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The Intestinal Microbiota and Irritable Bowel Syndrome.
J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S56-9.JC

Abstract

Irritable bowel syndrome (IBS) is the most prevalent and the best studied functional gastrointestinal disorder. The etiology and the pathogenesis of IBS are still not clear; however, recent studies have implicated a role for alterations in the intestinal microbiota (dysbiosis) in the pathophysiology of the disorder. Epidemiological observations have demonstrated that the development of IBS symptoms is often preceded by a disruption of the individual's normal intestinal microbiota, and microbiological studies have demonstrated compositional differences in the intestinal microbiota between patients with IBS patients and healthy controls. In addition, animal studies and a few recent human clinical studies have demonstrated that compositional changes in the intestinal microbiota in IBS are associated with relevant abnormal gastrointestinal and brain-gut axis functions that are often observed in patients with IBS. This article discusses points of interest from the current research on the microbiota-gut-brain interactions in IBS and highlights the relevance of the emerging data to our understanding of the disorder and the clinical implications for patients' care.

Authors+Show Affiliations

*Rabin Medical Center, Division of Gastroenterology, Beilinson Hospital, Petah Tikva, Israel †UNC Center for Functional GI & Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine ‡Department of Maternal and Child Health, UNC Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26447966

Citation

Ringel, Yehuda, and Tamar Ringel-Kulka. "The Intestinal Microbiota and Irritable Bowel Syndrome." Journal of Clinical Gastroenterology, vol. 49 Suppl 1, 2015, pp. S56-9.
Ringel Y, Ringel-Kulka T. The Intestinal Microbiota and Irritable Bowel Syndrome. J Clin Gastroenterol. 2015;49 Suppl 1:S56-9.
Ringel, Y., & Ringel-Kulka, T. (2015). The Intestinal Microbiota and Irritable Bowel Syndrome. Journal of Clinical Gastroenterology, 49 Suppl 1, S56-9. https://doi.org/10.1097/MCG.0000000000000418
Ringel Y, Ringel-Kulka T. The Intestinal Microbiota and Irritable Bowel Syndrome. J Clin Gastroenterol. 2015 Nov-Dec;49 Suppl 1:S56-9. PubMed PMID: 26447966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Intestinal Microbiota and Irritable Bowel Syndrome. AU - Ringel,Yehuda, AU - Ringel-Kulka,Tamar, PY - 2015/10/9/entrez PY - 2015/10/9/pubmed PY - 2016/7/22/medline SP - S56 EP - 9 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 49 Suppl 1 N2 - Irritable bowel syndrome (IBS) is the most prevalent and the best studied functional gastrointestinal disorder. The etiology and the pathogenesis of IBS are still not clear; however, recent studies have implicated a role for alterations in the intestinal microbiota (dysbiosis) in the pathophysiology of the disorder. Epidemiological observations have demonstrated that the development of IBS symptoms is often preceded by a disruption of the individual's normal intestinal microbiota, and microbiological studies have demonstrated compositional differences in the intestinal microbiota between patients with IBS patients and healthy controls. In addition, animal studies and a few recent human clinical studies have demonstrated that compositional changes in the intestinal microbiota in IBS are associated with relevant abnormal gastrointestinal and brain-gut axis functions that are often observed in patients with IBS. This article discusses points of interest from the current research on the microbiota-gut-brain interactions in IBS and highlights the relevance of the emerging data to our understanding of the disorder and the clinical implications for patients' care. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/26447966/The_Intestinal_Microbiota_and_Irritable_Bowel_Syndrome_ L2 - https://doi.org/10.1097/MCG.0000000000000418 DB - PRIME DP - Unbound Medicine ER -