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Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat.
Neurosci Res. 2016 Apr; 105:65-9.NR

Abstract

The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10μg/1μL; PPARα antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPARα may participate in the sleep and neurochemical modulation.

Authors+Show Affiliations

Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.Departamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, D.F., Mexico.Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General "Dr. Manuel Gea González", México, D.F., Mexico.Coordinación de Investigación, Vicerrectoría Académica, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico; Grupo de Investigación en Envejecimiento, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico; Grupo de Investigación en Desarrollos Tecnológicos para la Salud, División de Ingeniería y Ciencias Exactas, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico; Grupo de Investigación en Envejecimiento, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico; Grupo de Investigación en Desarrollos Tecnológicos para la Salud, División de Ingeniería y Ciencias Exactas, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico. Electronic address: eric.murillo@anahuac.mx.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26450400

Citation

Mijangos-Moreno, Stephanie, et al. "Sleep and Neurochemical Modulation By the Nuclear Peroxisome Proliferator-activated Receptor Α (PPAR-α) in Rat." Neuroscience Research, vol. 105, 2016, pp. 65-9.
Mijangos-Moreno S, Poot-Aké A, Guzmán K, et al. Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat. Neurosci Res. 2016;105:65-9.
Mijangos-Moreno, S., Poot-Aké, A., Guzmán, K., Arankowsky-Sandoval, G., Arias-Carrión, O., Zaldívar-Rae, J., Sarro-Ramírez, A., & Murillo-Rodríguez, E. (2016). Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat. Neuroscience Research, 105, 65-9. https://doi.org/10.1016/j.neures.2015.09.005
Mijangos-Moreno S, et al. Sleep and Neurochemical Modulation By the Nuclear Peroxisome Proliferator-activated Receptor Α (PPAR-α) in Rat. Neurosci Res. 2016;105:65-9. PubMed PMID: 26450400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat. AU - Mijangos-Moreno,Stephanie, AU - Poot-Aké,Alwin, AU - Guzmán,Khalil, AU - Arankowsky-Sandoval,Gloria, AU - Arias-Carrión,Oscar, AU - Zaldívar-Rae,Jaime, AU - Sarro-Ramírez,Andrea, AU - Murillo-Rodríguez,Eric, Y1 - 2015/10/09/ PY - 2015/05/14/received PY - 2015/09/17/revised PY - 2015/09/24/accepted PY - 2015/10/10/entrez PY - 2015/10/10/pubmed PY - 2016/12/31/medline KW - Adenosine KW - Dopamine KW - HPLC KW - Microdialysis KW - Serotonin KW - Waking SP - 65 EP - 9 JF - Neuroscience research JO - Neurosci Res VL - 105 N2 - The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10μg/1μL; PPARα antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPARα may participate in the sleep and neurochemical modulation. SN - 1872-8111 UR - https://www.unboundmedicine.com/medline/citation/26450400/Sleep_and_neurochemical_modulation_by_the_nuclear_peroxisome_proliferator_activated_receptor_α__PPAR_α__in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(15)00229-1 DB - PRIME DP - Unbound Medicine ER -