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Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients.
Scand J Immunol. 2016 Jan; 83(1):58-63.SJ

Abstract

Patients with chronic renal failure are known to have renal osteodystrophy (bone disease) and increased calcification of vessels. A new marker of bone disease, sclerostin, the two pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18), and the fibroblast growth factor-23 (FGF-23) receptor-associated marker Klotho were tested in 84 haemodialysis (HD) patients and in healthy controls. The patients had significantly higher levels of the three former markers than of the controls while Klotho was significantly higher in the controls. Low level, but significant, correlations were observed in the patient group when the levels of these four markers were compared to each other and to those of 5 cytokines and growth factors tested earlier; high-sensitive CRP (hsCRP), interleukin-6 (IL-6), hepatocyte growth factor (HGF), fibroblast growth factor-23 (FGF-23) and soluble urokinase plasminogen activator (suPAR). Ln sclerostin correlated positively to Ln hsTNF-alpha, Ln HGF and Ln suPAR. Ln hsTNF-alpha correlated positively to Ln sclerostin, Ln hsCRP, Ln IL-6, Ln FGF-23, Ln suPAR and Ln IL-18. Ln IL-18 correlated positively to Ln suPAR and Ln TNF-alpha. Ln Klotho correlated negatively to Ln hsCRP but did not correlate to Ln FGF-23. The markers studied here may be involved in the calcification of vessels seen in HD patients due to a combination of inflammation and bone disease. The mechanisms are still not fully known but may be of importance for future therapeutic possibilities in this group of patients.

Authors+Show Affiliations

Department of Nephrology, Institution of medicine and health sciences, Linköping University, Linköping, Sweden.Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden.Department of Nephrology, Institution of medicine and health sciences, Linköping University, Linköping, Sweden.Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden. Department of Physiology, County Hospital, Kalmar, Sweden.Department of Clinical Immunology, Sahlgrenska University Hospital, Göteborg, Sweden.Department of Clinical Immunology, Sahlgrenska University Hospital, Göteborg, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26448366

Citation

Almroth, G, et al. "Sclerostin, TNF-alpha and Interleukin-18 Correlate and Are Together With Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients." Scandinavian Journal of Immunology, vol. 83, no. 1, 2016, pp. 58-63.
Almroth G, Lönn J, Uhlin F, et al. Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scand J Immunol. 2016;83(1):58-63.
Almroth, G., Lönn, J., Uhlin, F., Brudin, L., Andersson, B., & Hahn-Zoric, M. (2016). Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scandinavian Journal of Immunology, 83(1), 58-63. https://doi.org/10.1111/sji.12392
Almroth G, et al. Sclerostin, TNF-alpha and Interleukin-18 Correlate and Are Together With Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scand J Immunol. 2016;83(1):58-63. PubMed PMID: 26448366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. AU - Almroth,G, AU - Lönn,J, AU - Uhlin,F, AU - Brudin,L, AU - Andersson,B, AU - Hahn-Zoric,M, PY - 2015/04/23/received PY - 2015/09/28/accepted PY - 2015/10/9/entrez PY - 2015/10/9/pubmed PY - 2016/5/4/medline SP - 58 EP - 63 JF - Scandinavian journal of immunology JO - Scand J Immunol VL - 83 IS - 1 N2 - Patients with chronic renal failure are known to have renal osteodystrophy (bone disease) and increased calcification of vessels. A new marker of bone disease, sclerostin, the two pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18), and the fibroblast growth factor-23 (FGF-23) receptor-associated marker Klotho were tested in 84 haemodialysis (HD) patients and in healthy controls. The patients had significantly higher levels of the three former markers than of the controls while Klotho was significantly higher in the controls. Low level, but significant, correlations were observed in the patient group when the levels of these four markers were compared to each other and to those of 5 cytokines and growth factors tested earlier; high-sensitive CRP (hsCRP), interleukin-6 (IL-6), hepatocyte growth factor (HGF), fibroblast growth factor-23 (FGF-23) and soluble urokinase plasminogen activator (suPAR). Ln sclerostin correlated positively to Ln hsTNF-alpha, Ln HGF and Ln suPAR. Ln hsTNF-alpha correlated positively to Ln sclerostin, Ln hsCRP, Ln IL-6, Ln FGF-23, Ln suPAR and Ln IL-18. Ln IL-18 correlated positively to Ln suPAR and Ln TNF-alpha. Ln Klotho correlated negatively to Ln hsCRP but did not correlate to Ln FGF-23. The markers studied here may be involved in the calcification of vessels seen in HD patients due to a combination of inflammation and bone disease. The mechanisms are still not fully known but may be of importance for future therapeutic possibilities in this group of patients. SN - 1365-3083 UR - https://www.unboundmedicine.com/medline/citation/26448366/Sclerostin_TNF_alpha_and_Interleukin_18_Correlate_and_are_Together_with_Klotho_Related_to_Other_Growth_Factors_and_Cytokines_in_Haemodialysis_Patients_ L2 - https://doi.org/10.1111/sji.12392 DB - PRIME DP - Unbound Medicine ER -