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling, FK9 4LA, Scotland, UK.Institut des Sciences de la Vie, UCLouvain, Croix du Sud, 2/L7.05.08, 1348, Louvain-La-Neuve, Belgium.Institut des Sciences de la Vie, UCLouvain, Croix du Sud, 2/L7.05.08, 1348, Louvain-La-Neuve, Belgium.Research Unit in Environmental and Evolutionary Biology (URBE), University of Namur (UNamur), Rue de Bruxelles 61, 5000, Namur, Belgium. patrick.kestemont@unamur.be.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26439838

Citation

Geay, F, et al. "Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion Into Tissues in Eurasian Perch (Perca Fluviatilis)." Lipids, vol. 50, no. 12, 2015, pp. 1219-32.
Geay F, Wenon D, Mellery J, et al. Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis). Lipids. 2015;50(12):1219-32.
Geay, F., Wenon, D., Mellery, J., Tinti, E., Mandiki, S. N., Tocher, D. R., Debier, C., Larondelle, Y., & Kestemont, P. (2015). Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis). Lipids, 50(12), 1219-32. https://doi.org/10.1007/s11745-015-4079-8
Geay F, et al. Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion Into Tissues in Eurasian Perch (Perca Fluviatilis). Lipids. 2015;50(12):1219-32. PubMed PMID: 26439838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis). AU - Geay,F, AU - Wenon,D, AU - Mellery,J, AU - Tinti,E, AU - Mandiki,S N M, AU - Tocher,D R, AU - Debier,C, AU - Larondelle,Y, AU - Kestemont,P, Y1 - 2015/10/06/ PY - 2015/07/22/received PY - 2015/09/04/accepted PY - 2015/10/7/entrez PY - 2015/10/7/pubmed PY - 2016/9/13/medline KW - Eicosanoid KW - Eurasian perch KW - FADS2 KW - Fatty acid metabolism KW - LC-PUFA SP - 1219 EP - 32 JF - Lipids JO - Lipids VL - 50 IS - 12 N2 - The aim of this study was to evaluate the impact of replacing dietary fish oil (FO) with linseed oil (LO) on growth, fatty acid composition and regulation of lipid metabolism in Eurasian perch (Perca fluviatilis) juveniles. Fish (17.5 g initial body weight) were fed isoproteic and isoenergetic diets containing 116 g/kg of lipid for 10 weeks. Fish fed the LO diet displayed lower growth rates and lower levels of DHA in the liver and muscle than fish fed the FO diet, while mortality was not affected by dietary treatment. However, DHA content recorded in the liver and muscle of fish fed the LO diet remained relatively high, despite a weight gain of 134 % and a reduced dietary level of long-chain polyunsaturated fatty acids (LC-PUFA), suggesting endogenous LC-PUFA biosynthesis. This was supported by the higher amounts of pathway intermediates, including 18:4n-3, 20:3n-3, 20:4n-3, 18:3n-6 and 20:3n-6, recorded in the liver of fish fed the LO diet in comparison with those fed the FO diet. However, fads2 and elovl5 gene expression and FADS2 enzyme activity were comparable between the two groups. Similarly, the expression of genes involved in eicosanoid synthesis was not modulated by dietary LO. Thus, the present study demonstrated that in fish fed LO for 10 weeks, growth was reduced but DHA levels in tissues were largely maintained compared to fish fed FO, suggesting a physiologically relevant rate of endogenous LC-PUFA biosynthesis capacity. SN - 1558-9307 UR - https://www.unboundmedicine.com/medline/citation/26439838/Dietary_Linseed_Oil_Reduces_Growth_While_Differentially_Impacting_LC_PUFA_Synthesis_and_Accretion_into_Tissues_in_Eurasian_Perch__Perca_fluviatilis__ L2 - https://link.springer.com/article/10.1007/s11745-015-4079-8 DB - PRIME DP - Unbound Medicine ER -