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Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients.

Abstract

INTRODUCTION

The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma-COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown.

AIM

Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters.

METHODS

A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients.

RESULTS

The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86±1.79 ng/mL and 14.27±1.88 ng/mL vs 25.66±1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group.

CONCLUSION

Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity.

Authors+Show Affiliations

Department of Pulmonology, Semmelweis University, Budapest, Hungary.Department of Pulmonology, Semmelweis University, Budapest, Hungary.Department of Pulmonology, Semmelweis University, Budapest, Hungary.Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.Department of Pulmonology, Semmelweis University, Budapest, Hungary.Department of Pulmonology, Semmelweis University, Budapest, Hungary.Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.Department of Pulmonology, Semmelweis University, Budapest, Hungary.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26451099

Citation

Odler, Balázs, et al. "Vitamin D Deficiency Is Associated With Impaired Disease Control in asthma-COPD Overlap Syndrome Patients." International Journal of Chronic Obstructive Pulmonary Disease, vol. 10, 2015, pp. 2017-25.
Odler B, Ivancsó I, Somogyi V, et al. Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients. Int J Chron Obstruct Pulmon Dis. 2015;10:2017-25.
Odler, B., Ivancsó, I., Somogyi, V., Benke, K., Tamási, L., Gálffy, G., ... Müller, V. (2015). Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients. International Journal of Chronic Obstructive Pulmonary Disease, 10, pp. 2017-25. doi:10.2147/COPD.S91654.
Odler B, et al. Vitamin D Deficiency Is Associated With Impaired Disease Control in asthma-COPD Overlap Syndrome Patients. Int J Chron Obstruct Pulmon Dis. 2015;10:2017-25. PubMed PMID: 26451099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients. AU - Odler,Balázs, AU - Ivancsó,István, AU - Somogyi,Vivien, AU - Benke,Kálmán, AU - Tamási,Lilla, AU - Gálffy,Gabriella, AU - Szalay,Balázs, AU - Müller,Veronika, Y1 - 2015/09/24/ PY - 2015/10/10/entrez PY - 2015/10/10/pubmed PY - 2016/6/18/medline KW - ACOS KW - CAT KW - obstructive lung disease SP - 2017 EP - 25 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 10 N2 - INTRODUCTION: The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma-COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown. AIM: Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters. METHODS: A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients. RESULTS: The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86±1.79 ng/mL and 14.27±1.88 ng/mL vs 25.66±1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group. CONCLUSION: Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/26451099/Vitamin_D_deficiency_is_associated_with_impaired_disease_control_in_asthma_COPD_overlap_syndrome_patients_ L2 - https://dx.doi.org/10.2147/COPD.S91654 DB - PRIME DP - Unbound Medicine ER -