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Fixed ratio or lower limit of normal for the FEV1 /VC ratio: relation to symptoms and extended lung function tests.
Clin Physiol Funct Imaging. 2017 May; 37(3):263-269.CP

Abstract

There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. European Respiratory Society and American Thoracic Society favour the use of the fifth percentile of the age-related FEV1 /FVC ratio (the lower limit of normal, LLN). The purpose of this study was to analyse extensive lung function tests in groups of subjects fulfilling none, either or both of the spirometric criteria for COPD. From a previous population-based study, 450 subjects were examined with spirometry, body pletysmography diffusing capacity for CO (DL,CO), Impulse Oscillometry System (IOS) and answered a questionnaire on respiratory symptoms and diseases. Seventy subjects fulfilled both spirometric COPD criteria (FR+LLN+), 62 subjects the fixed ratio criterion (FR+) only. Of the remaining 318 subjects, 236 were ever smokers (N-ES). Significant differences between all groups were seen for FEV1 and DL,CO . Significant differences between groups were also seen for residual volume (RV) and RV/total lung capacity. For IOS, variables and symptoms increasingly abnormal values were seen from never smokers to FR+LLN+. This study shows that subjects meeting both spirometric COPD criteria frequently have symptoms and findings at extended lung function tests compatible with the diagnosis. Also subjects meeting the fixed ratio criterion only tend to have more symptoms and lung function findings compatible with COPD than ever-smoking subjects with FEV1 /VC > 0·7.

Authors+Show Affiliations

Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Lund University, Malmö, Sweden.Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Lund University, Malmö, Sweden.Department of Clinical Sciences, Cardio-vascular Epidemiology, Lund University, Malmö, Sweden.Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Lund University, Malmö, Sweden.Department of Clinical Sciences, Respiratory Medicine and Allergology, Lund University, Lund, Sweden.Department of Clinical Sciences, Respiratory Medicine and Allergology, Lund University, Lund, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26443700

Citation

Wollmer, Per, et al. "Fixed Ratio or Lower Limit of Normal for the FEV1 /VC Ratio: Relation to Symptoms and Extended Lung Function Tests." Clinical Physiology and Functional Imaging, vol. 37, no. 3, 2017, pp. 263-269.
Wollmer P, Frantz S, Engström G, et al. Fixed ratio or lower limit of normal for the FEV1 /VC ratio: relation to symptoms and extended lung function tests. Clin Physiol Funct Imaging. 2017;37(3):263-269.
Wollmer, P., Frantz, S., Engström, G., Dencker, M., Löfdahl, C. G., & Nihlén, U. (2017). Fixed ratio or lower limit of normal for the FEV1 /VC ratio: relation to symptoms and extended lung function tests. Clinical Physiology and Functional Imaging, 37(3), 263-269. https://doi.org/10.1111/cpf.12294
Wollmer P, et al. Fixed Ratio or Lower Limit of Normal for the FEV1 /VC Ratio: Relation to Symptoms and Extended Lung Function Tests. Clin Physiol Funct Imaging. 2017;37(3):263-269. PubMed PMID: 26443700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fixed ratio or lower limit of normal for the FEV1 /VC ratio: relation to symptoms and extended lung function tests. AU - Wollmer,Per, AU - Frantz,Sophia, AU - Engström,Gunnar, AU - Dencker,Magnus, AU - Löfdahl,Claes-Göran, AU - Nihlén,Ulf, Y1 - 2015/10/06/ PY - 2014/11/06/received PY - 2015/06/29/accepted PY - 2015/10/8/pubmed PY - 2017/10/24/medline PY - 2015/10/8/entrez KW - Impulse Oscillometry System KW - chronic obstructive pulmonary disease KW - diagnosis KW - diffusing capacity for CO KW - spirometry SP - 263 EP - 269 JF - Clinical physiology and functional imaging JO - Clin Physiol Funct Imaging VL - 37 IS - 3 N2 - There is no general agreement on the spirometric definition of chronic obstructive pulmonary disease (COPD). The global initiative for obstructive lung disease recommends a fixed ratio between forced expiratory volume in one-second (FEV1) and forced vital capacity (FVC) of <0·7 (FR) for the diagnosis of COPD. European Respiratory Society and American Thoracic Society favour the use of the fifth percentile of the age-related FEV1 /FVC ratio (the lower limit of normal, LLN). The purpose of this study was to analyse extensive lung function tests in groups of subjects fulfilling none, either or both of the spirometric criteria for COPD. From a previous population-based study, 450 subjects were examined with spirometry, body pletysmography diffusing capacity for CO (DL,CO), Impulse Oscillometry System (IOS) and answered a questionnaire on respiratory symptoms and diseases. Seventy subjects fulfilled both spirometric COPD criteria (FR+LLN+), 62 subjects the fixed ratio criterion (FR+) only. Of the remaining 318 subjects, 236 were ever smokers (N-ES). Significant differences between all groups were seen for FEV1 and DL,CO . Significant differences between groups were also seen for residual volume (RV) and RV/total lung capacity. For IOS, variables and symptoms increasingly abnormal values were seen from never smokers to FR+LLN+. This study shows that subjects meeting both spirometric COPD criteria frequently have symptoms and findings at extended lung function tests compatible with the diagnosis. Also subjects meeting the fixed ratio criterion only tend to have more symptoms and lung function findings compatible with COPD than ever-smoking subjects with FEV1 /VC > 0·7. SN - 1475-097X UR - https://www.unboundmedicine.com/medline/citation/26443700/Fixed_ratio_or_lower_limit_of_normal_for_the_FEV1_/VC_ratio:_relation_to_symptoms_and_extended_lung_function_tests_ L2 - https://doi.org/10.1111/cpf.12294 DB - PRIME DP - Unbound Medicine ER -